Results 41 to 50 of about 183,055 (305)

Phasor Histone FLIM-FRET Microscopy Maps Nuclear-Wide Nanoscale Chromatin Architecture With Respect to Genetically Induced DNA Double-Strand Breaks

Frontiers in Genetics, 2021
A DNA double-strand break (DSB) takes place in the context of chromatin, and there is increasing evidence for chromatin structure to play a functional role in DSB signaling and repair.
Jieqiong Lou, Jieqiong Lou, Ashleigh Solano, Ashleigh Solano, Zhen Liang, Zhen Liang, Elizabeth Hinde, Elizabeth Hinde   +7 more
doaj   +1 more source

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones [PDF]

, 2013
Neutrophil extracellular traps are networks of DNA and associated proteins produced by nucleosome release from activated neutrophils in response to infection stimuli and have recently been identified as key mediators between innate immunity, inflammation,
Ammollo, Aziz, Borissoff, Brill, Brinkmann, Clark, Esmon, Esmon, Fuchs, Fuchs, Gladysheva, Gleber, Guthold, Komissarov, Komorowicz, Longstaff, Longstaff, Massberg, Nikolova, Rocha, Ruf, Ryan, Rábai, Rácz, Saha, Sands, Scrutton, Semeraro, Silva, Smeeth, Walker, Weisel, Weisel, Wohner, Xu, Yang, Yeromonahos   +36 more
core   +1 more source

Circulating Nucleosomes and Histones in the Development of Lung Injury and Sepsis

Current Issues in Molecular Biology
Cellular nucleosomes—the structural and functional units of chromatin—are inherently present in cells. During cellular damage or cell death, nucleosomes are released into circulation, either actively or passively.
Saugata Dutta, Sauradeep Dutta, Payaningal R. Somanath, S. Priya Narayanan, Xiaoyun Wang, Duo Zhang   +5 more
doaj   +1 more source

Proteomic Analysis of Serum Lysine Acetylation in Uyghur Patients With T2DM

Frontiers in Molecular Biosciences, 2022
Lysine acetylation is a reversible modification process after protein translation, which plays a key regulatory role in various metabolic diseases such as diabetes.
Liang Yin, Gang Feng, Chun Huang, Weijuan Cai   +3 more
doaj   +1 more source

Enhancement of homology-directed repair with chromatin donor templates in cells. [PDF]

, 2020
A key challenge in precise genome editing is the low efficiency of homology-directed repair (HDR). Here we describe a strategy for increasing the efficiency of HDR in cells by using a chromatin donor template instead of a naked DNA donor template.
Cruz-Becerra, Grisel, Kadonaga, James T
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Redistribution of Histone Marks on Inflammatory Genes Associated With Intracerebral Hemorrhage-Induced Acute Brain Injury in Aging Rats

Frontiers in Neuroscience, 2022
The contribution of histone mark redistribution to the age-induced decline of endogenous neuroprotection remains unclear. In this study, we used an intracerebral hemorrhage (ICH)-induced acute brain injury rat model to study the transcriptional and ...
Qin Zhang, Wei-lin Kong, Jun-Jie Yuan, Qiong Chen, Chang-Xiong Gong, Liang Liu, Fa-Xiang Wang, Jia-Cheng Huang, Guo-Qiang Yang, Kai Zhou, Rui Xu, Xiao-Yi Xiong, Xiao-Yi Xiong, Xiao-Yi Xiong, Qing-Wu Yang   +14 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Bactericidal activity of mammalian histones is caused by large membrane pore formation

Cell Reports
Summary: Histones have an important role in eukaryotic innate immunity, wherein histones co-localize with antimicrobial peptides (AMPs). The mechanism of histone cooperation with AMPs and the extent to which histones form pores both remain a mystery ...
Leora Duong, Yonghan Wu, Summer J. Kasallis, Serena Abbondante, Paul J. Hurst, Michaela E. Marshall, Katherine McCarthy, Babu J.N. Reddy, Jean-Louis Bru, Kumar Perinbam, Eric Pearlman, Joseph P. Patterson, Steven P. Gross, Albert Siryaporn   +13 more
doaj   +1 more source

LSD1 demethylates histone and non-histone proteins [PDF]

Epigenetics, 2009
One of the key breakthroughs in the epigenetics/chromatin field in the last several years was the identification of enzymes capable of removing the methyl group from methylated lysines in histone proteins. Lysine-specific demethylase 1 (LSD1) was the first such enzyme identified, which has been shown to demethylate histone H3 on lysine 4 (H3K4) and ...
Thomas B, Nicholson, Taiping, Chen
openaire   +2 more sources