Results 11 to 20 of about 11,616,495 (310)
The role of CPEB family proteins in the nervous system function in the norm and pathology
Cell & Bioscience, 2021 Posttranscriptional gene regulation includes mRNA transport, localization, translation, and regulation of mRNA stability. CPEB (cytoplasmic polyadenylation element binding) family proteins bind to specific sites within the 3′-untranslated region and ...
Eugene Kozlov +4 more
doaj +1 more source
Gene regulation by long non-coding RNAs and its biological functions
Nature reviews. Molecular cell biology, 2020 Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs) are widely expressed and have key roles in gene regulation. Recent studies have begun to unravel how the biogenesis of lncRNAs is distinct from that of mRNAs and is ...
Luisa Statello +3 more
semanticscholar +1 more source
Transcription factors: Bridge between cell signaling and gene regulation
Proteomics, 2021 Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as differentiation and development, and of the cellular response to external perturbation through signaling pathways.
Paula Weidemüller +3 more
semanticscholar +1 more source
Scientific Reports, 2021 Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α regulate metabolic adaptation by modulating many gene programs. Selective ablation of PGC-1α attenuates diet-induced obesity through enhancing fatty acid oxidation and thermogenesis by ...
Jihyun Kim +6 more
doaj +1 more source
Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria
bioRxiv, 2021 Bacteria allocate their proteome to cellular functions differently in different growth conditions. It is largely unknown how such allocation arises from known mechanisms of gene regulation while constrained by limited translation capacity and fixed ...
Rohan Balakrishnan +6 more
semanticscholar +1 more source
Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
Nature Communications, 2020 Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence.
Bo Zhao +11 more
doaj +1 more source
At the dawn: cell-free DNA fragmentomics and gene regulation
British Journal of Cancer, 2021 Epigenetic mechanisms play instrumental roles in gene regulation during embryonic development and disease progression. However, it is challenging to non-invasively monitor the dynamics of epigenomes and related gene regulation at inaccessible human ...
Yaping Liu
semanticscholar +1 more source
Scientific Reports, 2021 A promising therapy for patients with B-cell lymphoma is based on vaccination with idiotype monoclonal antibodies (mAbs). Since idiotypes are different in each tumor, a personalized vaccine has to be produced for each patient.
Erkuden Casales +11 more
doaj +1 more source
Cells, 2021 Components of the translation apparatus, including ribosomal proteins, have been found in cell nuclei in various organisms. Components of the translation apparatus are involved in various nuclear processes, particularly those associated with genome ...
Zaur M. Kachaev +4 more
doaj +1 more source
NF90 interacts with components of RISC and modulates association of Ago2 with mRNA
BMC Biology, 2022 Background Nuclear factor 90 (NF90) is a double-stranded RNA-binding protein involved in a multitude of different cellular mechanisms such as transcription, translation, viral infection, and mRNA stability.
Giuseppa Grasso +6 more
doaj +1 more source