Advances in the Development Ubiquitin-Specific Peptidase (USP) Inhibitors [PDF]
International Journal of Molecular Sciences, 2021 Ubiquitylation and deubiquitylation are reversible protein post-translational modification (PTM) processes involving the regulation of protein degradation under physiological conditions. Loss of balance in this regulatory system can lead to a wide range of diseases, such as cancer and inflammation.
Huchen Zhou, Shiyao Chen
exaly +4 more sources
Ubiquitin-specific proteases as key regulators in the malignant progression and therapy resistance of colorectal cancer: current insights and future perspectives [PDF]
Discover OncologyAs a member of the DUBs (deubiquitinating enzymes) family, USPs (ubiquitin-specific peptidases) play a crucial regulatory role in the occurrence and progression of various malignancies.
Junyan Li +9 more
doaj +2 more sources
Spotlights on ubiquitin-specific proteases in lung cancer: from multifaceted pathophysiological mechanisms to potential therapeutic targets [PDF]
PeerJLung cancer ranks as the leading cause of cancer-related mortality worldwide, characterised by complex molecular mechanisms and high therapeutic resistance.
Xiaoyun Shen +7 more
doaj +3 more sources
Molecular Mechanisms of the Ubiquitin-Specific Proteases (USPs) Family in Biliary Tract Cancer and Targeted Intervention Strategies [PDF]
BiomedicinesBiliary tract carcinoma (BTC) is a group of highly heterogeneous malignancies arising from the biliary epithelium. Anatomically, BTC is categorized into gallbladder cancer (GBC) and cholangiocarcinoma (CCA), with the latter further subdivided into ...
Qian Cheng +6 more
doaj +2 more sources
Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects [PDF]
BiomoleculesCancer management has traditionally depended on chemotherapy as the mainstay of treatment; however, recent advancements in targeted therapies and immunotherapies have offered new options.
Mohamad Bakkar +9 more
doaj +2 more sources
Global analysis of cancer cell responses to USP9X inhibition [PDF]
The EMBO JournalThe ubiquitin-specific protease (USP) USP9X is a human deubiquitinase (DUB) with a large number of described targets and cellular roles. In cancer, USP9X is found as an oncogene or as a tumour suppressor depending on context, and its utility as a target ...
Philipp Schenk +18 more
doaj +2 more sources
The deubiquitinase USP35: from an oncogenic hub to a therapeutic target in human cancers [PDF]
Frontiers in OncologyUbiquitination is a critical post-translational modification in eukaryotic cells, mediated by a sequential enzymatic cascade involving E1 (activating), E2 (conjugating), and E3 (ligase) enzymes that catalyze the covalent conjugation of ubiquitin to ...
Bisheng Li +6 more
doaj +2 more sources
Drug Analytical Research, 2018 This study describes two analytical methods, by second-order derivative UV spectrophotometric by HPLC, for determination of vildagliptin, a drug used for treatment of type 2 Diabetes Mellitus that belongs to a therapeutic class called inhibitors of ...
Amanda Thomas Barden +3 more
doaj +9 more sources
Journal of Neurochemistry, 2017 AbstractStroke is associated with over‐production of misfolded and aggregating proteins. However, it remains largely unclear whether enhanced removal of protein aggregates following ischemic stroke is neuroprotective. Deubiquitinating enzymes (DUBs) are a large group of proteases that regulate protein degradation.
Jia-Wei, Min +4 more
openaire +2 more sources
Journal of Experimental & Clinical Cancer Research, 2023 Tumors have evolved in various mechanisms to evade the immune system, hindering the antitumor immune response and facilitating tumor progression. Immunotherapy has become a potential treatment strategy specific to different cancer types by utilizing ...
Hongli Gao +8 more
doaj +1 more source