Results 1 to 10 of about 1,825 (127)

Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application [PDF]

Journal of Experimental & Clinical Cancer Research, 2023
Tumors have evolved in various mechanisms to evade the immune system, hindering the antitumor immune response and facilitating tumor progression. Immunotherapy has become a potential treatment strategy specific to different cancer types by utilizing ...
Hongli Gao, Jianqiao Yin, Ce Ji, Xiaopeng Yu, Jinqi Xue, Xin Guan, Shuang Zhang, Xun Liu, Fei Xing   +8 more
doaj   +5 more sources

Drug resistance mechanisms and treatment strategies mediated by Ubiquitin-Specific Proteases (USPs) in cancers: new directions and therapeutic options [PDF]

Molecular Cancer
Drug resistance represents a significant obstacle in cancer treatment, underscoring the need for the discovery of novel therapeutic targets. Ubiquitin-specific proteases (USPs), a subclass of deubiquitinating enzymes, play a pivotal role in protein ...
Hongli Gao, Zhuo Xi, Jingwei Dai, Jinqi Xue, Xin Guan, Liang Zhao, Zhiguang Chen, Fei Xing   +7 more
doaj   +5 more sources

Ubiquitin-specific proteases (USPs) in leukemia: a systematic review [PDF]

BMC Cancer
Background Leukemia, a type of blood cell cancer, is categorized by the type of white blood cells affected (lymphocytes or myeloid cells) and disease progression (acute or chronic).
Alireza Zangooie, Shima Tavoosi, Mahan Arabhosseini, Aram Halimi, Helia Zangooie, Amir Hossein Baghsheikhi, Soheila Rahgozar, Mohammad Ahmadvand, Alireza Mosavi Jarrahi, Zahra Salehi   +9 more
doaj   +4 more sources

Molecular Mechanisms of the Ubiquitin-Specific Proteases (USPs) Family in Biliary Tract Cancer and Targeted Intervention Strategies [PDF]

Biomedicines
Biliary tract carcinoma (BTC) is a group of highly heterogeneous malignancies arising from the biliary epithelium. Anatomically, BTC is categorized into gallbladder cancer (GBC) and cholangiocarcinoma (CCA), with the latter further subdivided into ...
Qian Cheng, Delin Ma, Shengmin Zheng, Jialing Hao, Gang Wang, Yanbin Ni, Jiye Zhu   +6 more
doaj   +5 more sources

Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619 [PDF]

Cells, 2021
Osteosarcoma (OS) is the most common malignant bone tumor in children and teenagers. In many cases, such as poor response to treatment or the presence of metastases at diagnosis, the survival rate of patients remains very low. Although in the literature,
Mélanie Lavaud, Mathilde Mullard, Robel Tesfaye, Jérôme Amiaud, Mélanie Legrand, Geoffroy Danieau, Régis Brion, Sarah Morice, Laura Regnier, Maryne Dupuy, Bénédicte Brounais-Le Royer, François Lamoureux, Benjamin Ory, Françoise Rédini, Franck Verrecchia   +14 more
doaj   +7 more sources

Ubiquitin-Specific Proteases: Players in Cancer Cellular Processes

Pharmaceuticals, 2021
Ubiquitination represents a post-translational modification (PTM) essential for the maintenance of cellular homeostasis. Ubiquitination is involved in the regulation of protein function, localization and turnover through the attachment of a ubiquitin ...
Lucas Cruz, Paula Soares, Marcelo Correia   +2 more
doaj   +3 more sources

Spotlights on ubiquitin-specific proteases in lung cancer: from multifaceted pathophysiological mechanisms to potential therapeutic targets [PDF]

PeerJ
Lung cancer ranks as the leading cause of cancer-related mortality worldwide, characterised by complex molecular mechanisms and high therapeutic resistance.
Xiaoyun Shen, Ruoqi Wang, Fei Su, Juanjuan Guo, Da Zhao, Fangyun Yuan, Tao Zhang, Xiaoming Hou   +7 more
doaj   +3 more sources

Ubiquitin-Specific Protease 45 Inhibits Lung Adenocarcinoma Ferroptosis by Regulating Ubiquitination and Stability of Glutathione Peroxidase 4. [PDF]

Cancer Med
ABSTRACT Lung adenocarcinoma is the most common subtype of lung cancer and the leading cause of cancer‐related mortality worldwide. Ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation, has emerged as a promising therapeutic target for lung adenocarcinoma.
Huang M, Fang M, Wang Y, Liu S, Li F.
europepmc   +2 more sources

Identification and Validation of Ubiquitin-Specific Proteases as a Novel Prognostic Signature for Hepatocellular Carcinoma

Frontiers in Oncology, 2021
PurposeUbiquitin-specific proteases (USPs), as a sub-family of deubiquitinating enzymes (DUBs), are responsible for the elimination of ubiquitin-triggered modification. USPs are recently correlated with various malignancies.
Wenkai Ni, Wenkai Ni, Saiyan Bian, Saiyan Bian, Mengqi Zhu, Qianqian Song, Jianping Zhang, Mingbing Xiao, Wenjie Zheng   +8 more
doaj   +3 more sources

Broad-spectrum ubiquitin-specific protease inhibition as a mechanism for the cytotoxicity of YM155 in cancers [PDF]

Scientific Reports
Protein ubiquitination is a dynamic and reversible process involved in gene transcription, protein metabolism, and cellular apoptosis. Ubiquitin specific proteases (USPs), as the largest family of deubiquitinating enzymes, are able to remove the ...
Xiang Li, Na He, Yan Lv, Haiyue Wang, Ming Zhang, Heiyan Zhai, Zhen Yang, Yi Yang, Dagang Guo, Zhixiang Cao, Yiyou Chen   +10 more
doaj   +2 more sources