Ubiquitin-Specific Proteases: Players in Cancer Cellular Processes [PDF]
Pharmaceuticals, 2021 Ubiquitination represents a post-translational modification (PTM) essential for the maintenance of cellular homeostasis. Ubiquitination is involved in the regulation of protein function, localization and turnover through the attachment of a ubiquitin ...
Paula Soares, Correia M
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Roles of ubiquitin-specific proteases in inflammatory diseases [PDF]
Frontiers in ImmunologyUbiquitin-specific proteases (USPs), as one of the deubiquitinating enzymes (DUBs) families, regulate the fate of proteins and signaling pathway transduction by removing ubiquitin chains from the target proteins.
Yanjun Liu, Linke Li
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An insight into the roles of ubiquitin-specific proteases in plants: development and growth, morphogenesis, and stress response [PDF]
Frontiers in Plant ScienceUbiquitination is a highly conserved and dynamic post-translational modification in which protein substrates are modified by ubiquitin to influence their activity, localization, or stability. Deubiquitination enzymes (DUBs) counter ubiquitin signaling by
Liang Du
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Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619 [PDF]
Cells, 2021 Osteosarcoma (OS) is the most common malignant bone tumor in children and teenagers. In many cases, such as poor response to treatment or the presence of metastases at diagnosis, the survival rate of patients remains very low. Although in the literature,
Benjamin Ory +2 more
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Inhibition of Ubiquitin-Specific Proteases as a Novel Anticancer Therapeutic Strategy [PDF]
Frontiers in Pharmacology, 2018 Dysfunction or dysregulation of the ubiquitin proteasome system (UPS) is closely related to tumorigenesis and the development of multiple cancers. Targeting the UPS provides a new anticancer therapeutic strategy, but clinically available UPS-targeted ...
Qiaojun He, Hong Zhu, Xuejing Shao
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Ubiquitin-Specific Proteases as Potential Therapeutic Targets in Bladder Cancer—In Vitro Evaluation of Degrasyn and PR-619 Activity Using Human and Canine Models [PDF]
Biomedicines, 2023 Background: The inhibition of ubiquitin-specific proteases (USPs) is a novel and promising direction in the development of molecularly targeted therapies in oncology.
Tomasz Szydełko +2 more
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Identification and Validation of Ubiquitin-Specific Proteases as a Novel Prognostic Signature for Hepatocellular Carcinoma [PDF]
Frontiers in Oncology, 2021 PurposeUbiquitin-specific proteases (USPs), as a sub-family of deubiquitinating enzymes (DUBs), are responsible for the elimination of ubiquitin-triggered modification. USPs are recently correlated with various malignancies.
Wenjie Zheng +2 more
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Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application [PDF]
Journal of Experimental & Clinical Cancer Research, 2023 Tumors have evolved in various mechanisms to evade the immune system, hindering the antitumor immune response and facilitating tumor progression. Immunotherapy has become a potential treatment strategy specific to different cancer types by utilizing ...
Hongli Gao +8 more
doaj +2 more sources
Ubiquitin-specific proteases in inflammatory bowel disease-related signalling pathway regulation [PDF]
Cell Death and Disease, 2022 The exact pathogenesis of inflammatory bowel disease (IBD), a chronic gastrointestinal inflammatory disease comprising Crohn’s disease and ulcerative colitis, remains unclear.
Rirong Chen +5 more
doaj +2 more sources
Spotlights on ubiquitin-specific proteases in lung cancer: from multifaceted pathophysiological mechanisms to potential therapeutic targets [PDF]
PeerJLung cancer ranks as the leading cause of cancer-related mortality worldwide, characterised by complex molecular mechanisms and high therapeutic resistance.
Xiaoyun Shen +7 more
doaj +3 more sources