Results 71 to 80 of about 138,386 (301)

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Structural analysis of OCT4 binding to human LIN28B nucleosomes

Scientific Reports
Structural studies of nucleosomes most commonly involve histones from Xenopus species or humans. Yet, the effect of subtle differences in the amino acid sequences of these histones on key aspects of structure, such as nucleosome assembly, DNA positioning,
Kalyan K. Sinha, Mario Halic
doaj   +1 more source

Hansemann’s anaplastic theory of cancer after 135 years

Frontiers in Epigenetics and Epigenomics
Summary: The term “anaplasia” was coined in 1890 to describe chromosomal changes common to primordial cancer cells, but ever since the mechanisms whereby a cell becomes anaplastic has been the subject of much speculation.
Steven Henikoff, Steven Henikoff, Kami Ahmad   +2 more
doaj   +1 more source

Transcriptional and Post-Transcriptional Regulation and Transcriptional Memory of Chromatin Regulators in Response to Low Temperature

Frontiers in Plant Science, 2020
Chromatin regulation ensures stable repression of stress-inducible genes under non-stress conditions and transcriptional activation and memory of stress-related genes after stress exposure.
Kora Vyse, Léa Faivre, Melissa Romich, Majken Pagter, Daniel Schubert, Dirk K. Hincha, Ellen Zuther   +6 more
doaj   +1 more source

A modified fractionation procedure for avian erythrocyte histones

, 1969
The fractionation method of Vidali and Neelin for avian erythrocyte histones was modified to reduce the time required to obtain clean fractions of serine-rich and arginine-rich histones.
Adams, G.H.M., Neelin, J.M., G. H. M. Adams, J. M. Neelin   +3 more
core   +1 more source

Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria. [PDF]

, 2020
Microvascular thrombosis and blood-brain barrier (BBB) breakdown are key components of cerebral malaria (CM) pathogenesis in African children and are implicated in fatal brain swelling.
Toh, Cheng Hock, Taylor, Terrie E., Molyneux, Malcolm, Sam Kampondeni (114917), Moxon, Christopher A, Abrams, Simon T, Craig, Alister G, Abrams, Simon T., Taylor, Terrie E, James O'Donnell (7895615), Ko, Joo Yeon, García-Cardeña, Guillermo, Potchen, Michael, Kampondeni, Sam, Karl B Seydel (10940154), Toh, Cheng-Hock, Cheng-Hock Toh (739342), O'Donnell, James S., Niamh O'Regan (698186), Moxon, Christopher A., Toh, Cheng, McGuinness, Dagmara, Lane, Steven, Craig, Alister, O’Donnell, James S, Toh, Julien M.H., Seydel, Karl B., Yasir Alhamdi (611011), Wang, Guozheng, Storm, Janet, Simon T Abrams (10940165), Alhamdi, Yasir, O'Donnell, James S, Murphy, George, Alhamadi, Yasir, Alister G Craig (10940163), Julien M H Toh (10940148), Guozheng Wang (611014), Janet Storm (37473), George Murphy (214866), O’Regan, Niamh, Dagmara McGuinness (430856), Seydel, Karl B, Michael Potchen (3500972), Malcolm Molyneux (1711), O'Regan, Niamh, Steven Lane (347900), Joo Yeon Ko (10940151), Toh, Julien MH, Guillermo García-Cardenã (10940162), Terrie E Taylor (10940153), García- Cardeña, Guillermo, Christopher A Moxon (10940147)   +52 more
core   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Artificial intelligence meets epigenetics: a new frontier in precision oncology

Epigenetics Reports
Epigenetics involves heritable and stable changes in gene expression that occur without altering the DNA sequence, primarily through chemical modifications to DNA and alterations in chromatin structure.
Ruby Srivastava
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source