Results 11 to 20 of about 621,772 (309)
Epigenetic signals that direct cell type–specific interferon beta response in mouse cells
Life Science Alliance, 2023 Preexisting cell type–specific chromatin features represent an additional regulatory layer for interferon beta response and direct binding of STAT transcription factors and gene induction. The antiviral response induced by type I interferon (IFN) via the
Markus Muckenhuber +9 more
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Frontiers in Cell and Developmental Biology, 2023 In vitro cell line model systems are essential in supporting the research community due to their low cost, uniform culturing conditions, homogeneous biological resources, and easy experimental design to study the cause and effect of a gene or a molecule.
Jhinuk Basu +14 more
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Biotechnology & Biotechnological Equipment, 2021 In the recent years, the application of new antitumor drugs has focused on the replacement of conventional chemotherapeutics with compounds derived from natural products.
Jordana Todorova +4 more
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TelNet - a database for human and yeast genes involved in telomere maintenance
BMC Genetics, 2018 Background The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences in complex with proteins that protects them from being processed by the DNA repair machinery.
Delia M. Braun +4 more
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Nature Communications, 2023 Rhodamines are privileged fluorescent dyes for labelling intracellular structures in living cells. Here, the authors present a facile protecting-group-free synthesis permitting generation of a wide range of symmetrical and unsymmetrical 4 ...
Jonas Bucevičius +6 more
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Regulation of the SUV39H Family Methyltransferases: Insights from Fission Yeast
Biomolecules, 2023 Histones, which make up nucleosomes, undergo various post-translational modifications, such as acetylation, methylation, phosphorylation, and ubiquitylation. In particular, histone methylation serves different cellular functions depending on the location
Rinko Nakamura, Jun-ichi Nakayama
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Proteomic interrogation of human chromatin. [PDF]
, 2011 Chromatin proteins provide a scaffold for DNA packaging and a basis for epigenetic regulation and genomic maintenance. Despite understanding its functional roles, mapping the chromatin proteome (i.e. the "Chromatome") is still a continuing process. Here,
LeRoy, Gary +22 more
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Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]
, 2005 The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Eberharter, Anton +2 more
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ADP-ribosylation: An emerging regulator of the epigenome. [PDF]
Mol OncolADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Camacho CV, Liu C, Kraus WL.
europepmc +2 more sources
Biophysical Journal, 2014 Following recent observations of large scale correlated motion of chromatin inside the nuclei of live differentiated cells, we present a hydrodynamic theory-the two-fluid model-in which the content of a nucleus is described as a chromatin solution with the nucleoplasm playing the role of the solvent and the chromatin fiber that of a solute. This system
Bruinsma, Robijn +3 more
openaire +4 more sources