Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders [PDF]
International Journal of Molecular Sciences, 2023 Ubiquitination and deubiquitination are reversible processes that modify the characteristics of target proteins, including stability, intracellular localization, and enzymatic activity. Ubiquitin-specific proteases (USPs) constitute the largest deubiquitinating enzyme family.
Hiroshi Kitamura, Kitamura Hiroshi
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Correction: Ubiquitin-specific proteases (USPs) in leukemia: a systematic review [PDF]
BMC CancerAlireza Zangooie +9 more
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Literature review: nuclear factor kappa B (NF-κB) regulation in human cancers mediated by ubiquitin-specific proteases (USPs) [PDF]
Annals of Translational MedicineThe nuclear factor kappa B (NF-κB) consists of a group of transcription factors of which its dysregulation is responsible for diseases such as inflammation and cancer. Ubiquitin-specific proteases (USPs) are the most prominent group among the deubiquitinases (DUBs).
Shen K, Zhang Q.
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USP52 promotes clear cell renal carcinoma progression by deubiquitinating and stabilizing CORO6 [PDF]
Translational OncologyClear cell renal carcinoma (ccRCC) is the most common type of kidney cancer. CORO6 functions as an oncogene in various malignancies, including ccRCC, but the mechanisms regulating its expression, particularly at the post-translational level, remain ...
Xinjun Wang +9 more
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Roles of ubiquitin-specific proteases in inflammatory diseases
Frontiers in ImmunologyUbiquitin-specific proteases (USPs), as one of the deubiquitinating enzymes (DUBs) families, regulate the fate of proteins and signaling pathway transduction by removing ubiquitin chains from the target proteins.
Rui Chen +18 more
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Inhibition of Ubiquitin-Specific Proteases as a Novel Anticancer Therapeutic Strategy
Frontiers in Pharmacology, 2018 Dysfunction or dysregulation of the ubiquitin proteasome system (UPS) is closely related to tumorigenesis and the development of multiple cancers. Targeting the UPS provides a new anticancer therapeutic strategy, but clinically available UPS-targeted ...
Tao Yuan +6 more
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Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation [PDF]
World Journal of Surgical OncologyBreast cancer is a prevalent malignancy worldwide, and its treatment has increasingly shifted towards precision medicine, with immunotherapy emerging as a key therapeutic strategy.
Huiyuan Yang +7 more
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Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects [PDF]
BiomoleculesCancer management has traditionally depended on chemotherapy as the mainstay of treatment; however, recent advancements in targeted therapies and immunotherapies have offered new options.
Mohamad Bakkar +9 more
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Ubiquitin-specific protease 34 serves as a novel prognostic biomarker through correlating with immune responses and cell proliferation in acute myeloid leukemia [PDF]
Discover OncologyBackground Emerging evidence showed that ubiquitin-specific proteases (USPs) are promising therapeutic targets for hematopoietic malignancies. The roles of USP34 on acute myeloid leukemia (AML) pathogenesis remain completely unknown.
Zhihui Li, Cuijuan Shi
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Pharmacological ResearchCancer represents a significant global health threat, with the World Health Organization reporting millions of new cases annually. Dysregulation in cellular homestasis leads to the aggressive and heterogeneous nature of cancers.
Yongqing Xu +7 more
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