Results 31 to 40 of about 7,309,904 (153)

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells [PDF]

Proceedings of the National Academy of Sciences, 2004
The family of ubiquitin (Ub)-specific proteases (USP) removes Ub from Ub conjugates and regulates a variety of cellular processes. The human genome contains many putative USP-encoding genes, but little is known about USP tissue distribution, pattern of expression, activity, and substrate specificity. We have used a chemistry-based functional proteomics
Ovaa, H, Kessler, B, Rolén, U, Galardy, P, Ploegh, H, Masucci, MG   +5 more
openaire   +3 more sources

A risk signature of ubiquitin-specific protease family predict the prognosis and therapy of kidney cancer patients

BMC Nephrology, 2023
Ubiquitin-specific proteases (USPs) are closely related to protein fate and cellular processes through various molecular signalling pathways, including DNA damage repair, p53, and transforming growth factor-β (TGF-β) pathways. In recent years, increasing
Renjie Wang, Yang Liu, Jingxian Li, Yubao Zhao, Rui An, Zhifang Ma   +5 more
doaj   +1 more source

Targeted therapy based on ubiquitin-specific proteases, signalling pathways and E3 ligases in non-small-cell lung cancer

Frontiers in Oncology, 2023
Lung cancer is one of the most common malignant tumours worldwide, with the highest mortality rate. Approximately 1.6 million deaths owing to lung cancer are reported annually; of which, 85% of deaths occur owing to non-small-cell lung cancer (NSCLC). At
Yu-Chen Yang, Can-Jun Zhao, Zhao-Feng Jin, Jin Zheng, Li-Tian Ma, Li-Tian Ma   +5 more
doaj   +1 more source

Divergent ubiquitin interactions among ubiquitin specific proteases and development of small molecule DUB inhibitors

, 2022
Zhuang, ZhihaoDeubiquitinating enzymes (DUBs) are responsible for reversing mono- and poly-ubiquitination of proteins and play essential roles in numerous cellular processes.
Tencer, Adam
core   +1 more source

Ubiquitin‐specific protease 7 (USP7) is essential for endometrial stromal cell decidualization in mice [PDF]

Development, Growth & Differentiation, 2019
Ubiquitin‐specific protease 7 (USP7), a member of the deubiquitinating (DUB) enzyme family, regulates protein stability and has a well‐characterized function in tumorigenesis. Given its critical role in growth and development, it was speculated to be involved in modulating processes in the female reproductive system but its exact role has not been ...
Yue Gao, Yaqin Wang, Chan Zhou, Shuangbo Kong, Jinhua Lu, Haibin Wang, Jing Yang   +6 more
openaire   +2 more sources

A Plasmodium falciparum ubiquitin-specific protease (PfUSP) is essential for parasite survival and its disruption enhances artemisinin efficacy

Biochemical Journal, 2023
Proteins associated with ubiquitin–proteasome system (UPS) are potential drug targets in the malaria parasite. The ubiquitination and deubiquitination are key regulatory processes for the functioning of UPS. In this study, we have characterized the biochemical and functional role of a novel ubiquitin-specific protease (USP) domain-containing protein of
Priya Arora, Monika Narwal, Vandana Thakur, Osama Mukhtar, Pawan Malhotra, Asif Mohmmed   +5 more
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Structural basis for the SUMO protease activity of the atypical ubiquitin-specific protease USPL1 [PDF]

, 2022
Post-translational protein modifications by ubiquitin and ubiquitin-like modifiers regulate many major pathways in the cell. These modifications can be reversed by de-ubiquitinating enzymes such as ubiquitin-specific proteases (USPs).
Li, Ying, Reverter i Cendrós, David, Varejão, Nathalia   +2 more
core   +1 more source

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry [PDF]

, 2014
Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive
Virdee, Satpal; id_orcid, Gray, Nathanael, Trost, Matthias, Ritorto, Maria Stella, Gray, Nathanael S., Alessi, Dario R., Perez-Oliva, Ana B., Wood, Nicola T., Alessi, Dario R.; id_orcid, Knebel, Axel, Buhrlage, Sara J., Ewan, Richard, Wightman, Melanie, Morrice, Nicholas A., Virdee, Satpal, Kelly, Sharon M.   +15 more
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Identification and Validation of Ubiquitin-Specific Proteases as a Novel Prognostic Signature for Hepatocellular Carcinoma

Frontiers in Oncology, 2021
PurposeUbiquitin-specific proteases (USPs), as a sub-family of deubiquitinating enzymes (DUBs), are responsible for the elimination of ubiquitin-triggered modification. USPs are recently correlated with various malignancies.
Wenkai Ni, Wenkai Ni, Saiyan Bian, Saiyan Bian, Mengqi Zhu, Qianqian Song, Jianping Zhang, Mingbing Xiao, Wenjie Zheng   +8 more
doaj   +1 more source

An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19

Biochemical and Biophysical Research Communications, 2013
The Ubiquitin Specific Protease-19 (USP19) regulates cell cycle progression and is involved in the cellular response to different types of stress, including the unfolded protein response (UPR), hypoxia and muscle atrophy. Using the unique N-terminal domain as bait in a yeast-two hybrid screen we have identified the ubiquitin ligases Seven In Absentia ...
Velasco K, Zhao B, Callegari S, Altun M, Liu H, Hassink G, Masucci MG, Lindsten K   +7 more
openaire   +3 more sources