Results 1 to 10 of about 274,920 (356)
KLHL12 promotes non-lysine ubiquitination of the dopamine receptors D-4.2 and D-4.4, but not of the ADHD-associated D-4.7 variant [PDF]
, 2015 Dopamine D-4 Receptor Polymorphism : The dopamine D-4 receptor has an important polymorphism in its third intracellular loop that is intensively studied and has been associated with several abnormal conditions, among others, attention deficit ...
Lintermans, Béatrice +3 more
core +12 more sources
PLoS ONE, 2021 Signaling by the Rho GTPase Rac1 is key to the regulation of cytoskeletal dynamics, cell spreading and adhesion. It is widely accepted that the inactive form of Rac1 is bound by Rho GDI, which prevents Rac1 activation and Rac1-effector interactions.
Jisca Majolée +3 more
doaj +1 more source
Structural propensities of human ubiquitination sites: accessibility, centrality and local conformation. [PDF]
PLoS ONE, 2013 The existence and function of most proteins in the human proteome are regulated by the ubiquitination process. To date, tens of thousands human ubiquitination sites have been identified from high-throughput proteomic studies.
Yuan Zhou +3 more
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Emerging Roles of Non-proteolytic Ubiquitination in Tumorigenesis
Frontiers in Cell and Developmental Biology, 2022 Ubiquitination is a critical type of protein post-translational modification playing an essential role in many cellular processes. To date, more than eight types of ubiquitination exist, all of which are involved in distinct cellular processes based on ...
Xiu Yin +8 more
doaj +1 more source
Cell & Bioscience, 2022 Ubiquitination is a versatile post-translational modification (PTM), which regulates diverse fundamental features of protein substrates, including stability, activity, and localization.
Mingwei Sun, Xiaofei Zhang
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Cellular functions and molecular mechanisms of non-lysine ubiquitination [PDF]
Open Biology, 2019 Protein ubiquitination is of great cellular importance through its central role in processes such as degradation, DNA repair, endocytosis and inflammation.
Amie J. McClellan +2 more
doaj +1 more source
Tau Ubiquitination in Alzheimer's Disease
Frontiers in Neurology, 2022 Paired helical filaments (PHFs) from the Alzheimer's disease (AD) brain are highly ubiquitinated and ubiquitination likely plays a vital role in tau filament formation.
Longfei Li +8 more
doaj +1 more source
Role of K63-linked ubiquitination in cancer
Cell Death Discovery, 2022 Ubiquitination is a critical type of post-translational modifications, of which K63-linked ubiquitination regulates interaction, translocation, and activation of proteins.
Liangzi Cao +4 more
doaj +1 more source
Ligand-induced monoubiquitination of BIK1 regulates plant immunity [PDF]
, 2020 The detection of microorganism-associated ligands by plant cells activates a signalling cascade in which the kinase BIK1 is monoubiquinated, released from the FLS2-BAK1 complex, and internalized by endocytosis. Recognition of microbe-associated molecular
Alves Neubus Claus, Lucas +15 more
core +1 more source
Frontiers in Plant Science, 2018 Reversible protein ubiquitination plays essential roles in regulating cellular processes. Although many reports have described the functions of ubiquitination in plant defense responses, few have focused on global changes in the ubiquitome.
Xiao-Lin Chen +10 more
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