Results 71 to 80 of about 183,055 (305)

Determinants of a transcriptionally competent environment at the GM-CSF promoter [PDF]

, 2015
Granulocyte macrophage-colony stimulating factor (GM-CSF) is produced by T cells, but not B cells, in response to immune signals. GM-CSF gene activation in response to T-cell stimulation requires remodelling of chromatin associated with the gene ...
Brettingham-Moore, Kate H, Chen, Xinxin, Holloway, Adele F, Oakford, P, Shannon, M Frances, Sprod, O R   +5 more
core   +1 more source

Extracellular Histones as Exosome Membrane Proteins Regulated by Cell Stress

Journal of Extracellular Vesicles
Histones are conserved nuclear proteins that function as part of the nucleosome in the regulation of chromatin structure and gene expression. Interestingly, extracellular histones populate biofluids from healthy individuals, and when elevated, may ...
Birendra Singh, Marcus Fredriksson Sundbom, Uma Muthukrishnan, Balasubramanian Natarajan, Stephanie Stransky, André Görgens, Joel Z. Nordin, Oscar P. B. Wiklander, Linda Sandblad, Simone Sidoli, Samir El Andaloussi, Michael Haney, Jonathan D. Gilthorpe   +12 more
doaj   +1 more source

N-acetyl-heparin attenuates acute lung injury caused by acid aspiration mainly by antagonizing histones in mice. [PDF]

PLoS ONE, 2014
Acute lung injury (ALI) is the leading cause of death in intensive care units. Extracellular histones have recently been recognized to be pivotal inflammatory mediators. Heparin and its derivatives can bind histones through electrostatic interaction. The
Yanlin Zhang, Zanmei Zhao, Li Guan, Lijun Mao, Shuqiang Li, Xiaoxu Guan, Ming Chen, Lixia Guo, Lihua Ding, Cuicui Cong, Tao Wen, Jinyuan Zhao   +11 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The Role of Chromatin in Adenoviral Vector Function

Viruses, 2013
Vectors based on adenovirus (Ad) are one of the most commonly utilized platforms for gene delivery to cells in molecular biology studies and in gene therapy applications.
Carmen M. Wong, Emily R. McFall, Joseph K. Burns, Robin J. Parks   +3 more
doaj   +1 more source

Gastropod-derived haemocyte extracellular traps entrap metastrongyloid larval stages of Angiostrongylus vasorum, Aelurostrongylus abstrusus and Troglostrongylus brevior [PDF]

, 2017
Background: Phagocyte-derived extracellular traps (ETs) were recently demonstrated mainly in vertebrate hosts as an important effector mechanism against invading parasites.
Gärtner, Ulrich, Hermosilla, Carlos, Lange, Malin K., Mejer, Helena, Muñoz-Caro, Tamara, Penagos-Tabares, Felipe, Schaper, Roland, Taubert, Anja   +7 more
core   +4 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Retinol-induced changes in the phosphorylation levels of histones and high mobility group proteins from Sertoli cells

Brazilian Journal of Medical and Biological Research, 2000
Chromatin proteins play a role in the organization and functions of DNA. Covalent modifications of nuclear proteins modulate their interactions with DNA sequences and are probably one of the multiple factors involved in the process of switch on/off ...
J.C.F. Moreira, F. Dal-Pizzol, A.B. Rocha, F. Klamt, N.C. Ribeiro, C.J.S. Ferreira, E.A. Bernard   +6 more
doaj   +1 more source

The size of the nucleosome [PDF]

, 2011
The structural origin of the size of the 11 nm nucleosomal disc is addressed. On the nanometer length-scale the organization of DNA as chromatin in the chromosomes involves a coiling of DNA around the histone core of the nucleosome.
A. Travers, Jakob Bohr, Kasper Olsen, S. M. West   +3 more
core   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source