Results 11 to 20 of about 574,116 (318)
Current Biology, 2015 Chromatin is a complex of proteins, RNA and DNA that constitutes the physiological state of the genome. Its basic structure is essentially the same in nearly all eukaryotes, from single-celled yeasts to the most complex multicellular organisms (exceptions include the chromatin of dinoflagellates and vertebrate sperm). Its fundamental role is to package
Gross, David S. +3 more
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Chromatin Unlimited: An Evolutionary View of Chromatin [PDF]
Epigenomes, 2022 Chromatin is a fundamental and highly conserved structure that carries genetic and epigenetic information in eukaryotic cells [...]
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Chromatin Boundaries and Chromatin Domains [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2004 Insulator elements were first described in Drosophila, but subsequent studies have shown that they are present in vertebrates as well (for review, see West et al. 2002). Over the past several years we have focused our attention on the properties of an insulator at the 5énd of the chicken β-globin locus that has begun to provide an understanding of how ...
Felsenfeld, G. +13 more
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Chromatin Loop Extrusion and Chromatin Unknotting [PDF]
Polymers, 2018 It has been a puzzle how decondensed interphase chromosomes remain essentially unknotted. The natural expectation is that in the presence of type II DNA topoisomerases that permit passages of double-stranded DNA regions through each other, all chromosomes should reach the state of topological equilibrium.
Racko, Dusan +3 more
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WormBook, 2006 The DNA in eukaryotes is wrapped around a histone octamer core, together comprising the main subunit of chromatin, the nucleosome. Modifications of the nucleosomal histones in the genome correlate with the ability or inability of chromatin to form higher order structures, that in turn influence gene activity.
Christine E, Schaner, William G, Kelly
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Proteomic interrogation of human chromatin. [PDF]
, 2011 Chromatin proteins provide a scaffold for DNA packaging and a basis for epigenetic regulation and genomic maintenance. Despite understanding its functional roles, mapping the chromatin proteome (i.e. the "Chromatome") is still a continuing process. Here,
LeRoy, Gary +22 more
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Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]
, 2005 The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Eberharter, Anton +2 more
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Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1
Nature Communications, 2022 The mechanism by which RNAPII transcribes the DNA in the chromatosome with H1 has remained enigmatic. Here the authors present the cryo-EM structures of the RNAPII-chromatosome complexes, and explain how RNAPII is regulated by H1 in chromatin.
Rina Hirano +6 more
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Targeting the Nucleosome Acidic Patch by Viral Proteins: Two Birds with One Stone?
mBio, 2022 The past decade illuminated the H2A-H2B acidic patch as a cornerstone for both nucleosome recognition and chromatin structure regulation. Higher-order folding of chromatin arrays is mediated by interactions of histone H4 tail with an adjacent nucleosome ...
Floriane Lagadec +2 more
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The Adenomatous Polyposis Coli protein contributes to normal compaction of mitotic chromatin [PDF]
, 2012 The tumour suppressor <i>Adenomatous Polyposis Coli</i> (APC) is required for proper mitosis; however, the exact role of APC in mitosis is not understood.
Newton, Ian P. +44 more
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