Results 11 to 20 of about 9,578 (166)

Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling

Biochemical and Biophysical Research Communications, 2020
The tumor suppressor CYLD negatively regulates polyubiquitination-dependent cellular signaling such as nuclear factor (NF)-κB signaling. In addition to CYLD, multiple deubiquitinating enzymes (DUBs) are also involved in the regulation of this signaling pathway, and distinct role of CYLD is yet to be clarified. Here, we identified a small chemical named
Satoshi Yamanaka, Yusuke Sato, Daisuke Oikawa, Eiji Goto, Shuya Fukai, Fuminori Tokunaga, Hirotaka Takahashi, Tatsuya Sawasaki   +7 more
openaire   +2 more sources

Ubiquitin-Specific Proteases: Players in Cancer Cellular Processes

Pharmaceuticals, 2021
Ubiquitination represents a post-translational modification (PTM) essential for the maintenance of cellular homeostasis. Ubiquitination is involved in the regulation of protein function, localization and turnover through the attachment of a ubiquitin ...
Lucas Cruz, Paula Soares, Marcelo Correia   +2 more
doaj   +1 more source

Binding of Vialinin A and p-Terphenyl Derivatives to Ubiquitin-Specific Protease 4 (USP4): A Molecular Docking Study

Molecules, 2022
The para-terphenyl derivative vialinin A (Vi-A), isolated from Thelephora fungi, has been characterized as a potent inhibitor of the ubiquitin-specific protease 4 (USP4).
Christian Bailly, Gérard Vergoten
doaj   +1 more source

Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening

Molecules, 2019
Leishmaniasis is a neglected disease that is caused by different species of the protozoan parasite Leishmania, and it currently affects 12 million people worldwide.
Ohm Prakash, Jana Führing, John Post, Sharon M. Shepherd, Thomas C. Eadsforth, David Gray, Roman Fedorov, Françoise H. Routier   +7 more
doaj   +1 more source

USP30: Structure, Emerging Physiological Role, and Target Inhibition

Frontiers in Pharmacology, 2022
Ubiquitin-specific protease 30 (USP30) is a deubiquitinating enzyme (DUB) belonging to the USP subfamily, which was found localized in the mitochondrial outer membrane and peroxisomes owing to its unique transmembrane domain.
Feng Wang, Yu Gao, Lihui Zhou, Junhao Chen, Zhiyan Xie, Zifan Ye, Yanfeng Wang   +6 more
doaj   +1 more source

Novel trends in fermented dairy technology [PDF]

Zbornik Matice Srpske za Prirodne Nauke, 2019
Novel trends in fermented dairy technology are presented in this review paper. The application of new starter cultures (probiotics, kombucha), as well as quality improving ingredients like transglutaminase (TGase), milk protein fractions, and ...
Carić Marijana Đ., Milanović Spasenija D., Iličić Mirela D.   +2 more
doaj   +1 more source

Recent Understanding and Future Directions of Recurrent Corticotroph Tumors

Frontiers in Endocrinology, 2021
Corticotroph tumors (CTs) are pituitary neoplasms arising from the Tpit lineage, which may or not express adrenocorticotrophic hormone (ACTH). Functioning CTs cause Cushing’s disease (CD), which has high morbidity and mortality due to hypercortisolemia. “
José Miguel Hinojosa-Amaya, César Ernesto Lam-Chung, Daniel Cuevas-Ramos   +2 more
doaj   +1 more source

Aesculin based glucosamine-6-phosphate synthase inhibitors as novel preservatives for food and pharmaceutical products: in-silico studies, antioxidant, antimicrobial and preservative efficacy evaluation

BMC Chemistry, 2021
Background Presently available chemical based synthetic preservative have emerged with various side effects, so the aspiration of natural and side effect free novel preservative has been greatly increased.
Amit Lather, Sunil Sharma, Anurag Khatkar   +2 more
doaj   +1 more source

Gold Nanoparticles Induced Size Dependent Cytotoxicity on Human Alveolar Adenocarcinoma Cells by Inhibiting the Ubiquitin Proteasome System

Pharmaceutics, 2023
Gold nanoparticles (AuNPs) are widely used in biomedicine due to their remarkable therapeutic applications. However, little is known about their cytotoxic effects on the ubiquitin proteasome system (UPS).
Bashiru Ibrahim, Taiwo Hassan Akere, Swaroop Chakraborty, Eugenia Valsami-Jones, Hanene Ali-Boucetta   +4 more
doaj   +1 more source

The role of ubiquitin-specific peptidases in cancer progression

Journal of Biomedical Science, 2019
Protein ubiquitination is an important mechanism for regulating the activity and levels of proteins under physiological conditions. Loss of regulation by protein ubiquitination leads to various diseases, such as cancer.
Ming-Jer Young, Kai-Cheng Hsu, Tony Eight Lin, Wen-Chang Chang, Jan-Jong Hung   +4 more
doaj   +1 more source