Results 11 to 20 of about 7,309,904 (153)

Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation [PDF]

World Journal of Surgical Oncology
Breast cancer is a prevalent malignancy worldwide, and its treatment has increasingly shifted towards precision medicine, with immunotherapy emerging as a key therapeutic strategy.
Huiyuan Yang, Tingting Sun, Zhenni Sun, Haining Wang, Dongjie Liu, Dapeng Wu, Tao Qin, Mi Zhou   +7 more
doaj   +3 more sources

Regulation of neuronal morphogenesis and positioning by ubiquitin-specific proteases in the cerebellum. [PDF]

PLoS ONE, 2015
Ubiquitin signaling mechanisms play fundamental roles in the cell-intrinsic control of neuronal morphogenesis and connectivity in the brain. However, whereas specific ubiquitin ligases have been implicated in key steps of neural circuit assembly, the ...
Julius Anckar, Azad Bonni
doaj   +3 more sources

Spotlights on ubiquitin-specific proteases in lung cancer: from multifaceted pathophysiological mechanisms to potential therapeutic targets [PDF]

PeerJ
Lung cancer ranks as the leading cause of cancer-related mortality worldwide, characterised by complex molecular mechanisms and high therapeutic resistance.
Xiaoyun Shen, Ruoqi Wang, Fei Su, Juanjuan Guo, Da Zhao, Fangyun Yuan, Tao Zhang, Xiaoming Hou   +7 more
doaj   +3 more sources

Role of ubiquitin specific proteases in the immune microenvironment of prostate cancer: A new direction [PDF]

Frontiers in Oncology, 2022
Regulation of ubiquitination is associated with multiple processes of tumorigenesis and development, including regulation of the tumor immune microenvironment.
Jinhui Guo, Jinhui Guo, Jie Zhao, Litao Sun, Chen Yang   +4 more
doaj   +2 more sources

Gene Signature and Prognostic Value of Ubiquitin-Specific Proteases Members in Hepatocellular Carcinoma and Explored the Immunological Role of USP36

Frontiers in Bioscience, 2022
Background: Ubiquitination is one of the most common post-translational modifications in cells and dysregulation is closely associated with the development of cancer.
Leilei Liang, Weijie Sun, Yufeng Gao
exaly   +3 more sources

Ubiquitin-specific proteases are differentially expressed throughout the Schistosoma mansoni life cycle

Parasites & Vectors, 2015
Background The ubiquitination process can be reversed by deubiquitinating enzymes (DUBs). These proteases are involved in ubiquitin processing, in the recovery of modified ubiquitin trapped in inactive forms, and in the recycling of ubiquitin monomers ...
Roberta V. Pereira, Matheus de S Gomes, Roenick P. Olmo, Daniel M. Souza, Fernanda J. Cabral, Liana K. Jannotti-Passos, Elio H. Baba, Andressa B. P. Andreolli, Vanderlei Rodrigues, William Castro-Borges, Renata Guerra-Sá   +10 more
doaj   +2 more sources

Inhibition of Ubiquitin-Specific Proteases as a Novel Anticancer Therapeutic Strategy [PDF]

Frontiers in Pharmacology, 2018
Dysfunction or dysregulation of the ubiquitin proteasome system (UPS) is closely related to tumorigenesis and the development of multiple cancers. Targeting the UPS provides a new anticancer therapeutic strategy, but clinically available UPS-targeted ...
Tao Yuan, Fangjie Yan, Meidan Ying, Ji Cao, Qiaojun He, Hong Zhu, Bo Yang   +6 more
doaj   +2 more sources

Ubiquitin-specific proteases in ovarian cancer: molecular mechanisms and therapeutic implications [PDF]

Journal of Ovarian Research
Ovarian cancer (OC) remains one of the most lethal gynecological malignancies, largely due to late-stage diagnosis, frequent recurrence, and the development of resistance to standard therapies.
Lu Deng, Yuzhao Jiang, Danning Wang, Jing Yu, Lingying Wu   +4 more
doaj   +2 more sources

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease. [PDF]

Adv Sci (Weinh)
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Li L, Tang H, Yu Q, Zhang Y, Shi B, Kong Y, Xu L, Shao J, Hu C, She L, Wang Z, Chen H, Samorodov AV, Cao G, Zhao X, Wang Y.   +15 more
europepmc   +2 more sources

USP48 promotes tumour progression through the deubiquitination and stabilization of DBF4 in clear cell renal carcinoma [PDF]

Cancer Cell International
Background The upregulation of DBF4 is correlated with a poor prognosis in patients with clear cell renal cell carcinoma (ccRCC), yet the mechanisms governing the expression and protein stability of DBF4 remain unknown. Ubiquitin-specific proteases (USPs)
Lingfeng Zhu, Liuyan Chen, Lvying Wu, Na Lin, Wenyi Deng, Kuanyin Wang, Yaoyao Liang, Jianan Zhang, Jin Chen   +8 more
doaj   +2 more sources