Results 41 to 50 of about 129,047 (304)
Biological applications of chemically modified recombinant histones
, 2022 In eukaryotes, DNA is packaged into repeating units called nucleosomes, which consist of ~150 base pairs of DNA wrapped around eight proteins called histones.
Josephson, Brian
core +1 more source
Circulating Nucleosomes and Histones in the Development of Lung Injury and Sepsis
Current Issues in Molecular BiologyCellular nucleosomes—the structural and functional units of chromatin—are inherently present in cells. During cellular damage or cell death, nucleosomes are released into circulation, either actively or passively.
Saugata Dutta +5 more
doaj +1 more source
Proteomic Analysis of Serum Lysine Acetylation in Uyghur Patients With T2DM
Frontiers in Molecular Biosciences, 2022 Lysine acetylation is a reversible modification process after protein translation, which plays a key regulatory role in various metabolic diseases such as diabetes.
Liang Yin +3 more
doaj +1 more source
Histones and histone modifications in protozoan parasites
Cellular Microbiology, 2006 Protozoan parasites are early branching eukaryotes causing significant morbidity and mortality in humans and livestock. Single-celled parasites have evolved complex life cycles, which may involve multiple host organisms, and strategies to evade host immune responses.
William J, Sullivan +2 more
openaire +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Frontiers in Neuroscience, 2022 The contribution of histone mark redistribution to the age-induced decline of endogenous neuroprotection remains unclear. In this study, we used an intracerebral hemorrhage (ICH)-induced acute brain injury rat model to study the transcriptional and ...
Qin Zhang +14 more
doaj +1 more source
Nucleic Acids Research, 2002 Histone proteins are often noted for their high degree of sequence conservation. It is less often recognized that the histones are a heterogeneous protein family. Furthermore, several classes of non-histone proteins containing the histone fold motif exist.
Steven A. Sullivan +6 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2012 Core histones play a critical role in the regulation of chromatin-templated biological process. Here we have developed a novel approach to enrich histone proteins based on the recognition of a specific aptamer.
He, Xiwen +5 more
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, 2020 Histones are typically located within the intracellular compartment, and more specifically, within the nucleus. When histones are located within the extracellular compartment, they change roles and become damage-associated molecular patterns (DAMPs ...
Wong, Keith H. K. +7 more
core +1 more source