Results 1 to 10 of about 11,466,555 (302)

Cell specific post-translational processing of pikachurin, a protein involved in retinal synaptogenesis. [PDF]

PLoS ONE, 2012
Pikachurin is a recently identified, highly conserved, extracellular matrix-like protein. Murine pikachurin has 1,017 amino acids (~110 kDa), can bind to α-dystroglycan, and has been found to localize mainly in the synaptic cleft of photoreceptor ribbon ...
Jianzhong Han, Ellen Townes-Anderson
doaj   +4 more sources

From chromatin to proteostasis: multilevel gene regulation in Mendelian diseases [PDF]

Frontiers in Epigenetics and Epigenomics
Pathogenic variation can alter gene output at multiple levels, from chromatin accessibility and enhancer-promoter communication to RNA processing, translation and protein turnover.
Himanshu Goel, Himanshu Goel, Gunjan Garg   +2 more
doaj   +2 more sources

Beyond ER-Golgi trafficking: unconventional protein secretion as a new design frontier for synthetic secretion switches in mammalian cells [PDF]

Communications Biology
Mammalian gene switches enable programmable cell behavior. However, current switches on transcriptional and translational layers require de novo RNA and protein synthesis, and secreted outputs must additionally undergo folding, post-translational ...
Bingshun Shi, Xinyuan Qiu, Yongheng Jiang, Jiabo Cai, Lingyun Zhu   +4 more
doaj   +2 more sources

Novel 4D Tensor Decomposition-Based Approach Integrating Tri-Omics Profiling Data Can Identify Functionally Relevant Gene Clusters [PDF]

Biology
Understanding gene expression requires integrating multiple regulatory layers, because transcript abundance does not necessarily correspond to translational activity or protein abundance.
Turki Turki, Y.-H. Taguchi
doaj   +2 more sources

Analysis of pmpD expression and PmpD post-translational processing during the life cycle of Chlamydia trachomatis serovars A, D, and L2. [PDF]

PLoS ONE, 2009
BACKGROUND: The polymorphic membrane protein D (PmpD) in Chlamydia is structurally similar to autotransporter proteins described in other bacteria and may be involved in cellular and humoral protective immunity against Chlamydia.
Andrey O Kiselev, Megan C Skinner, Mary F Lampe   +2 more
doaj   +1 more source

The Role of Pumilio RNA Binding Protein in Plants

Biomolecules, 2021
Eukaryotic organisms have a posttranscriptional/translational regulation system for the control of translational efficiency. RNA binding proteins (RBPs) have been known to control target genes.
Sung Un Huh
doaj   +1 more source

PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

Journal of Experimental & Clinical Cancer Research, 2021
Background Murine xenografts of pediatric leukemia accurately recapitulate genomic aberrations. How this translates to the functional capacity of cells remains unclear. Here, we studied global protein abundance, phosphorylation, and protein maturation by
Anuli C. Uzozie, Enes K. Ergin, Nina Rolf, Janice Tsui, Amanda Lorentzian, Samuel S. H. Weng, Lorenz Nierves, Theodore G. Smith, C. James Lim, Christopher A. Maxwell, Gregor S. D. Reid, Philipp F. Lange   +11 more
doaj   +1 more source

The Impact of Endoplasmic Reticulum-Associated Protein Modifications, Folding and Degradation on Lung Structure and Function

Frontiers in Physiology, 2021
The accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and induces the unfolded protein response (UPR) and other mechanisms to restore ER homeostasis, including translational shutdown, increased targeting of ...
Emily M. Nakada, Emily M. Nakada, Rui Sun, Rui Sun, Utako Fujii, Utako Fujii, James G. Martin, James G. Martin   +7 more
doaj   +1 more source

Coordination of RNA Processing Regulation by Signal Transduction Pathways

Biomolecules, 2021
Signal transduction pathways transmit the information received from external and internal cues and generate a response that allows the cell to adapt to changes in the surrounding environment.
Veronica Ruta, Vittoria Pagliarini, Claudio Sette   +2 more
doaj   +1 more source

Molecular Dynamics Study of Citrullinated Proteins Associated with the Development of Rheumatoid Arthritis

Proteomes, 2022
Biological activity regulation by protein post-translational modification (PTM) is critical for cell function, development, differentiation, and survival.
Amir Taldaev, Vladimir Rudnev, Liudmila Kulikova, Kirill Nikolsky, Alexander Efimov, Kristina Malsagova, Anna Kaysheva   +6 more
doaj   +1 more source