Results 81 to 90 of about 136,607 (295)

Ageing-Related Changes to H3K4me3, H3K27ac, and H3K27me3 in Purified Mouse Neurons

Cells
Neurons are central to lifelong learning and memory, but ageing disrupts their morphology and function, leading to cognitive decline. Although epigenetic mechanisms are known to play crucial roles in learning and memory, neuron-specific genome-wide ...
Brandon Signal, Andrew J. Phipps, Katherine A. Giles, Shannon N. Huskins, Timothy R. Mercer, Mark D. Robinson, Adele Woodhouse, Phillippa C. Taberlay   +7 more
doaj   +1 more source

Blood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma

Journal of Emergencies, Trauma and Shock, 2013
Background: Tissue injury increases blood levels of extracellular histones and nucleic acids, and these may influence hemostasis, promote inflammation and damage the endothelium. Trauma-induced coagulopathy (TIC) may result from an endogenous response to
Pär I Johansson, Nis A Windeløv, Lars S Rasmussen, Anne Marie Sørensen, Sisse R Ostrowski   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Hansemann’s anaplastic theory of cancer after 135 years

Frontiers in Epigenetics and Epigenomics
Summary: The term “anaplasia” was coined in 1890 to describe chromosomal changes common to primordial cancer cells, but ever since the mechanisms whereby a cell becomes anaplastic has been the subject of much speculation.
Steven Henikoff, Steven Henikoff, Kami Ahmad   +2 more
doaj   +1 more source

Transcriptional and Post-Transcriptional Regulation and Transcriptional Memory of Chromatin Regulators in Response to Low Temperature

Frontiers in Plant Science, 2020
Chromatin regulation ensures stable repression of stress-inducible genes under non-stress conditions and transcriptional activation and memory of stress-related genes after stress exposure.
Kora Vyse, Léa Faivre, Melissa Romich, Majken Pagter, Daniel Schubert, Dirk K. Hincha, Ellen Zuther   +6 more
doaj   +1 more source

The Histone Database [PDF]

Nucleic Acids Research, 2002
Histone proteins are often noted for their high degree of sequence conservation. It is less often recognized that the histones are a heterogeneous protein family. Furthermore, several classes of non-histone proteins containing the histone fold motif exist.
Steven A. Sullivan, Daniel W. Sink, Kenneth L. Trout, Izabela Makalowska, Patrick M. Taylor, Andreas D. Baxevanis, David Landsman   +6 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Why are histones dynamic?

, 2015
Afin de pouvoir être contenu dans le noyau des cellules eucaryotes, l'ADN doit être compacté en un ensemble très structuré. L'ADN eucaryote est généralement associé à des protéines, principalement à des histones, pour former cette structure très compact ...
Ferrari, Paolo
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Artificial intelligence meets epigenetics: a new frontier in precision oncology

Epigenetics Reports
Epigenetics involves heritable and stable changes in gene expression that occur without altering the DNA sequence, primarily through chemical modifications to DNA and alterations in chromatin structure.
Ruby Srivastava
doaj   +1 more source