Results 21 to 30 of about 28,234 (247)

The emerging role of Deubiquitinases (DUBs) in parasites: A foresight review

Frontiers in Cellular and Infection Microbiology, 2022
Before the discovery of the proteasome complex, the lysosomes with acidic proteases and caspases in apoptotic pathways were thought to be the only pathways for the degradation of damaged, unfolded, and aged proteins. However, the discovery of 26S and 20S
Prakash Kumar, Pawan Kumar, Debabrata Mandal, Ravichandiran Velayutham, Ravichandiran Velayutham   +4 more
doaj   +1 more source

Deubiquitinating enzymes as oncotargets

Oncotarget, 2015
Carcinogenesis is a complex process tightly regulated at multiple levels by post-translational modifications. Epigenetics plays a major role in cancer development, all stable changes to the gene expression process that are not a result of a direct change in the DNA code are described as epigenetics.
McClurg UL, Robson CN
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Deubiquitination and Activation of AMPK by USP10 [PDF]

Molecular Cell, 2016
The AMP-activated protein kinase (AMPK) is the master regulator of metabolic homeostasis by sensing cellular energy status. When intracellular ATP levels decrease during energy stress, AMPK is initially activated through AMP or ADP binding and phosphorylation of a threonine residue (Thr-172) within the activation loop of its kinase domain.
Deng, Min, Yang, Xu, Qin, Bo, Liu, Tongzheng, Zhang, Haoxing, Guo, Wei, Lee, Seung Baek, Kim, Jung Jin, Yuan, Jian, Pei, Huadong, Wang, Liewei, Lou, Zhenkun   +11 more
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The Molecular Basis of Spinocerebellar Ataxia Type 7

Frontiers in Neuroscience, 2022
Spinocerebellar ataxia (SCA) type 7 (SCA7) is caused by a CAG trinucleotide repeat expansion in the ataxin 7 (ATXN7) gene, which results in polyglutamine expansion at the amino terminus of the ATXN7 protein.
Rituparna Goswami, Abudu I. Bello, Joe Bean, Kara M. Costanzo, Bwaar Omer, Dayanne Cornelio-Parra, Revan Odah, Amit Ahluwalia, Shefaa K. Allan, Nghi Nguyen, Taylor Shores, N. Ahmad Aziz, Ryan D. Mohan   +12 more
doaj   +1 more source

Enzymes of ubiquitination and deubiquitination

Essays in Biochemistry, 2012
Ubiquitination, the covalent attachment of the small protein modifier ubiquitin to a substrate protein is involved in virtually all cellular processes by mediating the regulated degradation of proteins. Aside from proteasomal degradation, ubiquitination plays important roles in transcriptional regulation, protein trafficking, including endocytosis and ...
Neutzner, M., Neutzner, A.
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Deubiquitinating Function of Adenovirus Proteinase [PDF]

Journal of Virology, 2002
ABSTRACT The invasion strategy of many viruses involves the synthesis of viral gene products that mimic the functions of the cellular proteins and thus interfere with the key cellular processes. Here we show that adenovirus infection is accompanied by an increased ubiquitin-cleaving (deubiquitinating) activity in the host cells.
Maxim Y, Balakirev, Michel, Jaquinod, Arthur L, Haas, Jadwiga, Chroboczek   +3 more
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ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2

Frontiers in Cell and Developmental Biology, 2020
DNA interstrand crosslinks (ICLs) are a physical barrier to replication and therefore toxic to cell viability. An important mechanism for the removal of ICLs is the Fanconi Anemia DNA repair pathway, which is initiated by mono-ubiquitination of FANCD2 ...
Winnie Tan, Winnie Tan, Sylvie van Twest, Vincent J. Murphy, Andrew J. Deans, Andrew J. Deans   +5 more
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PSMC3 promotes RNAi by maintaining AGO2 stability through USP14

Cellular & Molecular Biology Letters, 2022
Background Argonaute 2 (AGO2), the only protein with catalytic activity in the human Argonaute family, is considered as a key component of RNA interference (RNAi) pathway.
Yan Jia, Jianing Zhao, Tao Yu, Xue Zhang, Xiaozhen Qi, Tongxin Hao, Zeyuan Jin, Xiaoqing Zhao   +7 more
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USP14 promotes pyroptosis of human annulus fibrosus cells derived from patients with intervertebral disc degeneration through deubiquitination of NLRP3

Acta Biochimica et Biophysica Sinica, 2022
Intervertebral disc degeneration (IVDD) is a general disorder that results in low back pain and disability among many affected individuals. However, the current treatments for IVDD are limited to relieving the symptoms but do not solve the fundamental ...
Hai Bao, Mao Tianli, Du Chuanchao, Jia Fei, Liu Yu, Song Qingpeng, Pan Xiaoyu, Liu Xiaoguang, Zhu Bin   +8 more
doaj   +1 more source

Navigating the Deubiquitinating Proteome with a ComPASS [PDF]

Cell, 2009
Deubiquitinating enzymes (DUBs) act on ubiquitinated substrates to regulate their modification and stability. In this issue, Sowa et al. (2009) present a comprehensive proteomic analysis of DUB interacting proteins in humans and a new quantitative scoring system for hits (CompPASS), providing a resource that links DUBs to biological pathways.
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