Results 61 to 70 of about 1,825 (127)

USP54 Promotes Ferroptosis in Non‐Small Cell Lung Cancer by Mediating FOXA2 Deubiquitination and Enhancing ACSL4 Transcription

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 6, June 2026.
ABSTRACT Non‐small cell lung cancer (NSCLC) is the most common type of lung cancer, with a 5‐year survival rate of less than 20% and a high risk of recurrence despite advances in treatment. This study aimed to identify new therapeutic targets to increase the effectiveness of NSCLC treatments.
Rui‐Shi Wei, Yong‐Ping Liu, Chun‐Dong Gu, Shi‐Lei Zhao, Li Feng, Jian‐Rong Yu   +5 more
wiley   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Inhibitors Targeting SARS‐CoV‐2 Papain‐Like Protease: Screening, Design, Synthesis, and Biological Evaluation

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
In our study, we obtained both non‐covalent and covalent PLpro inhibitors. Additionally, the stable protein‐ligand interactions of the active compound were examined using advanced computational docking and molecular dynamics simulations. The non‐covalent inhibitor 2t showed antiviral activity with an EC50 of 2.89 µM, indicating its potential as a ...
Elena‐Oriana Iuga, Nilu Gone, Mariana Ortiz de Godoy, Gabriel Correa Verissimo, Giovanna de Jesus Agostinetto, Liam Urich, Nadine Krüger, Thales Kronenberger, Rafael Victorio Carvalho Guido, Anthony J. O’Donoghue, Stefan A. Laufer, Thanigaimalai Pillaiyar   +11 more
wiley   +1 more source

Ubiquitin-specific proteases in hepatitis: bridging molecular mechanisms and therapeutic potential

Egyptian Liver Journal
Hepatitis is a significant cause of severe liver diseases, including cirrhosis, liver failure, and hepatocellular carcinoma. Current strategies include antiviral drugs, vaccination, and liver transplantation; however, a potential therapeutic strategy is ...
Kavita Goyal, Muhammad Afzal, Ashok Kumar Bishoyi, R. Roopashree, Suman Saini, R. S. K. Sharma, Piyus Kumar Pathak, Ashish Singh Chauhan, Surendar Aravindhan, Mohd Imran, Abida Abida Abida   +10 more
doaj   +1 more source

Ubiquitin-specific proteases in ovarian cancer: molecular mechanisms and therapeutic implications

Journal of Ovarian Research
Ovarian cancer (OC) remains one of the most lethal gynecological malignancies, largely due to late-stage diagnosis, frequent recurrence, and the development of resistance to standard therapies.
Lu Deng, Yuzhao Jiang, Danning Wang, Jing Yu, Lingying Wu   +4 more
doaj   +1 more source

USP36 regulates the proliferation, survival, and differentiation of hFOB1.19 osteoblast

Journal of Orthopaedic Surgery and Research
Background Effective bone formation relies on osteoblast differentiation, a process subject to intricate post-translational regulation. Ubiquitin-specific proteases (USPs) repress protein degradation mediated by the ubiquitin-proteasome pathway.
Junfa Yan, Xiufei Gu, Xilin Gao, Yan Shao, Minghua Ji   +4 more
doaj   +1 more source

Overexpression of Ubiquitin-Specific Protease15 (USP15) Promotes Tumor Growth and Inhibits Apoptosis and Correlated With Poor Disease-Free Survival in Hepatocellular Carcinoma

Technology in Cancer Research & Treatment, 2020
USP15 is a member of ubiquitin-specific proteases (USPs, the largest subfamily of deubiquitinases) and functions as a stabilize factor of target proteins in reversible ubiquitiantion progression.
Xue-Qing Yao MA, Ling Li MA, Long-Zhen Piao PhD, Guang-Jian Zhang PhD, Xue-Zhu Huang PhD, Ying Wang MA, Zhe-Long Liang PhD   +6 more
doaj   +1 more source

Systematic discovery of motif-based interactions of the auxiliary domains of USP family deubiquitinases

Nature Communications
The ubiquitin-specific proteases (USPs) family is the largest family of human deubiquitinating enzymes (DUBs). While most USPs are agnostic to polyubiquitin linkage-type, their substrate specificity is thought to be mediated by the recognition of the ...
Aimiliani Konstantinou, Alicia Córdova-Pérez, Julia K. Varga, Priyanka Madhu, Leandro Simonetti, Maximilian Vieler, Ryosuke Ishimura, Frederic Lamoliatte, Ora Schueler-Furman, Norman E. Davey, Yogesh Kulathu, Ylva Ivarsson   +11 more
doaj   +1 more source

Unraveling the Mechanism of Action of Ubiquitin-Specific Protease 5 and Its Inhibitors in Tumors

Clinical Medicine Insights: Oncology
Ubiquitin-specific protease 5 (USP5), a member of the ubiquitin-specific proteases (USPs) family, functions by specifically removing ubiquitin chains from target proteins for stabilization and degrading unbound polyubiquitin chains to maintain a steady ...
Jie Wang, Shizhen Fang, Yang Jiang, Qingquan Hua   +3 more
doaj   +1 more source

USP48 promotes tumour progression through the deubiquitination and stabilization of DBF4 in clear cell renal carcinoma

Cancer Cell International
Background The upregulation of DBF4 is correlated with a poor prognosis in patients with clear cell renal cell carcinoma (ccRCC), yet the mechanisms governing the expression and protein stability of DBF4 remain unknown. Ubiquitin-specific proteases (USPs)
Lingfeng Zhu, Liuyan Chen, Lvying Wu, Na Lin, Wenyi Deng, Kuanyin Wang, Yaoyao Liang, Jianan Zhang, Jin Chen   +8 more
doaj   +1 more source