Results 21 to 30 of about 7,309,904 (153)

Systematic discovery of motif-based interactions of the auxiliary domains of USP family deubiquitinases [PDF]

Nature Communications
The ubiquitin-specific proteases (USPs) family is the largest family of human deubiquitinating enzymes (DUBs). While most USPs are agnostic to polyubiquitin linkage-type, their substrate specificity is thought to be mediated by the recognition of the ...
Aimiliani Konstantinou, Alicia Córdova-Pérez, Julia K. Varga, Priyanka Madhu, Leandro Simonetti, Maximilian Vieler, Ryosuke Ishimura, Frederic Lamoliatte, Ora Schueler-Furman, Norman E. Davey, Yogesh Kulathu, Ylva Ivarsson   +11 more
doaj   +2 more sources

Broad-spectrum ubiquitin-specific protease inhibition as a mechanism for the cytotoxicity of YM155 in cancers [PDF]

Scientific Reports
Protein ubiquitination is a dynamic and reversible process involved in gene transcription, protein metabolism, and cellular apoptosis. Ubiquitin specific proteases (USPs), as the largest family of deubiquitinating enzymes, are able to remove the ...
Xiang Li, Na He, Yan Lv, Haiyue Wang, Ming Zhang, Heiyan Zhai, Zhen Yang, Yi Yang, Dagang Guo, Zhixiang Cao, Yiyou Chen   +10 more
doaj   +2 more sources

USP52 promotes clear cell renal carcinoma progression by deubiquitinating and stabilizing CORO6 [PDF]

Translational Oncology
Clear cell renal carcinoma (ccRCC) is the most common type of kidney cancer. CORO6 functions as an oncogene in various malignancies, including ccRCC, but the mechanisms regulating its expression, particularly at the post-translational level, remain ...
Xinjun Wang, Nangen Zhang, Yue Bu, Ying Zhang, Xuqiang Wang, Xianfa He, Xi Zhuang, Qian Zong, Bin Zhou, Guangcheng Luo   +9 more
doaj   +2 more sources

Ubiquitin-specific protease 11 suppresses cuproptosis in colorectal cancer by regulating the ubiquitination and stability of ISCU [PDF]

Oncogenesis
Colorectal cancer (CRC) remains one of the most common and deadly malignancies, with limited effective treatment options. Cuproptosis is a novel regulated cell death triggered by mitochondrial copper overload (Cu2+) and has been implicated in several ...
Hailin Ke, Guowei Zhang, Weili Lin, Yuecui Jiang, Meina Wu, Yueyi Zhang, Weiyang Song, Fuhai Wang, Songling Yan   +8 more
doaj   +2 more sources

USP48 functions as a suppressor of colorectal cancer via SELENBP1 stabilization [PDF]

Translational Oncology
Aim: Colorectal cancer (CRC) is a leading cause of cancer-related death. SELENBP1 is a tumor suppressor in CRC. However, the mechanism regulating the stability of the SELENBP1 protein remains elusive.
Hongyue Lin, Ying Huang
doaj   +2 more sources

Ubiquitin-specific proteases in hepatitis: bridging molecular mechanisms and therapeutic potential

Egyptian Liver Journal
Hepatitis is a significant cause of severe liver diseases, including cirrhosis, liver failure, and hepatocellular carcinoma. Current strategies include antiviral drugs, vaccination, and liver transplantation; however, a potential therapeutic strategy is ...
Ashok Kumar Bishoyi, Muhammad Afzal, Ashish Singh Chauhan   +2 more
exaly   +2 more sources

Ubiquitin-specific protease 34 serves as a novel prognostic biomarker through correlating with immune responses and cell proliferation in acute myeloid leukemia [PDF]

Discover Oncology
Background Emerging evidence showed that ubiquitin-specific proteases (USPs) are promising therapeutic targets for hematopoietic malignancies. The roles of USP34 on acute myeloid leukemia (AML) pathogenesis remain completely unknown.
Zhihui Li, Cuijuan Shi
doaj   +2 more sources

Ubiquitin specific peptidases and prostate cancer [PDF]

PeerJ, 2023
Protein ubiquitination is an important post-translational modification mechanism, which regulates protein stability and activity. The ubiquitination of proteins can be reversed by deubiquitinating enzymes (DUBs).
Yunfei Guo, Shuaishuai Cui, Yuanyuan Chen, Song Guo, Dahu Chen   +4 more
doaj   +2 more sources

Genome-wide identification and characterization of the ubiquitin-specific protease (USP) gene family in cattle: primary analysis of muscle-specific USP genes and their influence on myogenesis. [PDF]

BMC Genomics
Zan Y, Li J, Song F, Tang Y, Xin Y, Zhang Z, Wang L, Zhang L, Du L, Yuan Z, Gao X.   +10 more
europepmc   +3 more sources

Research progress on ubiquitin-specific proteases in regulation of bone remodeling

口腔疾病防治, 2022
Maintaining bone homeostasis relies on the balance between bone remodeling involving bone resorption by osteoclasts and bone formation by osteoblasts under physiological conditions. An increasing number of studies have shown that the ubiquitin-proteasome
ZHANG Guorui, WU Yingying, XIONG Yi
doaj   +1 more source