Results 21 to 30 of about 1,825 (127)

USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF [PDF]

Advanced Science
Melanoma, a highly malignant skin cancer, has seen a rising incidence and death toll. MRGPRF is a novel melanoma suppressor that inhibits the PI3K/AKT pathway. However, the regulation of MRGPRF in melanoma remains unclear.
Wancong Zhang, Liyun Chen, Jing Zhao, Aiwei Ma, Wenqi Shi, Yiwen Zhang, Zixuan Tang, Jiarui Guo, Zaihua Xu, Jianda Zhou, Shijie Tang   +10 more
doaj   +2 more sources

Ubiquitin specific peptidases and prostate cancer [PDF]

PeerJ, 2023
Protein ubiquitination is an important post-translational modification mechanism, which regulates protein stability and activity. The ubiquitination of proteins can be reversed by deubiquitinating enzymes (DUBs).
Yunfei Guo, Shuaishuai Cui, Yuanyuan Chen, Song Guo, Dahu Chen   +4 more
doaj   +2 more sources

Hypermethylated USP44 deubiquitinates SENP2: a critical mechanism in esophageal cancer progression and a new target for intervention [PDF]

Clinical Epigenetics
Background Ubiquitin-specific proteases (USPs) play a critical role in the development of various cancers. The study aimed to elucidated the pathogenic molecular mechanisms and analyze its clinical significance in esophageal squamous cell carcinoma (ESCC)
Haibo Wu, Xinke Zhang, Zhengyi Zhou, Keming Chen, Jierong Chen, Chao Ma, Jinling Duan, Yingqing Li, Jiewei Chen   +8 more
doaj   +2 more sources

Genome-wide identification and characterization of the ubiquitin-specific protease (USP) gene family in cattle: primary analysis of muscle-specific USP genes and their influence on myogenesis. [PDF]

BMC Genomics
Zan Y, Li J, Song F, Tang Y, Xin Y, Zhang Z, Wang L, Zhang L, Du L, Yuan Z, Gao X.   +10 more
europepmc   +3 more sources

Research progress on ubiquitin-specific proteases in regulation of bone remodeling

口腔疾病防治, 2022
Maintaining bone homeostasis relies on the balance between bone remodeling involving bone resorption by osteoclasts and bone formation by osteoblasts under physiological conditions. An increasing number of studies have shown that the ubiquitin-proteasome
ZHANG Guorui, WU Yingying, XIONG Yi
doaj   +1 more source

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells [PDF]

Proceedings of the National Academy of Sciences, 2004
The family of ubiquitin (Ub)-specific proteases (USP) removes Ub from Ub conjugates and regulates a variety of cellular processes. The human genome contains many putative USP-encoding genes, but little is known about USP tissue distribution, pattern of expression, activity, and substrate specificity. We have used a chemistry-based functional proteomics
Ovaa, H, Kessler, B, Rolén, U, Galardy, P, Ploegh, H, Masucci, MG   +5 more
openaire   +3 more sources

A risk signature of ubiquitin-specific protease family predict the prognosis and therapy of kidney cancer patients

BMC Nephrology, 2023
Ubiquitin-specific proteases (USPs) are closely related to protein fate and cellular processes through various molecular signalling pathways, including DNA damage repair, p53, and transforming growth factor-β (TGF-β) pathways. In recent years, increasing
Renjie Wang, Yang Liu, Jingxian Li, Yubao Zhao, Rui An, Zhifang Ma   +5 more
doaj   +1 more source

Targeted therapy based on ubiquitin-specific proteases, signalling pathways and E3 ligases in non-small-cell lung cancer

Frontiers in Oncology, 2023
Lung cancer is one of the most common malignant tumours worldwide, with the highest mortality rate. Approximately 1.6 million deaths owing to lung cancer are reported annually; of which, 85% of deaths occur owing to non-small-cell lung cancer (NSCLC). At
Yu-Chen Yang, Can-Jun Zhao, Zhao-Feng Jin, Jin Zheng, Li-Tian Ma, Li-Tian Ma   +5 more
doaj   +1 more source

Gene Signature and Prognostic Value of Ubiquitin-Specific Proteases Members in Hepatocellular Carcinoma and Explored the Immunological Role of USP36

Frontiers in Bioscience-Landmark, 2022
Background: Ubiquitination is one of the most common post-translational modifications in cells and dysregulation is closely associated with the development of cancer.
Weijie Sun, Jiapei Shen, Jiaying Liu, Kexing Han, Leilei Liang, Yufeng Gao   +5 more
doaj   +1 more source

Role of ubiquitin specific proteases in the immune microenvironment of prostate cancer: A new direction

Frontiers in Oncology, 2022
Regulation of ubiquitination is associated with multiple processes of tumorigenesis and development, including regulation of the tumor immune microenvironment.
Jinhui Guo, Jinhui Guo, Jie Zhao, Litao Sun, Chen Yang   +4 more
doaj   +1 more source