Results 21 to 30 of about 984,321 (234)

The role of ubiquitin-specific peptidases in cancer progression

Journal of Biomedical Science, 2019
Protein ubiquitination is an important mechanism for regulating the activity and levels of proteins under physiological conditions. Loss of regulation by protein ubiquitination leads to various diseases, such as cancer.
Ming-Jer Young, Kai-Cheng Hsu, Tony Eight Lin, Wen-Chang Chang, Jan-Jong Hung   +4 more
doaj   +1 more source

Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects

Biomolecules
Cancer management has traditionally depended on chemotherapy as the mainstay of treatment; however, recent advancements in targeted therapies and immunotherapies have offered new options.
Mohamad Bakkar, Sara Khalil, Komal Bhayekar, Narva Deshwar Kushwaha, Amirreza Samarbakhsh, Sadaf Dorandish, Holly Edwards, Q. Ping Dou, Yubin Ge, Navnath S. Gavande   +9 more
doaj   +1 more source

Screen for ISG15-crossreactive deubiquitinases. [PDF]

PLoS ONE, 2007
The family of ubiquitin-like molecules (UbLs) comprises several members, each of which has sequence, structural, or functional similarity to ubiquitin. ISG15 is a homolog of ubiquitin in vertebrates and is strongly upregulated following induction by type
André Catic, Edda Fiebiger, Gregory A Korbel, Daniël Blom, Paul J Galardy, Hidde L Ploegh   +5 more
doaj   +1 more source

Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters

Biomolecules, 2023
The aim of this work is to verify the possibility of transport of 26 biologically active ultrashort peptides (USPs) into cells via LAT and PEPT family transporters.
Vladimir Khatskelevich Khavinson, Natalia Sergeevna Linkova, Andrey Ivanovich Rudskoy, Michael Gennadievich Petukhov   +3 more
doaj   +1 more source

Research Progress of DUB Enzyme in Hepatocellular Carcinoma

Frontiers in Oncology, 2022
According to GLOBOCAN 2021 cancer incidence and mortality statistics compiled by the International Agency for Research on Cancer, hepatocellular carcinoma (HCC) is the most common malignancy in the human liver and one of the leading causes of cancer ...
Jie Zhao, Jie Zhao, Jinhui Guo, Yanan Wang, Qiancheng Ma, Yu Shi, Feng Cheng, Qiliang Lu, Wen Fu, Guangxiong Ouyang, Ji Zhang, Qiuran Xu, Xiaoge Hu, Xiaoge Hu   +13 more
doaj   +1 more source

USP39: a key regulator in malignant tumor progression

Frontiers in Oncology
Ubiquitin-specific protease 39 (USP39), a member of the USP family, plays a unique role beyond classical deubiquitination by interacting with target molecules and regulating their pre-mRNA splicing, which enhances its functional specificity compared to ...
Junyan Li, Jinghua Zhong, Jinghua Zhong, Jianming Ye, Jianming Ye, Yi Xiang, Yi Xiang, Xiangcai Wang, Xiangcai Wang   +8 more
doaj   +1 more source

Naringenin derivatives as glucosamine-6-phosphate synthase inhibitors: synthesis, antioxidants, antimicrobial, preservative efficacy, molecular docking and in silico ADMET analysis

BMC Chemistry, 2020
Background Preservatives have to be added in food, pharmaceuticals and cosmetics products to maintain their shelf life. However, the existing chemical based preservatives have been associated with severe side effects that compel the researchers to find ...
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source

NATURAL KILLER CELLS PHENOTYPE CORRELATES WITH TYROSINE KINASE INHIBITORS TREATMENT RESPONSE IN CHRONIC MYELOID LEUKEMIA PATIENTS

Hematology, Transfusion and Cell Therapy, 2021
Background: Despite well-known Natural Killer (NK) cells antitumor activity, its potential in regulating Chronic Myeloid Leukemia (CML) is not fully stablished.
LS Binelli, AFO Costa, LO Marani, IA Lopes, F Traina, LC Palma, PMM Garibaldi, LL Figueiredo-Pontes   +7 more
doaj   +1 more source

In Vivo Monitoring of Thrombo‐Inflammatory Biomarkers via Molecularly Imprinted Polymer‐Integrated Hydrogel Microneedles

Advanced Materials, EarlyView.
A wearable electrochemical microneedle patch integrates Prussian Blue redox transduction with molecularly imprinted polymer recognition for reagent‐free sampling and detection of thrombo‐inflammatory biomarkers in dermal interstitial fluid. The platform tracks thrombin and inflammatory cytokines with sensitive in vitro, ex vivo, and in vivo performance,
Mahmoud Ayman Saleh, Peyman GhavamiNejad, Arash Khorrami Jahromi, Sanjana Srikant, Sripadh Guptha Yedire, Fatemeh Keyvani, Roozbeh Siavash Moakhar, Sajad Shiekh, Mackenzie Graham, Joe Quadrilatero, Mahla Poudineh, Sara Mahshid   +11 more
wiley   +1 more source

Advances in Research on Ubiquitin Modification and Deubiquitinating Enzymes in Cancer Therapy [PDF]

BIO Web of Conferences
Ubiquitination, as a classic protein post-translational modification, plays a key role in maintaining protein homeostasis. Protein ubiquitination is a constantly changing and reversible process.
Liu Zhangrui
doaj   +1 more source