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Live-cell visualisation of chromatin for the study of radiation-induced chromosome aberrations [PDF]
, 2011 This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.Chromosomes can be visualised during the metaphase stage of the cell cycle however, there are various limitations associated with the visualisation of ...
Malis, Georgios
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Fun30 and Rtt109 Mediate Epigenetic Regulation of the DNA Damage Response Pathway in C. albicans
Journal of Fungi, 2022 Fun30, an ATP-dependent chromatin remodeler from S. cerevisiae, is known to mediate both regulation of gene expression as well as DNA damage response/repair. The Fun30 from C. albicans has not yet been elucidated. We show that C.
Prashant Kumar Maurya +10 more
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Current Biology, 2015 Chromatin is a complex of proteins, RNA and DNA that constitutes the physiological state of the genome. Its basic structure is essentially the same in nearly all eukaryotes, from single-celled yeasts to the most complex multicellular organisms (exceptions include the chromatin of dinoflagellates and vertebrate sperm). Its fundamental role is to package
Gross, David S. +3 more
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Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice
Nature Communications, 2021 Misregulation of chromatin has been linked to many conditions, including obesity, but the details remain unclear. Here the authors identify the H4 lysine 16 acetyltransferase MOF as a master regulator of glucose metabolism that is required for normal ...
Cecilia Pessoa Rodrigues +6 more
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Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver
Molecular Systems Biology, 2022 Regulation of gene expression is linked to the organization of the genome. With age, chromatin alterations occur on all levels of genome organization, accompanied by changes in the gene expression profile.
Mihaela Bozukova +5 more
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Chromatin Boundaries and Chromatin Domains [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2004 Insulator elements were first described in Drosophila, but subsequent studies have shown that they are present in vertebrates as well (for review, see West et al. 2002). Over the past several years we have focused our attention on the properties of an insulator at the 5énd of the chicken β-globin locus that has begun to provide an understanding of how ...
Felsenfeld, G. +13 more
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Chromatin Unlimited: An Evolutionary View of Chromatin [PDF]
Epigenomes, 2022 Chromatin is a fundamental and highly conserved structure that carries genetic and epigenetic information in eukaryotic cells [...]
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Chromatin Loop Extrusion and Chromatin Unknotting [PDF]
Polymers, 2018 It has been a puzzle how decondensed interphase chromosomes remain essentially unknotted. The natural expectation is that in the presence of type II DNA topoisomerases that permit passages of double-stranded DNA regions through each other, all chromosomes should reach the state of topological equilibrium.
Racko, Dusan +3 more
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Histochemistry and Cell Biology, 2018 The nucleolus as site of ribosome biogenesis holds a pivotal role in cell metabolism. It is composed of ribosomal DNA (rDNA), which is present as tandem arrays located in nucleolus organizer regions (NORs). In interphase cells, rDNA can be found inside and adjacent to nucleoli and the location is indicative for transcriptional activity of ribosomal ...
Christian Schöfer, Klara Weipoltshammer
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Epigenetics & Chromatin, 2021 Background H1T2/H1FNT is a germ cell-specific linker histone variant expressed during spermiogenesis specifically in round and elongating spermatids. Infertile phenotype of homozygous H1T2 mutant male mice revealed the essential function of H1T2 for the ...
Vasantha Shalini +4 more
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