Results 21 to 30 of about 22,435 (241)
Mechanism, specificity and function of FANCD2‐FANCI ubiquitination and deubiquitination [PDF]
, 2022 Fanconi anemia (FA) is a rare genetic disorder caused by mutations in any of the currently 22 known FA genes. The products of these genes, along with other FA associated proteins, participate in a biochemical pathway, known as the FA pathway.
Rennie, Martin L. +7 more
core +1 more source
Frontiers in Oncology, 2022 Ubiquitin-specific peptidase 10 (USP10) is a member of the ubiquitin-specific protease family that removes the ubiquitin chain from ubiquitin-conjugated protein substrates.
Ziqi Ye +7 more
doaj +1 more source
The emerging role of Deubiquitinases (DUBs) in parasites: A foresight review
Frontiers in Cellular and Infection Microbiology, 2022 Before the discovery of the proteasome complex, the lysosomes with acidic proteases and caspases in apoptotic pathways were thought to be the only pathways for the degradation of damaged, unfolded, and aged proteins. However, the discovery of 26S and 20S
Prakash Kumar +4 more
doaj +1 more source
The Molecular Basis of Spinocerebellar Ataxia Type 7
Frontiers in Neuroscience, 2022 Spinocerebellar ataxia (SCA) type 7 (SCA7) is caused by a CAG trinucleotide repeat expansion in the ataxin 7 (ATXN7) gene, which results in polyglutamine expansion at the amino terminus of the ATXN7 protein.
Rituparna Goswami +12 more
doaj +1 more source
Deubiquitinating enzymes as oncotargets
Oncotarget, 2015 Carcinogenesis is a complex process tightly regulated at multiple levels by post-translational modifications. Epigenetics plays a major role in cancer development, all stable changes to the gene expression process that are not a result of a direct change in the DNA code are described as epigenetics.
McClurg UL, Robson CN
openaire +4 more sources
ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2
Frontiers in Cell and Developmental Biology, 2020 DNA interstrand crosslinks (ICLs) are a physical barrier to replication and therefore toxic to cell viability. An important mechanism for the removal of ICLs is the Fanconi Anemia DNA repair pathway, which is initiated by mono-ubiquitination of FANCD2 ...
Winnie Tan +5 more
doaj +1 more source
PSMC3 promotes RNAi by maintaining AGO2 stability through USP14
Cellular & Molecular Biology Letters, 2022 Background Argonaute 2 (AGO2), the only protein with catalytic activity in the human Argonaute family, is considered as a key component of RNA interference (RNAi) pathway.
Yan Jia +7 more
doaj +1 more source
Acta Biochimica et Biophysica Sinica, 2022 Intervertebral disc degeneration (IVDD) is a general disorder that results in low back pain and disability among many affected individuals. However, the current treatments for IVDD are limited to relieving the symptoms but do not solve the fundamental ...
Hai Bao +8 more
doaj +1 more source
Enzymes of ubiquitination and deubiquitination
Essays in Biochemistry, 2012 Ubiquitination, the covalent attachment of the small protein modifier ubiquitin to a substrate protein is involved in virtually all cellular processes by mediating the regulated degradation of proteins. Aside from proteasomal degradation, ubiquitination plays important roles in transcriptional regulation, protein trafficking, including endocytosis and ...
Neutzner, M., Neutzner, A.
openaire +4 more sources
Protein partners of deubiquitinating enzymes [PDF]
Biochemical Journal, 2008 Protein modification by ubiquitin and ubiquitin-like molecules is a critical regulatory process. Like most regulated protein modifications, ubiquitination is reversible. Deubiquitination, the reversal of ubiquitination, is quickly being recognized as an important regulatory strategy.
Karen H, Ventii, Keith D, Wilkinson
openaire +2 more sources