Results 71 to 80 of about 1,825 (127)

Ubiquitin‐specific protease 22 controls melanoma metastasis and vulnerability to ferroptosis through targeting SIRT1/PTEN/PI3K signaling

MedComm
Metastasis is a major contributing factor that affects the prognosis of melanoma patients. Nevertheless, the underlying molecular mechanisms involved in melanoma metastasis are not yet entirely understood.
Huiyan Sun, Yu Meng, Lei Yao, Songtao Du, Yayun Li, Qian Zhou, Yihuang Liu, Yating Dian, Yuming Sun, Xiaomin Wang, Xiao‐wei Liang, Guangtong Deng, Xiang Chen, Furong Zeng   +13 more
doaj   +1 more source

Ubiquitin-specific protease 11 suppresses cuproptosis in colorectal cancer by regulating the ubiquitination and stability of ISCU

Oncogenesis
Colorectal cancer (CRC) remains one of the most common and deadly malignancies, with limited effective treatment options. Cuproptosis is a novel regulated cell death triggered by mitochondrial copper overload (Cu2+) and has been implicated in several ...
Hailin Ke, Guowei Zhang, Weili Lin, Yuecui Jiang, Meina Wu, Yueyi Zhang, Weiyang Song, Fuhai Wang, Songling Yan   +8 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders

Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders
journal article Ubiquitination and deubiquitination are reversible processes that modify the characteristics of target proteins, including stability, intracellular localization, and enzymatic activity. Ubiquitin-specific proteases (USPs) constitute the largest deubiquitinating enzyme family.
openaire  

USP11 promotes colorectal cancer progression by stabilizing EGFR and TRAF6: a potential therapeutic target in EGFR- and TLR-driven tumorigenesis

Cell Death and Disease
Ubiquitin-specific proteases (USPs) are key regulators of protein homeostasis and have been implicated in various aspects of cancer development, including colorectal cancer (CRC). In this study, we investigated the role of USP11 in CRC pathogenesis.
Ji Hye Shin, Ji Young Kim, Seo Hyun Kim, Yeeun Kang, Ha-Jeong Lee, Mi-Jeong Kim, Jimin Choi, Soo-Kyung Jeong, Si-on Park, Yong Beom Cho, Kyeong Kyu Kim, Jae-Hyuck Shim, Eunyoung Chun, Ki-Young Lee   +13 more
doaj   +1 more source

USP48 functions as a suppressor of colorectal cancer via SELENBP1 stabilization

Translational Oncology
Aim: Colorectal cancer (CRC) is a leading cause of cancer-related death. SELENBP1 is a tumor suppressor in CRC. However, the mechanism regulating the stability of the SELENBP1 protein remains elusive.
Hongyue Lin, Ying Huang
doaj   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

USP25 in atherosclerosis: a new kid on the block. [PDF]

EBioMedicine
Ilyas I, Xu S.
europepmc   +1 more source

Ubiquitin-specific proteases as key regulators in the malignant progression and therapy resistance of colorectal cancer: current insights and future perspectives. [PDF]

Discov Oncol
Li J, Deng S, Yu W, Ye Q, Liu D, Yi Z, Liu C, Huang J, Zhong J, Wang X.   +9 more
europepmc   +1 more source