Results 41 to 50 of about 7,309,904 (153)

Investigating In Situ Expression of c-MYC and Candidate Ubiquitin-Specific Proteases in DLBCL and Assessment for Peptidyl Disruptor Molecule against c-MYC-USP37 Complex

Molecules, 2023
Diffuse Large B-Cell Lymphoma (DLBCL) is the most common form of non-Hodgkin’s lymphoma (NHL). Elevated expression of c-MYC in DLBCL is associated with poor prognosis of the disease.
Durr e Sameen Kamran, Mushtaq Hussain, Talat Mirza   +2 more
doaj   +1 more source

Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation [PDF]

, 2012
Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately ...
Amanda Denuc, Marfany Gemma, Denuc Isern, Amanda, Todi, S. V., Burr, A. A., Gemma Marfany, Blount Jessica R., Sokol V Todi, Todi Sokol V., Marfany i Nadal, Gemma, Jessica R Blount, Denuc Amanda, Blount, J. R., Aaron A Burr, Burr Aaron A.   +14 more
core   +2 more sources

Plant proteases [PDF]

, 2020
Plant proteases are involved in most aspects of plant physiology and development, playing key roles in the generation of signaling molecules and as regulators of essential cellular processes such as cell division and metabolism.
Guiamet, J, Van Breusegem, Frank, Guiamet, Juan, Diaz-Mendoza, M, Díaz Mendoza, María Mercedes   +4 more
core   +1 more source

Characterization of the deubiquitination activity and substrate specificity of the chicken ubiquitin-specific protease 1/USP associated factor 1 complex

PLOS ONE, 2017
Deubiquitinases (DUBs) are essential regulators of intracellular processes involving ubiquitin (Ub) modification. The human DUB ubiquitin-specific protease 1 (hUSP1) interacts with human USP-associated factor 1 (hUAF1), and helps to regulate processes such as DNA damage repair.
Hainan Zheng, Mengyun Wang, Chengcheng Zhao, Shanli Wu, Peifeng Yu, Yan Lü, Tiedong Wang, Yongxing Ai   +7 more
openaire   +4 more sources

BRCA1 is a histone-H2A-specific ubiquitin ligase [PDF]

, 2014
The RING domain proteins BRCA1 and BARD1 comprise a heterodimeric ubiquitin (E3) ligase that is required for the accumulation of ubiquitin conjugates at sites of DNA damage and for silencing at DNA satellite repeat regions. Despite its links to chromatin,
Donna L. Mallery, Mallery, D., Conor Larkin, Huang, Jeffrey T.J., Kalb, R., Kevin Hiom, Kalb, Reinhard, Reinhard Kalb, Huang, Jeffrey T. J.; id_orcid, Hiom, Kevin, Hiom, K., Jeffrey T.J. Huang, Larkin, C., Mallery, Donna L., Larkin, Conor, Huang, J.   +15 more
core   +1 more source

Marek’s disease virus (MDV) ubiquitin-specific protease (USP) performs critical functions beyond its enzymatic activity during virus replication

Virology, 2013
Marek's disease virus (MDV) encodes an ubiquitin-specific protease (USP) within its UL36 gene. USP is highly conserved among herpesviruses and was shown to be important for MDV replication and pathogenesis in MDV's natural host, the chicken. To further investigate the role of MDV USP, several recombinant (r) MDVs were generated and their in vitro ...
Veiga, Inês B., Jarosinski, Keith W., Kaufer, Benedikt B., Osterrieder, Nikolaus   +3 more
openaire   +2 more sources

Ubiquitin-specific peptidase 25 exacerbated osteoarthritis progression through facilitating TXNIP ubiquitination and NLRP3 inflammasome activation

Journal of Orthopaedic Surgery and Research, 2023
Several members of the ubiquitin-specific proteases (USPs) family have been revealed to regulate the progression of osteoarthritis (OA). The current study aimed to investigate the role and the underlying mechanism of USP25 in IL-1β-induced chondrocytes ...
Jie Sui, Fei Dai, Jiusheng Shi, Changcheng Zhou   +3 more
doaj   +1 more source

Roles of ubiquitin-specific proteases in inflammatory diseases

Frontiers in Immunology
Ubiquitin-specific proteases (USPs), as one of the deubiquitinating enzymes (DUBs) families, regulate the fate of proteins and signaling pathway transduction by removing ubiquitin chains from the target proteins.
Rui Chen, Rui Chen, Rui Chen, Hui Zhang, Hui Zhang, Linke Li, Linke Li, Jinsheng Li, Jiang Xie, Jie Weng, Huan Tan, Huan Tan, Yanjun Liu, Yanjun Liu, Tailin Guo, Tailin Guo, Mengyuan Wang, Mengyuan Wang, Mengyuan Wang   +18 more
doaj   +1 more source

USPs (Ubiquitin-specific proteases) SÃO DIFERENCIALMENTE EXPESSAS ATRAVÉS DO CILCO DE VIDA DO Schistosoma mansoni

, 2016
O processo de ubiquitinação é reversível e ocorre através das enzimas desubiquitinadoras (DUBs), as quais são proteases envolvidas no processamento de ubiquitinas e na reciclagem dos monômeros de ubiquitina das cadeias poliubiquinadas.
Guerra-Sá, Renata, Patrocinio, Andressa Barban do, Castro-Borges, William, Cabral, Fernanda J., Rodrigues, Vanderlei, Janotti- Passos, Liana K., de S. Gomes, Matheus, V. Pereira, Roberta, Baba, Elio. H., M. Souza, Daniel, P. Olmo, Roenick   +10 more
core   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source