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Advances in the Development Ubiquitin-Specific Peptidase (USP) Inhibitors [PDF]
International Journal of Molecular Sciences, 2021 Ubiquitylation and deubiquitylation are reversible protein post-translational modification (PTM) processes involving the regulation of protein degradation under physiological conditions. Loss of balance in this regulatory system can lead to a wide range of diseases, such as cancer and inflammation.
Shiyao Chen, Yunqi Liu, Huchen Zhou
europepmc +6 more sources
Ubiquitin-specific proteases in ovarian cancer: molecular mechanisms and therapeutic implications [PDF]
Journal of Ovarian ResearchOvarian cancer (OC) remains one of the most lethal gynecological malignancies, largely due to late-stage diagnosis, frequent recurrence, and the development of resistance to standard therapies.
Lu Deng +4 more
doaj +2 more sources
Ubiquitin-specific proteases as key regulators in the malignant progression and therapy resistance of colorectal cancer: current insights and future perspectives [PDF]
Discover OncologyAs a member of the DUBs (deubiquitinating enzymes) family, USPs (ubiquitin-specific peptidases) play a crucial regulatory role in the occurrence and progression of various malignancies.
Junyan Li +9 more
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Spotlights on ubiquitin-specific proteases in lung cancer: from multifaceted pathophysiological mechanisms to potential therapeutic targets [PDF]
PeerJLung cancer ranks as the leading cause of cancer-related mortality worldwide, characterised by complex molecular mechanisms and high therapeutic resistance.
Xiaoyun Shen +7 more
doaj +3 more sources
Molecular Mechanisms of the Ubiquitin-Specific Proteases (USPs) Family in Biliary Tract Cancer and Targeted Intervention Strategies [PDF]
BiomedicinesBiliary tract carcinoma (BTC) is a group of highly heterogeneous malignancies arising from the biliary epithelium. Anatomically, BTC is categorized into gallbladder cancer (GBC) and cholangiocarcinoma (CCA), with the latter further subdivided into ...
Qian Cheng +6 more
doaj +2 more sources
Drug Analytical Research, 2018 This study describes two analytical methods, by second-order derivative UV spectrophotometric by HPLC, for determination of vildagliptin, a drug used for treatment of type 2 Diabetes Mellitus that belongs to a therapeutic class called inhibitors of ...
Amanda Thomas Barden +3 more
doaj +9 more sources
Journal of Neurochemistry, 2017 AbstractStroke is associated with over‐production of misfolded and aggregating proteins. However, it remains largely unclear whether enhanced removal of protein aggregates following ischemic stroke is neuroprotective. Deubiquitinating enzymes (DUBs) are a large group of proteases that regulate protein degradation.
Jia-Wei, Min +4 more
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Journal of Experimental & Clinical Cancer Research, 2023 Tumors have evolved in various mechanisms to evade the immune system, hindering the antitumor immune response and facilitating tumor progression. Immunotherapy has become a potential treatment strategy specific to different cancer types by utilizing ...
Hongli Gao +8 more
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Biochemical and Biophysical Research Communications, 2020 The tumor suppressor CYLD negatively regulates polyubiquitination-dependent cellular signaling such as nuclear factor (NF)-κB signaling. In addition to CYLD, multiple deubiquitinating enzymes (DUBs) are also involved in the regulation of this signaling pathway, and distinct role of CYLD is yet to be clarified. Here, we identified a small chemical named
Satoshi Yamanaka +7 more
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Ubiquitin-Specific Proteases: Players in Cancer Cellular Processes
Pharmaceuticals, 2021 Ubiquitination represents a post-translational modification (PTM) essential for the maintenance of cellular homeostasis. Ubiquitination is involved in the regulation of protein function, localization and turnover through the attachment of a ubiquitin ...
Lucas Cruz +2 more
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