Results 71 to 80 of about 7,309,904 (153)
SFRP2 Potentiates Metastasis of Colon Cancer by Enhancing Snai1 Protein Stability via USP11
Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.ABSTRACT Metastatic colon cancer remains a significant clinical challenge, often associated with poor patient prognosis. Recent studies have identified the secreted frizzled‐related protein 2 (SFRP2) as a key player in this malignancy, showing its overexpression in metastatic cases.
Yanshen Kuang +6 more
wiley +1 more source
Defining the regulatory determinants in substrate catalysis by biochemical, biophysical, and kinetic studies for the development of specific small-molecule inhibitors of ubiquitin specific proteases 7 and 17 [PDF]
, 2016 Ubiquitination is an important post-translational modification involved in maintaining cellular homeostasis by regulating many delicate cellular processes, including the cell-cycle, membrane protein trafficking, endocytosis and apoptosis.
Hjortland, Nicole M.
core
Family C1 cysteine proteases: Biological diversity or redundancy? [PDF]
, 2003 Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes.
Nägler, D. K. +3 more
core +1 more source
Ubiquitin-specific proteases as cancer drug targets
, 2011 Ubiquitin-specific proteases are deubiquitinating enzymes involved in the removal of ubiquitin from specific protein substrates resulting in protein salvage from proteasome degradation, regulation of protein localization or activation.
Frédéric Colland +2 more
core +1 more source
Revista Colombiana de Química, 2014 This paper presents a combined approach with two aims. The first is to analyze the reported sequence of the enzyme ubiquitin carboxyl-terminal hydrolase 14 of Giardia intestinalis (UBP6) through computational methods to find components related with its ...
Magda E Alvarado +3 more
doaj +1 more source
Advanced Science, Volume 13, Issue 47, 24 August 2026.The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao +8 more
wiley +1 more source
High incidence of ubiquitin-like domains in human ubiquitin-specific proteases
, 2007 Ubiquitin-specific proteases (USPs) emerge as key regulators of numerous cellular processes and account for the bulk of human deubiquitinating enzymes (DUBs).
Menard, Robert, Sulea, Traian, Zhu, Xiao
core +1 more source
Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor [PDF]
, 2010 An important facet of transcriptional repression by Polycomb repressive complex 1 (PRC1) is the mono-ubiquitination of histone H2A by the combined action of the Posterior sex combs (Psc) and Sex combs extra (Sce) proteins.
Hiom, K +14 more
core +1 more source
Journal of Experimental & Clinical Cancer Research, 2023 Background The repressor element-1 silencing transcription factor (REST), a master transcriptional repressor, is essential for maintenance, self-renewal, and differentiation in neuroblastoma.
Janardhan Keshav Karapurkar +9 more
doaj +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.USP1, overexpressed in cervical cancer and linked to advanced pathological grade, promotes cervical cancer progression by deubiquitinating and stabilizing ATG13 to enhance autophagy, and USP1 inhibitor ML323 can reverse this oncogenic effect, making USP1 a promising therapeutic target for cervical cancer.
Chunyan Liu +4 more
wiley +1 more source