Results 21 to 30 of about 19,734 (206)
ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2
Frontiers in Cell and Developmental Biology, 2020 DNA interstrand crosslinks (ICLs) are a physical barrier to replication and therefore toxic to cell viability. An important mechanism for the removal of ICLs is the Fanconi Anemia DNA repair pathway, which is initiated by mono-ubiquitination of FANCD2 ...
Winnie Tan +5 more
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PSMC3 promotes RNAi by maintaining AGO2 stability through USP14
Cellular & Molecular Biology Letters, 2022 Background Argonaute 2 (AGO2), the only protein with catalytic activity in the human Argonaute family, is considered as a key component of RNA interference (RNAi) pathway.
Yan Jia +7 more
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Acta Biochimica et Biophysica Sinica, 2022 Intervertebral disc degeneration (IVDD) is a general disorder that results in low back pain and disability among many affected individuals. However, the current treatments for IVDD are limited to relieving the symptoms but do not solve the fundamental ...
Hai Bao +8 more
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Bacterial Interference of Ubiquitination and Deubiquitination [PDF]
Cell Host & Microbe, 2007 Ubiquitination and deubiquitination regulate several essential cellular processes such as protein degradation, cell-cycle progression, signaling, and DNA repair. Given the importance of these processes, it is not surprising that many microbes have developed the means to interfere with different stages of ubiquitin pathways to promote their survival and
Rytkönen, Anne, Holden, David W.
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Enzymes of ubiquitination and deubiquitination
Essays in Biochemistry, 2012 Ubiquitination, the covalent attachment of the small protein modifier ubiquitin to a substrate protein is involved in virtually all cellular processes by mediating the regulated degradation of proteins. Aside from proteasomal degradation, ubiquitination plays important roles in transcriptional regulation, protein trafficking, including endocytosis and ...
Neutzner, M., Neutzner, A.
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Deubiquitination and Activation of AMPK by USP10 [PDF]
Molecular Cell, 2016 The AMP-activated protein kinase (AMPK) is the master regulator of metabolic homeostasis by sensing cellular energy status. When intracellular ATP levels decrease during energy stress, AMPK is initially activated through AMP or ADP binding and phosphorylation of a threonine residue (Thr-172) within the activation loop of its kinase domain.
Deng, Min +11 more
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Protein partners of deubiquitinating enzymes [PDF]
Biochemical Journal, 2008 Protein modification by ubiquitin and ubiquitin-like molecules is a critical regulatory process. Like most regulated protein modifications, ubiquitination is reversible. Deubiquitination, the reversal of ubiquitination, is quickly being recognized as an important regulatory strategy.
Karen H, Ventii, Keith D, Wilkinson
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Endocytosis: Why not wait to deubiquitinate? [PDF]
Current Biology, 2000 Deubiquitination by the Fat facets protein - a regulator of photoreceptor differentiation during Drosophila eye development - has been found to activate endocytosis, while ubiquitination inhibits endocytosis. Surprisingly, this is the opposite effect that ubiquitination has on endocytosis of many plasma membrane proteins.
Carthew, Richard W., Xu, Chunyan
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Navigating the Deubiquitinating Proteome with a ComPASS [PDF]
Cell, 2009 Deubiquitinating enzymes (DUBs) act on ubiquitinated substrates to regulate their modification and stability. In this issue, Sowa et al. (2009) present a comprehensive proteomic analysis of DUB interacting proteins in humans and a new quantitative scoring system for hits (CompPASS), providing a resource that links DUBs to biological pathways.
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Deubiquitinating Function of Adenovirus Proteinase [PDF]
Journal of Virology, 2002 ABSTRACT The invasion strategy of many viruses involves the synthesis of viral gene products that mimic the functions of the cellular proteins and thus interfere with the key cellular processes. Here we show that adenovirus infection is accompanied by an increased ubiquitin-cleaving (deubiquitinating) activity in the host cells.
Maxim Y, Balakirev +3 more
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