Results 1 to 10 of about 19,691 (163)
Ubiquitination and deubiquitination as critical modulators of NSCLC tumorigenesis and drug resistance [PDF]
Discover OncologyUbiquitination and deubiquitination are biological mechanisms that including the addition and removal ubiquitin molecules from proteins, which are associated with NSCLC.
Prasanna Srinivasan Ramalingam +12 more
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Biomedicines, 2023 Radiotherapy, a treatment method employing radiation to eradicate tumor cells and subsequently reduce or eliminate tumor masses, is widely applied in the management of numerous patients with tumors.
Gu Wendong, Shao Yingjie
exaly +3 more sources
Acta Pharmaceutica Sinica B, 2023 Deubiquitinating enzymes (DUBs) or deubiquitinases facilitate the escape of multiple proteins from ubiquitin‒proteasome degradation and are critical for regulating protein expression levels in vivo. Therefore, dissecting the underlying mechanism of DUB recognition is needed to advance the development of drugs related to DUB signaling pathways. To data,
Qiaojun He, Ji Cao, Yizheng Fang
exaly +4 more sources
Frontiers in Cellular and Infection MicrobiologyIntroductionProtein homeostasis is maintained by the opposing action of ubiquitin ligase and deubiquitinase, two important components of the ubiquitin-proteasome pathway, and contributes to both normal physiological and pathophysiological processes.
Johnny He, He Johnny J
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The role of ubiquitination and deubiquitination in cancer lipid metabolism
Frontiers in OncologyThe ubiquitin-proteasome system (UPS) is one of the main degradation systems within cells, catalyzing the tagging of proteins for degradation by ubiquitin molecules, which are then recognized and degraded by the proteasome.
Jianbing Wu, Wu Jianbing, Xu Yongkang
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Translational Oncology, 2023 Aberrant expression of deubiquitinases (DUBs) is significantly associated with tumorigenesis. However, the precise impact of deubiquitination on the tumour microenvironment (TME) and immunotherapy in hepatocellular carcinoma (HCC) remains unclear.
Jiahao Zhang +10 more
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Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats
Heliyon, 2023 This experiment was designed to explore the effect and mechanism of electroacupuncture (EA) for hyperlipidemia and hepatic cholesterol synthesis in rats.
Shu-wen Jin +3 more
doaj +1 more source
Deubiquitinating Enzymes in Parkinson’s Disease [PDF]
Frontiers in Physiology, 2020 La disfunción mitocondrial y la neurodegeneración se han correlacionado directamente en muchos trastornos neurodegenerativos. La enfermedad de Parkinson (EP) en particular se ha estudiado ampliamente en este contexto debido a su asociación bien caracterizada con la mitofagia, un tipo selectivo de autofagia que degrada las mitocondrias.
Joy Chakraborty, Elena Ziviani
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Characterization of the deubiquitination activity and substrate specificity of the chicken ubiquitin-specific protease 1/USP associated factor 1 complex. [PDF]
PLoS ONE, 2017 Deubiquitinases (DUBs) are essential regulators of intracellular processes involving ubiquitin (Ub) modification. The human DUB ubiquitin-specific protease 1 (hUSP1) interacts with human USP-associated factor 1 (hUAF1), and helps to regulate processes ...
Hainan Zheng +7 more
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Frontiers in Oncology, 2023 Lung cancer (LC) remains the leading cause of cancer-related deaths worldwide, with extremely high morbidity and mortality rates. Non-small cell lung cancer (NSCLC) is the most critical type of LC.
Yiyang Sun, Ping He, Li Li, Xue Ding
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