Results 1 to 10 of about 22,435 (241)
Ubiquitination and Deubiquitination in Oral Disease [PDF]
International Journal of Molecular Sciences, 2021 Oral health is an integral part of the general health and well-being of individuals. The presence of oral disease is potentially indicative of a number of systemic diseases and may contribute to their early diagnosis and treatment. The ubiquitin (Ub) system has been shown to play a role in cellular immune response, cellular development, and programmed ...
Sachio Tsuchida, Tomohiro Nakayama
exaly +4 more sources
Ubiquitination and deubiquitination as critical modulators of NSCLC tumorigenesis and drug resistance [PDF]
Discover OncologyUbiquitination and deubiquitination are biological mechanisms that including the addition and removal ubiquitin molecules from proteins, which are associated with NSCLC.
Prasanna Srinivasan Ramalingam +12 more
doaj +3 more sources
Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats
Heliyon, 2023 This experiment was designed to explore the effect and mechanism of electroacupuncture (EA) for hyperlipidemia and hepatic cholesterol synthesis in rats.
Shu-wen Jin +3 more
doaj +2 more sources
Translational Oncology, 2023 Aberrant expression of deubiquitinases (DUBs) is significantly associated with tumorigenesis. However, the precise impact of deubiquitination on the tumour microenvironment (TME) and immunotherapy in hepatocellular carcinoma (HCC) remains unclear.
Jiahao Zhang +10 more
doaj +2 more sources
Characterization of the deubiquitination activity and substrate specificity of the chicken ubiquitin-specific protease 1/USP associated factor 1 complex. [PDF]
PLoS ONE, 2017 Deubiquitinases (DUBs) are essential regulators of intracellular processes involving ubiquitin (Ub) modification. The human DUB ubiquitin-specific protease 1 (hUSP1) interacts with human USP-associated factor 1 (hUAF1), and helps to regulate processes ...
Hainan Zheng +7 more
doaj +2 more sources
The role of ubiquitination and deubiquitination in cancer lipid metabolism
Frontiers in OncologyThe ubiquitin-proteasome system (UPS) is one of the main degradation systems within cells, catalyzing the tagging of proteins for degradation by ubiquitin molecules, which are then recognized and degraded by the proteasome.
Si Tao, Jianbing Wu, Yongkang Xu
exaly +3 more sources
Elucidating the role of ubiquitination and deubiquitination in osteoarthritis progression
Frontiers in Immunology, 2023 Osteoarthritis is non-inflammatory degenerative joint arthritis, which exacerbates disability in elder persons. The molecular mechanisms of osteoarthritis are elusive. Ubiquitination, one type of post-translational modifications, has been demonstrated to
Peter Wang, Yurui Wu
exaly +3 more sources
Frontiers in Oncology, 2023 Lung cancer (LC) remains the leading cause of cancer-related deaths worldwide, with extremely high morbidity and mortality rates. Non-small cell lung cancer (NSCLC) is the most critical type of LC.
Yiyang Sun, Ping He, Li Li, Xue Ding
doaj +1 more source
Deubiquitinating Enzymes in Parkinson’s Disease [PDF]
Frontiers in Physiology, 2020 La disfunción mitocondrial y la neurodegeneración se han correlacionado directamente en muchos trastornos neurodegenerativos. La enfermedad de Parkinson (EP) en particular se ha estudiado ampliamente en este contexto debido a su asociación bien caracterizada con la mitofagia, un tipo selectivo de autofagia que degrada las mitocondrias.
Joy Chakraborty, Elena Ziviani
openaire +3 more sources
Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells
Microbiology Spectrum, 2021 Chronic hepatitis C virus (HCV) infection induces liver inflammation that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Inflammation is the outcome of the action of proinflammatory cytokines and chemokines, including interleukin-1 ...
Akshaya Ramachandran +3 more
doaj +1 more source