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Regulation of the microprocessor by post-translational modifications [PDF]
Frontiers in Cell and Developmental BiologyThe Microprocessor is an essential protein complex that is responsible for the first processing step in the biogenesis of canonical microRNAs. The core of this complex is composed of two proteins, the ribonuclease III enzyme DROSHA and its double ...
Ka Weng Leong +3 more
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Post‐Translational Modifications in Animal Circadian Clocks [PDF]
Advanced ScienceThe circadian clock is a fundamental biological system that synchronizes behavioral and physiological processes such as metabolism and immunity with the 24 h day‐night cycle.
Xianhui Liu, Yong Zhang
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Post-Translational Modifications and Diabetes
BiomoleculesDiabetes and its associated complications have increasingly become major challenges for global healthcare. The current therapeutic strategies involve insulin replacement therapy for type 1 diabetes (T1D) and small-molecule drugs for type 2 diabetes (T2D).
Chiranjeev Sharma +4 more
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Post-Translational Modifications That Drive Prostate Cancer Progression [PDF]
Biomolecules, 2021 While a protein primary structure is determined by genetic code, its specific functional form is mostly achieved in a dynamic interplay that includes actions of many enzymes involved in post-translational modifications.
Ivana Samaržija
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Post-translational modifications of exosomal proteins
Frontiers in Immunology, 2014 Exosomes mediate intercellular communication and participate in many cell processes such as cancer progression, immune activation or evasion, and the spread of infection.
Olga eMoreno-Gonzalo +2 more
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Post-translational Modifications of the Protein Termini [PDF]
Frontiers in Cell and Developmental Biology, 2021 Post-translational modifications (PTM) involve enzyme-mediated covalent addition of functional groups to proteins during or after synthesis. These modifications greatly increase biological complexity and are responsible for orders of magnitude change ...
Li Chen, Anna Kashina
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Post-translational modifications of microtubules [PDF]
Journal of Cell Science, 2010 Microtubules – polymers of tubulin – perform essential functions, including regulation of cell shape, intracellular transport and cell motility. How microtubules are adapted to perform multiple diverse functions is not well understood. Post-translational
Jacek Gaertig, Dorota Wloga
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Post-Translational Modifications of Extracellular Proteasome [PDF]
Molecules, 2020 The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways in eukaryotic cells. Abnormal functioning of this system has been observed in cancer and neurological diseases.
Anna S. Tsimokha +4 more
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Post‐Translational Modifications in Cilia and Ciliopathies [PDF]
Advanced ScienceCilia are microtubule‐based organelles that extend from the surface of most vertebrate cells, and they play important roles in diverse cellular processes during embryonic development and tissue homeostasis.
Jie Ran, Jun Zhou
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Post-Translational Modifications of TRP Channels [PDF]
Cells, 2014 Transient receptor potential (TRP) channels constitute an ancient family of cation channels that have been found in many eukaryotic organisms from yeast to human.
Olaf Voolstra, Armin Huber
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