Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application [PDF]
Journal of Experimental and Clinical Cancer Research, 2023 Tumors have evolved in various mechanisms to evade the immune system, hindering the antitumor immune response and facilitating tumor progression. Immunotherapy has become a potential treatment strategy specific to different cancer types by utilizing ...
Jinqi Xue, Fei Xing, Jianqiao Yin
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Ubiquitin-specific proteases (USPs) in leukemia: a systematic review [PDF]
BMC CancerBackground Leukemia, a type of blood cell cancer, is categorized by the type of white blood cells affected (lymphocytes or myeloid cells) and disease progression (acute or chronic).
Zahra Salehi, Soheila Rahgozar
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Molecular Mechanisms of the Ubiquitin-Specific Proteases (USPs) Family in Biliary Tract Cancer and Targeted Intervention Strategies [PDF]
BiomedicinesBiliary tract carcinoma (BTC) is a group of highly heterogeneous malignancies arising from the biliary epithelium. Anatomically, BTC is categorized into gallbladder cancer (GBC) and cholangiocarcinoma (CCA), with the latter further subdivided into ...
Ma Delin, Qian Cheng
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Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders [PDF]
International Journal of Molecular Sciences, 2023 Ubiquitination and deubiquitination are reversible processes that modify the characteristics of target proteins, including stability, intracellular localization, and enzymatic activity. Ubiquitin-specific proteases (USPs) constitute the largest deubiquitinating enzyme family.
Hiroshi Kitamura
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Drug resistance mechanisms and treatment strategies mediated by Ubiquitin-Specific Proteases (USPs) in cancers: new directions and therapeutic options [PDF]
Molecular CancerDrug resistance represents a significant obstacle in cancer treatment, underscoring the need for the discovery of novel therapeutic targets. Ubiquitin-specific proteases (USPs), a subclass of deubiquitinating enzymes, play a pivotal role in protein ...
Zhuo Xi, Jinqi Xue
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Ubiquitin-Specific Proteases: Players in Cancer Cellular Processes [PDF]
Pharmaceuticals, 2021 Ubiquitination represents a post-translational modification (PTM) essential for the maintenance of cellular homeostasis. Ubiquitination is involved in the regulation of protein function, localization and turnover through the attachment of a ubiquitin ...
Paula Soares, Correia M
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Literature review: nuclear factor kappa B (NF-κB) regulation in human cancers mediated by ubiquitin-specific proteases (USPs) [PDF]
Annals of Translational MedicineThe nuclear factor kappa B (NF-κB) consists of a group of transcription factors of which its dysregulation is responsible for diseases such as inflammation and cancer. Ubiquitin-specific proteases (USPs) are the most prominent group among the deubiquitinases (DUBs).
Shen K, Zhang Q.
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Correction: Ubiquitin-specific proteases (USPs) in leukemia: a systematic review [PDF]
BMC CancerAlireza Zangooie +9 more
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Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects [PDF]
BiomoleculesCancer management has traditionally depended on chemotherapy as the mainstay of treatment; however, recent advancements in targeted therapies and immunotherapies have offered new options.
Dapeng Li +2 more
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Overexpression of the Ubiquitin Specific Proteases USP43, USP41, USP27x and USP6 in Osteosarcoma Cell Lines: Inhibition of Osteosarcoma Tumor Growth and Lung Metastasis Development by the USP Antagonist PR619 [PDF]
Cells, 2021 Osteosarcoma (OS) is the most common malignant bone tumor in children and teenagers. In many cases, such as poor response to treatment or the presence of metastases at diagnosis, the survival rate of patients remains very low. Although in the literature,
Mélanie Lavaud +14 more
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