Results 91 to 100 of about 7,309,904 (153)

A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence [PDF]

, 2011
Intrinsic antiviral resistance represents the first line of intracellular defence against virus infection. During herpes simplex virus type-1 (HSV-1) infection this response can lead to the repression of viral gene expression but is counteracted by the ...
Delphine Cuchet-Lourenço, Roger D Everett, Roger D. Everett, Boutell Chris, McFarlane Steven, Cuchet, D., Mandy Glass, Steven McFarlane, Cuchet-Lourenço Delphine, Chris Boutell, Glass, M., Vanni, E., Orr Anne, Everett Roger D., McFarlane, S., Everett, R.D., Glass Mandy, Vanni Emilia, Boutell, C., Emilia Vanni, Anne Orr, Orr, A.   +21 more
core   +1 more source

The role of UBL domains in ubiquitin-specific proteases.

, 2012
Ubiquitin conjugation and deconjugation provides a powerful signalling system to change the fate of its target enzymes. Ubiquitination levels are organized through a balance between ubiquitinating E1, E2 and E3 enzymes and deubiquitination by DUBs ...
Faesen, A., Sixma, T., Luna-Vargas, M.
core   +1 more source

USP36 regulates the proliferation, survival, and differentiation of hFOB1.19 osteoblast

Journal of Orthopaedic Surgery and Research
Background Effective bone formation relies on osteoblast differentiation, a process subject to intricate post-translational regulation. Ubiquitin-specific proteases (USPs) repress protein degradation mediated by the ubiquitin-proteasome pathway.
Junfa Yan, Xiufei Gu, Xilin Gao, Yan Shao, Minghua Ji   +4 more
doaj   +1 more source

Overexpression of Ubiquitin-Specific Protease15 (USP15) Promotes Tumor Growth and Inhibits Apoptosis and Correlated With Poor Disease-Free Survival in Hepatocellular Carcinoma

Technology in Cancer Research & Treatment, 2020
USP15 is a member of ubiquitin-specific proteases (USPs, the largest subfamily of deubiquitinases) and functions as a stabilize factor of target proteins in reversible ubiquitiantion progression.
Xue-Qing Yao MA, Ling Li MA, Long-Zhen Piao PhD, Guang-Jian Zhang PhD, Xue-Zhu Huang PhD, Ying Wang MA, Zhe-Long Liang PhD   +6 more
doaj   +1 more source

Unraveling the Mechanism of Action of Ubiquitin-Specific Protease 5 and Its Inhibitors in Tumors

Clinical Medicine Insights: Oncology
Ubiquitin-specific protease 5 (USP5), a member of the ubiquitin-specific proteases (USPs) family, functions by specifically removing ubiquitin chains from target proteins for stabilization and degrading unbound polyubiquitin chains to maintain a steady ...
Jie Wang, Shizhen Fang, Yang Jiang, Qingquan Hua   +3 more
doaj   +1 more source

Mechanisms of USPs, and Sequential Cleavage of Ubiquitin Chains on PCNA by USP1/UAF1

In every cell in our body, proteins are the tiny molecular machines that carry out all the different functions of the cell, virtually performing every single active process in the human body.
Keijzer, Niels
core   +7 more sources

Diabetic cardiomyopathy as a disorder of proteostatic maladaptation: context-dependent ubiquitin-specific protease networks

Frontiers in Cell and Developmental Biology
Diabetic cardiomyopathy (DCM) is a multidimensional myocardial remodeling disorder driven by interconnected metabolic, inflammatory, ferroptotic, autophagic and fibrotic programs, yet the post-translational mechanisms that convert diabetic stress into ...
Xiangyun Meng, Shuming Guo, Hui Lin, Hui Lin, Ruchao Li, Ruchao Li, Wei Peng, Wei Peng, Lingang Sun, Lingang Sun, Xiaowei Shi, Lixia Yang, Lixia Yang, Lixia Yang   +13 more
doaj   +1 more source

Elucidating the catalytic and structural functions of ubiquitin specific proteases (USPs) 2 and 17

Ubiquitin is an essential regulatory protein, being the main component of the ubiquitination process, a post-translational modification whereby target proteins (substrates) are sent to the 26s proteasome for degradation.

core   +2 more sources

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Ubiquitin‐specific protease 22 controls melanoma metastasis and vulnerability to ferroptosis through targeting SIRT1/PTEN/PI3K signaling

MedComm
Metastasis is a major contributing factor that affects the prognosis of melanoma patients. Nevertheless, the underlying molecular mechanisms involved in melanoma metastasis are not yet entirely understood.
Huiyan Sun, Yu Meng, Lei Yao, Songtao Du, Yayun Li, Qian Zhou, Yihuang Liu, Yating Dian, Yuming Sun, Xiaomin Wang, Xiao‐wei Liang, Guangtong Deng, Xiang Chen, Furong Zeng   +13 more
doaj   +1 more source