Results 41 to 50 of about 244,545 (310)
Cell Communication and Signaling, 2021 Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysiology. In this review, we put into context the
Zhu Liang +3 more
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Poly ADP-ribosylation of proteins. Processivity of a post-translational modification.
The Journal of biological chemistry, 1989 The nuclear enzyme poly(ADP-ribose) polymerase (EC 2.4.2.30) participates in DNA excision repair by post-translational selfmodification ("automodification") and the modification of other chromatin proteins ("heteromodification") with ADP-ribose polymers.
H, Naegeli, P, Loetscher, F R, Althaus
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mRNA regulation in the "C. elegans" germ line [PDF]
, 2011 The C. elegans germ line relies heavily on post-transcriptional regulation of gene expression but the scale of mRNA regulation in the germ line is still unknown.
Scheckel, Claudia
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STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications
Neoplasia: An International Journal for Oncology Research, 2021 The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is activated constitutively in a wide array of human cancers. It is an appealing molecular target for novel therapy as it directly regulates expression of genes
Isidora Tošić, David A. Frank
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CellsPTCHD1 has been implicated in Autism Spectrum Disorders (ASDs) and/or intellectual disability, where copy-number-variant losses or loss-of-function coding mutations segregate with disease in an X-linked recessive fashion. Missense variants of PTCHD1 have
Connie T. Y. Xie +4 more
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How can platelet proteomics best be used to interrogate disease?
Platelets, 2023 Various modifications of proteins and the resulting proteoforms of a protein can associate with many diseases and are also significantly involved in the rapid regulation of hemostasis and thrombosis.
Maria Zellner
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Post-translational Modifications And Rna-binding Proteins [PDF]
, 2017 RNA-binding proteins affect cellular metabolic programs through development and in response to cellular stimuli. Though much work has been done to elucidate the roles of a handful of RNA-binding proteins and their effect on RNA metabolism, the progress ...
Mario H.; Massirer +3 more
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Glycosylation and S-palmitoylation regulate SARS-CoV-2 spike protein intracellular trafficking
iScience, 2022 Summary: Post-translational modifications (PTMs), such as glycosylation and palmitoylation, are critical to protein folding, stability, intracellular trafficking, and function.
Chih-Feng Tien +13 more
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New mechanism for post-translational processing during assembly of a cytoplasmic membrane protein? [PDF]
Journal of Bacteriology, 1981 Insertion of nitrate reductase into the Escherichia coli cytoplasmic membrane was examined by following the fate of pulse-labeled enzyme in both the membrane and cytoplasm during various times after the addition of an unlabeled chase. The polypeptide composition of this labeled enzyme was determined by autoradiography of immunoprecipitated material ...
C H, MacGregor, G E, McElhaney
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miRNA-Dependent Translational Repression in the Drosophila Ovary [PDF]
, 2009 Background: The Drosophila ovary is a tissue rich in post-transcriptional regulation of gene expression. Many of the regulatory factors are proteins identified via genetic screens.
Snee, Mark J. +8 more
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