Results 41 to 50 of about 636,375 (263)

Studies toward in vitro reconstitution of plant chromatin [PDF]

, 2009
To study the relation between chromatin structure and DNA function in detail it is necessary to have an in vitro procedure for assembling nucleosomes on a naked DNA template with properties similar to native chromatin.
NC DOCKS at Western Carolina University, Martinez, Nicholas   +1 more
core  

Unconventional metabolites in chromatin regulation

, 2021
Chromatin, the complex of DNA and histone proteins, serves as a main integrator of cellular signals. Increasing evidence links cellular functional to chromatin state.
Alfardus, Huda, Fischle, Wolfgang, Gapa, Liubov   +2 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Structural basis of nucleosome remodeling by Cockayne syndrome B homologue Komagataella phaffii Rad26

Nature Communications
Rad26, a yeast homologue of mammalian Cockayne syndrome protein B (CSB), plays an essential role in transcription-coupled nucleotide excision repair (TC-NER).
Yutaro Fukushima, Chiaki Kinoshita, Lumi Negishi, Tomoya Kujirai, Yuki Kobayashi, Mitsuo Ogasawara, Haruhiko Ehara, Shun-ichi Sekine, Wataru Kagawa, Hitoshi Kurumizaka, Yoshimasa Takizawa   +10 more
doaj   +1 more source

Chromatin Alterations in Neurological Disorders and Strategies of (Epi)Genome Rescue

Pharmaceuticals, 2021
Neurological disorders (NDs) comprise a heterogeneous group of conditions that affect the function of the nervous system. Often incurable, NDs have profound and detrimental consequences on the affected individuals’ lives.
Marcin Janowski, Małgorzata Milewska, Peyman Zare, Aleksandra Pękowska   +3 more
doaj   +1 more source

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation [PDF]

, 2010
Background: Brahma-related gene 1 (Brg1, also known as Smarca4 and Snf2 beta) encodes an adenosine-5'-triphosphate (ATP)-dependent catalytical subunit of the (switch/sucrose nonfermentable) (SWI/SNF) chromatin remodeling complexes.
He, Shuying, Metzger, Daniel, Wolf Louise, Bharesh K Chauhan, Chambon, Pierre, Ruth Ashery-Padan, Nakai, Akira, Zavadil, Jiri, Cveklova Kveta, Daniel Metzger, Ernst R Tamm, Chauhan Bharesh K, Metzger Daniel, Melinda K Pirity, Wang Wei-Lin, Chauhan, Bharesh K., Pierre Chambon, Cveklova, Kveta, Cvekl Ales, Akira Nakai, Ales Cvekl, Pirity Melinda K, Wolf, Louise, Tamm, Ernst R., Ashery-Padan, Ruth, Cvekl, Ales, Chambon Pierre, Wang, Wei-Lin, Wei-Lin Wang, Ashery-Padan Ruth, Nakai Akira, He Shuying, Shuying He, Kveta Cveklova, Zavadil Jiri, Louise Wolf, Tamm Ernst R, Jiri Zavadil, Pirity, Melinda K.   +38 more
core   +1 more source

Untangling chromatin interactions [PDF]

, 2020
International audienceUntangling chromatin interactions The plant nucleus contains myriad subdomains that define and are defined by the composition of their chromatin.
Probst, Aline V., Probst, Aline,, Pradillo Orellana, Mónica, Parry, Geraint, Pradillo, Mónica, Tatout, Christophe, Probst, Aline V, Probst, Aline, V.   +7 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

SUV family histone methyltransferases correlate with nuclear lamina remodeling and clinical outcome in cancer: integrative pan-cancer TCGA analysis and experimental evidence

Scientific Reports
Epigenetic regulation of chromatin structure is a key determinant of transcriptional control and nuclear organization in cancer. Among histone lysine methyltransferases, SUV39H1 and SUV39H2 catalyze the trimethylation of histone H3 lysine 9 (H3K9me3 ...
Subhadip Kundu, Abdur Rahmaan Akhtar, Arun Kumar, Ashok Sharma   +3 more
doaj   +1 more source

Internal modifications in the CENP-A nucleosome modulate centromeric dynamics

Epigenetics & Chromatin, 2017
Background Posttranslational modifications of core histones are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within the centromere-specific histone H3 variant CENP-A, few modifications have
Minh Bui, Mary Pitman, Arthur Nuccio, Serene Roque, Paul Gregory Donlin-Asp, Aleksandra Nita-Lazar, Garegin A. Papoian, Yamini Dalal   +7 more
doaj   +1 more source