Results 1 to 10 of about 129,047 (304)

Structure and function of archaeal histones [PDF]

PLoS Genetics, 2018
The genomes of all organisms throughout the tree of life are compacted and organized in chromatin by association of chromatin proteins. Eukaryotic genomes encode histones, which are assembled on the genome into octamers, yielding nucleosomes.
Bram Henneman, Clara L Van Emmerik, Hugo Van Ingen   +2 more
exaly   +4 more sources

LPS-Challenged Macrophages Release Microvesicles Coated With Histones

Frontiers in Immunology, 2018
Histones are the protein component of nucleosomes, which are the basic packing unit of chromatin. However, histones are also found in the blood, both as components of nucleosomes leaked out from dead cells, or expelled from neutrophils in the active ...
Rohini R Nair, Davide Mazza, Francesca Brambilla   +2 more
exaly   +4 more sources

Rapid purification of recombinant histones. [PDF]

PLoS ONE, 2014
The development of methods to assemble nucleosomes from recombinant histones decades ago has transformed chromatin research. Nevertheless, nucleosome reconstitution remains time consuming to this day, not least because the four individual histones must ...
Henrike Klinker, Caroline Haas, Nadine Harrer, Peter B Becker, Felix Mueller-Planitz   +4 more
doaj   +3 more sources

Structural analysis of OCT4 binding to human LIN28B nucleosomes [PDF]

Scientific Reports
Structural studies of nucleosomes most commonly involve histones from Xenopus species or humans. Yet, the effect of subtle differences in the amino acid sequences of these histones on key aspects of structure, such as nucleosome assembly, DNA positioning,
Kalyan K. Sinha, Mario Halic
doaj   +2 more sources

Modification of histones by the myeloperoxidase-derived oxidant hypochlorous acid (HOCl) alters their reactivity with vascular smooth muscle cells

Redox Biochemistry and Chemistry, 2023
In the nucleus, histones are essential in the packaging of DNA and the regulation of gene expression. These histones can also be released to the extracellular space by mechanisms such as necrosis and neutrophil extracellular trap (NET) formation ...
Els A. Hartsema, Line A.E. Hallberg, Kristine Barlous, Clare L. Hawkins   +3 more
doaj   +1 more source

In vitro interactions of extracellular histones with LDL suggest a potential pro-atherogenic role. [PDF]

PLoS ONE, 2010
Nuclear histones have previously been shown to aggregate LDL in vitro, suggestive of a possible pro-atherogenic role. Recent studies indicate that histones are released during acute inflammation, and therefore might interact with circulating lipoproteins
Alan D Pemberton, Jeremy K Brown
doaj   +1 more source

Multiple Sclerosis: Enzymatic Cross Site-Specific Recognition and Hydrolysis of H3 Histone by IgGs against H3, H1, H2A, H2B, H4 Histones, Myelin Basic Protein, and DNA

Biomedicines, 2022
Histones have a specific key role in the remodeling of chromatin and gene transcription. In the blood, free histones are damage-connected proteins. Myelin basic protein (MBP) is the major component of the myelin-proteolipid sheath of axons.
Georgy A. Nevinsky, Valentina N. Buneva, Pavel S. Dmitrenok   +2 more
doaj   +1 more source

Actin and DNA protect histones from degradation by bacterial proteases but inhibit their antimicrobial activity

Frontiers in Microbiology, 2016
Histones are small polycationic proteins located in the cell nucleus. Together, DNA and histones are integral constituents of the nucleosomes. Upon apoptosis, necrosis and infection - induced cell death, histones are released from the cell.
Asaf Sol, Yaniv Skivrsky, Edna Blotnick, Gilad Bachrach, Andras Muhlrad   +4 more
doaj   +1 more source

Structural Analysis of SMYD3 Lysine Methyltransferase for the Development of Competitive and Specific Enzyme Inhibitors

Diseases, 2021
Lysine methylation is among the key posttranslational modifications to histones that contribute to epigenetic regulation. SMYD3 is a lysine methyltransferase that is essential for the proliferation of a range of tumorigenic cells. The findings that SMYD3
Dillon K. Jarrell, Kelly N. Hassell, Ilham Alshiraihi, Debbie C. Crans, Mark A. Brown   +4 more
doaj   +1 more source

DNA and factor VII–activating protease protect against the cytotoxicity of histones

Blood Advances, 2017
: Circulating histones have been implicated as major mediators of inflammatory disease because of their strong cytotoxic effects. Histones form the protein core of nucleosomes; however, it is unclear whether histones and nucleosomes are equally cytotoxic.
Gerben Marsman, Helen von Richthofen, Ingrid Bulder, Florea Lupu, Jan Hazelzet, Brenda M. Luken, Sacha Zeerleder   +6 more
doaj   +1 more source