Results 51 to 60 of about 136,607 (295)

Proteomic Analysis of Serum Lysine Acetylation in Uyghur Patients With T2DM

Frontiers in Molecular Biosciences, 2022
Lysine acetylation is a reversible modification process after protein translation, which plays a key regulatory role in various metabolic diseases such as diabetes.
Liang Yin, Gang Feng, Chun Huang, Weijuan Cai   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Redistribution of Histone Marks on Inflammatory Genes Associated With Intracerebral Hemorrhage-Induced Acute Brain Injury in Aging Rats

Frontiers in Neuroscience, 2022
The contribution of histone mark redistribution to the age-induced decline of endogenous neuroprotection remains unclear. In this study, we used an intracerebral hemorrhage (ICH)-induced acute brain injury rat model to study the transcriptional and ...
Qin Zhang, Wei-lin Kong, Jun-Jie Yuan, Qiong Chen, Chang-Xiong Gong, Liang Liu, Fa-Xiang Wang, Jia-Cheng Huang, Guo-Qiang Yang, Kai Zhou, Rui Xu, Xiao-Yi Xiong, Xiao-Yi Xiong, Xiao-Yi Xiong, Qing-Wu Yang   +14 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Preparation and characterization of DNA aptamer based spin column for enrichment and separation of histones

, 2012
Core histones play a critical role in the regulation of chromatin-templated biological process. Here we have developed a novel approach to enrich histone proteins based on the recognition of a specific aptamer.
He, Xiwen, Chen, Ying, 何锡文, Shao, Nan, Zhang, Yukui, Zhang, Kai   +5 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Bactericidal activity of mammalian histones is caused by large membrane pore formation

Cell Reports
Summary: Histones have an important role in eukaryotic innate immunity, wherein histones co-localize with antimicrobial peptides (AMPs). The mechanism of histone cooperation with AMPs and the extent to which histones form pores both remain a mystery ...
Leora Duong, Yonghan Wu, Summer J. Kasallis, Serena Abbondante, Paul J. Hurst, Michaela E. Marshall, Katherine McCarthy, Babu J.N. Reddy, Jean-Louis Bru, Kumar Perinbam, Eric Pearlman, Joseph P. Patterson, Steven P. Gross, Albert Siryaporn   +13 more
doaj   +1 more source

Distinctive Nuclear Features of Dinoflagellates with A Particular Focus on Histone and Histone-Replacement Proteins

Microorganisms, 2018
Dinoflagellates are important eukaryotic microorganisms that play critical roles as producers and grazers, and cause harmful algal blooms. The unusual nuclei of dinoflagellates “dinokaryon„ have led researchers to investigate their enigmatic ...
Sadaf Riaz, Zhenghong Sui, Zeeshan Niaz, Sohrab Khan, Yuan Liu, Haoxin Liu   +5 more
doaj   +1 more source

Multiple Sclerosis: Enzymatic Cross Site-Specific Recognition and Hydrolysis of H3 Histone by IgGs against H3, H1, H2A, H2B, H4 Histones, Myelin Basic Protein, and DNA

Biomedicines, 2022
Histones have a specific key role in the remodeling of chromatin and gene transcription. In the blood, free histones are damage-connected proteins. Myelin basic protein (MBP) is the major component of the myelin-proteolipid sheath of axons.
Georgy A. Nevinsky, Valentina N. Buneva, Pavel S. Dmitrenok   +2 more
doaj   +1 more source