Results 1 to 10 of about 28,234 (247)

Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1 [PDF]

Life Science Alliance, 2018
Deubiquitination of FANCD2, FANCI, and PCNA by USP1 is essential for DNA repair signalling. Reconstitution of the system reveals that USP1-mediated specificity towards K561 of FANCD2 is directed by a unique sequence at USP1's N-terminus.
Connor Arkinson, Viduth K Chaugule, Rachel Toth, Helen Walden   +3 more
doaj   +2 more sources

UBP12 and UBP13 negatively regulate the activity of the ubiquitin-dependent peptidases DA1, DAR1 and DAR2 [PDF]

eLife, 2020
Protein ubiquitination is a very diverse post-translational modification leading to protein degradation or delocalization, or altering protein activity. In Arabidopsis thaliana, two E3 ligases, BIG BROTHER (BB) and DA2, activate the latent peptidases DA1,
Hannes Vanhaeren, Ying Chen, Mattias Vermeersch, Liesbeth De Milde, Valerie De Vleeschhauwer, Annelore Natran, Geert Persiau, Dominique Eeckhout, Geert De Jaeger, Kris Gevaert, Dirk Inzé   +10 more
doaj   +2 more sources

Ubiquitination and deubiquitination as critical modulators of NSCLC tumorigenesis and drug resistance [PDF]

Discover Oncology
Ubiquitination and deubiquitination are biological mechanisms that including the addition and removal ubiquitin molecules from proteins, which are associated with NSCLC.
Prasanna Srinivasan Ramalingam, Mohammad Afzal, Manjunath Mirle Rekha, Samir Sahoo, Surya Nath Pandey, Chandana Maji, Kavita Goyal, Haider Ali, Sachin Kumar Singh, Gaurav Gupta, Md. Sadique Hussain, Purushothaman Balakrishnan, Sivakumar Arumugam   +12 more
doaj   +2 more sources

The Mechanism of Ubiquitination or Deubiquitination Modifications in Regulating Solid Tumor Radiosensitivity

Biomedicines, 2023
Radiotherapy, a treatment method employing radiation to eradicate tumor cells and subsequently reduce or eliminate tumor masses, is widely applied in the management of numerous patients with tumors.
Yingjie Shao, Shao Yingjie, Gu Wendong   +2 more
exaly   +3 more sources

Ectopic USP15 expression inhibits HIV-1 transcription involving changes in YY1 deubiquitination and stability

Frontiers in Cellular and Infection Microbiology
IntroductionProtein homeostasis is maintained by the opposing action of ubiquitin ligase and deubiquitinase, two important components of the ubiquitin-proteasome pathway, and contributes to both normal physiological and pathophysiological processes.
Johnny J He, He Johnny J
exaly   +3 more sources

The role of ubiquitination and deubiquitination in cancer lipid metabolism

Frontiers in Oncology
The ubiquitin-proteasome system (UPS) is one of the main degradation systems within cells, catalyzing the tagging of proteins for degradation by ubiquitin molecules, which are then recognized and degraded by the proteasome.
Yongkang Xu, Jianbing Wu, Xu Yongkang
exaly   +3 more sources

Silencing of USP22 promotes FGF11 degradation to attenuates renal fibrosis in diabetic kidney disease [PDF]

Renal Failure
Objectives: Diabetic kidney disease (DKD) is a major cause of end-stage renal disease that is characterized by renal fibrosis. Fibroblast growth factor 11 (FGF11) is reported to be involved in mesangial cell fibrosis; however, its mechanism is not fully ...
Zhigang Wang, Chao Liu, Jing Lv, Jiping Sun, Xiaoyang Yu, Huixian Li   +5 more
doaj   +2 more sources

A Novel Scoring Model of Deubiquitination Patterns Predicts Prognosis and Immunotherapeutic Response in Hepatocellular Carcinoma

Translational Oncology, 2023
Aberrant expression of deubiquitinases (DUBs) is significantly associated with tumorigenesis. However, the precise impact of deubiquitination on the tumour microenvironment (TME) and immunotherapy in hepatocellular carcinoma (HCC) remains unclear.
Jiahao Zhang, Gefeng Wu, Rui Peng, Jun Cao, Daoyuan Tu, Jie Zhou, Bingbing Su, Shengjie Jin, Guoqing Jiang, Chi Zhang, Dousheng Bai   +10 more
doaj   +1 more source

Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats

Heliyon, 2023
This experiment was designed to explore the effect and mechanism of electroacupuncture (EA) for hyperlipidemia and hepatic cholesterol synthesis in rats.
Shu-wen Jin, Yong-li Han, Xiao-li Pan, Hong-xing Zhang   +3 more
doaj   +1 more source

Deubiquitinating Enzymes in Parkinson’s Disease [PDF]

Frontiers in Physiology, 2020
La disfunción mitocondrial y la neurodegeneración se han correlacionado directamente en muchos trastornos neurodegenerativos. La enfermedad de Parkinson (EP) en particular se ha estudiado ampliamente en este contexto debido a su asociación bien caracterizada con la mitofagia, un tipo selectivo de autofagia que degrada las mitocondrias.
Joy Chakraborty, Elena Ziviani
openaire   +3 more sources