Results 21 to 30 of about 788,103 (308)
Bio-Protocol, 2021 β-hemoglobinopathies are severe genetic disorders characterized either by the abnormal synthesis of the adult β-globin chains of the hemoglobin (Hb) tetramer (βS-globin chains) in sickle cell disease (SCD) or by the reduced β-globin production in β ...
Anne Chalumeau +3 more
doaj +1 more source
Biophysical Journal, 2014 Following recent observations of large scale correlated motion of chromatin inside the nuclei of live differentiated cells, we present a hydrodynamic theory-the two-fluid model-in which the content of a nucleus is described as a chromatin solution with the nucleoplasm playing the role of the solvent and the chromatin fiber that of a solute. This system
Bruinsma, Robijn +3 more
openaire +4 more sources
Determinants of a transcriptionally competent environment at the GM-CSF promoter [PDF]
, 2015 Granulocyte macrophage-colony stimulating factor (GM-CSF) is produced by T cells, but not B cells, in response to immune signals. GM-CSF gene activation in response to T-cell stimulation requires remodelling of chromatin associated with the gene ...
Brettingham-Moore, Kate H +5 more
core +1 more source
Epigenetics & Chromatin, 2018 Background Linker histones establish and maintain higher-order chromatin structure. Eleven linker histone subtypes have been reported in mammals. HILS1 is a spermatid-specific linker histone, and its expression overlaps with the histone–protamine ...
Laxmi Narayan Mishra +6 more
doaj +1 more source
Defining the chromatin signature of inducible genes in T cells [PDF]
, 2016 BACKGROUND Specific chromatin characteristics, especially the modification status of the core histone proteins, are associated with active and inactive genes. There is growing evidence that genes that respond to environmental or developmental signals may
Bunting, Karen +6 more
core +1 more source
Influence of M-phase chromatin on the anisotropy of microtubule asters [PDF]
, 1996 In many eukaryotic cells going through M-phase, a bipolar spindle is formed by microtubules nucleated from centrosomes. These microtubules, in addition to being "captured" by kinetochores, may be stabilized by chromatin in two different ways: short-range
Dogterom, M. +3 more
core +2 more sources
Stem Cells International, 2021 Transposable elements (TEs) are mobile genetic sequences capable of duplicating and reintegrating at new regions within the genome. A growing body of evidence has demonstrated that these elements play important roles in host genome evolution, despite ...
Yixuan Low +4 more
doaj +1 more source
Microbial Cell, 2023 Enhanced levels of acetic acid reduce the activity of yeast strains employed for industrial fermentation-based applications. Therefore, unraveling the genetic factors underlying the regulation of the tolerance and sensitivity of yeast towards acetic acid
Nitu Saha +2 more
doaj +1 more source
Cytoplasmic chromatin triggers inflammation in senescence and cancer [PDF]
, 2017 Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a ...
Adams, Peter D. +23 more
core +2 more sources
Quantifying nuclear wide chromatin compaction by phasor analysis of histone Förster resonance energy transfer (FRET) in frequency domain fluorescence lifetime imaging microscopy (FLIM) data. [PDF]
, 2020 The nanometer spacing between nucleosomes throughout global chromatin organisation modulates local DNA template access, and through continuous dynamic rearrangements, regulates genome function [1].
Gratton, Enrico +4 more
core +3 more sources