Results 41 to 50 of about 11,466,555 (302)
Biosynthesis of intestinal microvillar proteins. The effect of swainsonine on post-translational processing of aminopeptidase N [PDF]
Biochemical Journal, 1983 The post-translational processing of pig small-intestinal aminopeptidase N (EC 3.4.11.2) was studied in organ-cultured mucosal explants. Exposure of the explants to swainsonine, an inhibitor of Golgi mannosidase II, resulted in the formation of a Mr-160000 polypeptide, still sensitive to endo-beta-N-acetylglucosaminidase H.
Danielsen, E M +4 more
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Automated assembly of molecular mechanisms at scale from text mining and curated databases
Molecular Systems Biology, 2023 The analysis of omic data depends on machine‐readable information about protein interactions, modifications, and activities as found in protein interaction networks, databases of post‐translational modifications, and curated models of gene and protein ...
John A Bachman +2 more
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Post-translational processing of chicken bone phosphoproteins. Identification of bone (phospho)protein kinase [PDF]
Biochemical Journal, 1990 We have detected a protein kinase which phosphorylates bone phosphoproteins (BPPs) in the detergent extract of the membranous fractions in the periosteal bone strips of 12-day-embryonic-chick tibia. This enzyme, tentatively named BPP kinase, has a catalytic subunit of Mr approximately 39,000, utilizes GTP as well as ATP as a phospho-group donor, is ...
Y, Mikuni-Takagaki, M J, Glimcher
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Cell Communication and Signaling, 2021 Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysiology. In this review, we put into context the
Zhu Liang +3 more
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Poly ADP-ribosylation of proteins. Processivity of a post-translational modification.
The Journal of biological chemistry, 1989 The nuclear enzyme poly(ADP-ribose) polymerase (EC 2.4.2.30) participates in DNA excision repair by post-translational selfmodification ("automodification") and the modification of other chromatin proteins ("heteromodification") with ADP-ribose polymers.
H, Naegeli, P, Loetscher, F R, Althaus
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Post-translational Modifications of the Protein Termini [PDF]
, 2021 Post-translational modifications (PTM) involve enzyme-mediated covalent addition of functional groups to proteins during or after synthesis. These modifications greatly increase biological complexity and are responsible for orders of magnitude change ...
Anna Kashina +3 more
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CellsPTCHD1 has been implicated in Autism Spectrum Disorders (ASDs) and/or intellectual disability, where copy-number-variant losses or loss-of-function coding mutations segregate with disease in an X-linked recessive fashion. Missense variants of PTCHD1 have
Connie T. Y. Xie +4 more
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STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications
Neoplasia: An International Journal for Oncology Research, 2021 The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is activated constitutively in a wide array of human cancers. It is an appealing molecular target for novel therapy as it directly regulates expression of genes
Isidora Tošić, David A. Frank
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New mechanism for post-translational processing during assembly of a cytoplasmic membrane protein? [PDF]
Journal of Bacteriology, 1981 Insertion of nitrate reductase into the Escherichia coli cytoplasmic membrane was examined by following the fate of pulse-labeled enzyme in both the membrane and cytoplasm during various times after the addition of an unlabeled chase. The polypeptide composition of this labeled enzyme was determined by autoradiography of immunoprecipitated material ...
C H, MacGregor, G E, McElhaney
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Rescue of Heart Failure by Mitochondrial Recovery [PDF]
International Neurourology Journal, 2016 Heart failure (HF) is a multifactorial disease brought about by numerous, and oftentimes complex, etiological mechanisms. Although well studied, HF continues to affect millions of people worldwide and current treatments can only prevent further ...
Jubert Marquez +3 more
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