Results 11 to 20 of about 6,256,288 (301)

Stochastic neural network models for gene regulatory networks [PDF]

, 2003
Recent advances in gene-expression profiling technologies provide large amounts of gene expression data. This raises the possibility for a functional understanding of genome dynamics by means of mathematical modelling.
Tian, T., Burrage, K.
core   +9 more sources

Switching and diffusion models for gene regulation networks [PDF]

, 2009
We analyze a hierarchy of three regimes for modeling gene regulation. The most complete model is a continuous time, discrete state space, Markov jump process.
Higham, Desmond J., Mao, X., Intep, Somkid   +2 more
core   +4 more sources

A minimal bile salt excretory pump promoter allows bile acid-driven physiological regulation of transgene expression from a gene therapy vector

Cell & Bioscience, 2022
Background Bile acid (BA) homeostasis is mainly regulated by bile salt excretory pump (BSEP), a hepatocyte transporter that transfers BAs to the bile.
Javier Martínez-García, Manuela Molina, Leticia Odriozola, Angie Molina, Gloria González-Aseguinolaza, Nicholas D. Weber, Cristian Smerdou   +6 more
doaj   +1 more source

Regulation of the Globin Genes [PDF]

Pediatric Research, 2002
The a- and b-globin gene clusters are subject to several levels of regulation. They are expressed exclusively in the erythroid cells, only during defined periods of development and in a perfectly tuned way, assuring, at any stage of ontogeny, a correct balance in the availability of a- and b-globin chains for hemoglobin assembling. Such a tight control
Cao A, MOI, PAOLO
openaire   +3 more sources

CTCF and cohesin promote focal detachment of DNA from the nuclear lamina

Genome Biology, 2022
Background Lamina-associated domains (LADs) are large genomic regions that are positioned at the nuclear lamina. It has remained largely unclear what drives the positioning and demarcation of LADs.
Tom van Schaik, Ning Qing Liu, Stefano G. Manzo, Daan Peric-Hupkes, Elzo de Wit, Bas van Steensel   +5 more
doaj   +1 more source

Gene Regulation and Transcriptomics [PDF]

Current Issues in Molecular Biology, 2021
Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition from a vertebrate host to a tick vector and transmission from a tick vector to a vertebrate host.
Samuels, D. Scott, Lybecker, Meghan C., Yang, X. Frank, Ouyang, Zhiming, Bourret, Travis J., Boyle, William K., Stevenson, Brian, Drecktrah, Dan, Caimano, Melissa J.   +8 more
openaire   +2 more sources

The role of CPEB family proteins in the nervous system function in the norm and pathology

Cell & Bioscience, 2021
Posttranscriptional gene regulation includes mRNA transport, localization, translation, and regulation of mRNA stability. CPEB (cytoplasmic polyadenylation element binding) family proteins bind to specific sites within the 3′-untranslated region and ...
Eugene Kozlov, Yulii V. Shidlovskii, Rudolf Gilmutdinov, Paul Schedl, Mariya Zhukova   +4 more
doaj   +1 more source

NT-PGC-1α deficiency attenuates high-fat diet-induced obesity by modulating food intake, fecal fat excretion and intestinal fat absorption

Scientific Reports, 2021
Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α regulate metabolic adaptation by modulating many gene programs. Selective ablation of PGC-1α attenuates diet-induced obesity through enhancing fatty acid oxidation and thermogenesis by ...
Jihyun Kim, Jiyoung Moon, Chul-Hong Park, Jisu Lee, Helia Cheng, Z. Elizabeth Floyd, Ji Suk Chang   +6 more
doaj   +1 more source

Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence

Nature Communications, 2020
Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence.
Bo Zhao, Pingyu Liu, Takeshi Fukumoto, Timothy Nacarelli, Nail Fatkhutdinov, Shuai Wu, Jianhuang Lin, Katherine M. Aird, Hsin-Yao Tang, Qin Liu, David W. Speicher, Rugang Zhang   +11 more
doaj   +1 more source

Idiotype vaccines produced with a non-cytopathic alphavirus self-amplifying RNA vector induce antitumor responses in a murine model of B-cell lymphoma

Scientific Reports, 2021
A promising therapy for patients with B-cell lymphoma is based on vaccination with idiotype monoclonal antibodies (mAbs). Since idiotypes are different in each tumor, a personalized vaccine has to be produced for each patient.
Erkuden Casales, Eva Martisova, Helena Villanueva, Ascensión López Díaz de Cerio, Susana Inoges, Noelia Silva-Pilipich, María Cristina Ballesteros-Briones, Alejandro Aranda, Jaione Bezunartea, Maurizio Bendandi, Fernando Pastor, Cristian Smerdou   +11 more
doaj   +1 more source