Results 61 to 70 of about 7,309,904 (153)

Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling. [PDF]

PLoS ONE, 2013
Ubiquitination and deubiquitination have emerged as critical regulatory processes in the virus-triggered type I interferon (IFN) induction pathway.
Huijuan Zhong, Dang Wang, Liurong Fang, Huan Zhang, Rui Luo, Min Shang, Chao Ouyang, Haiping Ouyang, Huanchun Chen, Shaobo Xiao   +9 more
doaj   +1 more source

Interactions Between E3 Ubiquitin Ligases and Deubiquitinases in AKT Regulation: Implications in Skeletal Muscle Homeostasis

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT AKT (protein kinase B, PKB) coordinates the balance between anabolic and catabolic signaling in skeletal muscle through distinct ubiquitin chain types. Some E3 ubiquitin ligases (E3s) and deubiquitinases (DUBs) form stable binary complexes via non‐catalytic interfaces, adding a regulatory layer unavailable to either enzyme alone.
Rajesh Dabur
wiley   +1 more source

Ubiquitin-Specific Proteases as Potential Therapeutic Targets in Bladder Cancer—In Vitro Evaluation of Degrasyn and PR-619 Activity Using Human and Canine Models

Biomedicines, 2023
Background: The inhibition of ubiquitin-specific proteases (USPs) is a novel and promising direction in the development of molecularly targeted therapies in oncology.
Łukasz Nowak, Wojciech Krajewski, Ewa Dejnaka, Bartosz Małkiewicz, Tomasz Szydełko, Aleksandra Pawlak   +5 more
doaj   +1 more source

Plasma exosomal miR‐339‐3p promotes myocardial remodeling in chronic heart failure by regulating USP25‐mediated DDX58 deubiquitination

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
In the patients of chronic heart failure (HF), miR‐339‐3p derived from plasma exosomes can target ubiquitin‐specific protease 25, inhibiting its K48‐linked deubiquitination modification of DDX58, leading to increased ubiquitination and degradation of DDX58.
Guoqiang Jing, Ting Xu, Yuhong Ma
wiley   +1 more source

HucMSC exosomes promoted imatinib-induced apoptosis in K562-R cells via a miR-145a-5p/USP6/GLS1 axis

Cell Death and Disease, 2022
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm with increasing incidence worldwide. Growing evidence suggests that ubiquitin-specific proteases (USPs) play a role in cancer treatment.
Xiaowen Chen, Yixin Chen, Min Zhang, Hui Cheng, Huirong Mai, Meng Yi, Huanli Xu, Xiuli Yuan, Sixi Liu, Feiqiu Wen   +9 more
doaj   +1 more source

METTL14‐Mediated N6‐Methyladenosine Exacerbates Acute Lung Injury via USP30/NCOA4‐Dependent Ferroptosis

MedComm, Volume 7, Issue 9, September 2026.
METTL14‐mediated N6‐methyladenosine aggravates ischemia/reperfusion‐induced acute lung injury by enhancing YTHDF1‐dependent USP30 expression. USP30 stabilizes NCOA4 through deubiquitination, thereby promoting ferritinophagy, iron accumulation, lipid peroxidation, and ferroptosis in lung epithelial cells.
Aming Sang, Qiongyue Zhang, Xianwu Zhou, Xiaohua Wang, Jin Wang, Xuemin Song, Li Li, Ling Li, Xinyi Li   +8 more
wiley   +1 more source

Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein

Molecular Oncology, 2020
Hepatocellular carcinoma (HCC) has emerged as one of the most prevalent life‐threatening cancers, and the high mortality rate is largely due to the metastasis.
Tao Yuan, Zibo Chen, Fangjie Yan, Meijia Qian, Hong Luo, Song Ye, Ji Cao, Meidan Ying, Xiaoyang Dai, Renhua Gai, Bo Yang, Qiaojun He, Hong Zhu   +12 more
doaj   +1 more source

USP34 Haploinsufficiency as a Cause of Neurodevelopmental Phenotypes

Clinical Genetics, Volume 110, Issue 3, Page 315-324, September 2026.
Heterozygous loss‐of‐function variants in USP34 cause a novel neurodevelopmental disorder characterized by global developmental delay, speech impairment, autism, hypotonia, craniofacial dysmorphism, and distal limb anomalies. Disrupted Wnt/β‐catenin signaling via reduced Axin stabilization refines gene‐specific contributions within 2p15p16.1 ...
Helena Wigoda, Amjad Khan, Bryce A. Mendelsohn, Noriko Miyake, Nobuhiko Okamoto, Naomichi Matsumoto, Patricia J. C. Knijnenburg, Johanna M. van Hagen, Jiddeke van de Kamp, Quinten Waisfisz, Bryn D. Webb   +10 more
wiley   +1 more source

Analysis of substrate selectivity determinants in Ubiquitin Specific Proteases 11 and 15 [PDF]

, 2023
Ubiquitin Specific Proteases (USPs) have long been studied for various physiological effects, being involved in many cellular processes as well as many different cancers. The variety of the USP family as well as the large variation in substrates has made
Mayer, Matthias
core  

Expression and Role of Ubiquitin-Specific Peptidases in Osteoblasts

, 2021
The ubiquitin-proteasome system regulates biological processes in normal and diseased states. Recent investigations have focused on ubiquitin-dependent modifications and their impacts on cellular function, commitment, and differentiation.
René St-Arnaud, Hadla Hariri
core   +1 more source