Results 111 to 120 of about 1,825 (127)

Molecular regulation by ubiquitin-specific proteases (USPs) in HCC: cell cycle, oncogenic signaling, and beyond

Naunyn-Schmiedeberg's Archives of Pharmacology
Ubiquitin-specific proteases (USPs) are a large family of deubiquitinating enzymes that all serve the important function of removing ubiquitin moieties from target proteins, thereby maintaining cellular homeostasis. Post-translational modifications, including ubiquitin modifications, play a crucial role in regulating protein stability, localization ...
Subhashree Ray, Ali G Alkhathami, Roopashree R   +2 more
exaly   +3 more sources

Characterization of the Ubiquitin Specific Protease (USP) family members in the fast and slow muscle fibers from Chinese perch (Siniperca chuatsi)

Gene, 2018
Skeletal muscle atrophy results from fasting, disuse and other systemic diseases. Muscle atrophy is associated with increased muscle protein degradation via the Ubiquitin proteasome system (UPS). The Ubiquitin Specific Proteases (USPs), also known as deubiquitinating enzymes, regulates a wide variety of cellular processes in skeletal muscle.
FangLiang, Zhang, YuLong, Li, Lin, Chen, Jia, Cheng, Ping, Wu, WuYing, Chu, JianShe, Zhang   +6 more
openaire   +2 more sources

The role of ubiquitin‐specific protease 14 (USP14) in cell adhesion‐mediated drug resistance (CAM‐DR) of multiple myeloma cells

European Journal of Haematology, 2016
AbstractObjectiveCell adhesion‐mediated drug resistance (CAM‐DR) is one of the mechanisms underlying the drug resistance in multiple myeloma (MM). Ubiquitin‐specific protease 14 (USP14) is downregulated in the apoptotic model and upregulated in the adhesive model of MM.
Xiaohong, Xu, Jing, Liu, Chaoyan, Shen, Linlin, Ding, Fei, Zhong, Yu, Ouyang, Yuchan, Wang, Song, He   +7 more
openaire   +2 more sources

A ubiquitin specific protease (USP) network regulates wnt/β-catenin activity in myeloid leukemia cells

Blood
Abstract Canonical Wnt signalling is an important regulator of haematopoietic stem/progenitor cells (HSPC) and frequently dysregulated in myeloid neoplasms. Overexpression, overactivity or mislocalisation of the central mediator β-catenin has been reported in multiple acute myeloid leukaemia ...
Megan Wagstaff, Okan Sevim, Maddie Harrison, Brandon Coke, Allison Blair, Timothy Chevassut, Ethan Morgan, Rhys Morgan   +7 more
openaire   +1 more source

Abstract 3665: Insilco evaluation of multiple ubiquitin-specific protease 1 (USP1) inhibitors and selectivity profiling over other USPs using Alphafold

Cancer Research
Abstract DNA damage triggers cell signaling cascades that mediate repair. This signaling is frequently dysregulated in cancers. The proteins that mediate this signaling are potential targets for therapeutic intervention. Ubiquitin-specific protease 1 (USP1) is one such target, with small-molecule inhibitors already in clinical trials ...
Prashant Kashinath Bhavar, Uday Kumar Surampudi, Appaji Baburao Mandhare, Rupesh Chikhale   +3 more
openaire   +1 more source

Ubiquitin-specific proteases: Vital regulatory molecules in bone and bone-related diseases

International Immunopharmacology, 2023
Yingying Wu, Yi Xiong, Wenxin Luo
exaly  

The Roles of Ubiquitin-Specific Proteases (USPs) in Cancer Stem Cell Maintenance

Kuan Ping Ang, Won Fen Wong, Chung Yeng Looi   +2 more
openaire   +1 more source

Faculty Opinions recommendation of An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2016
openaire   +1 more source

Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics

Breast Cancer Research and Treatment, 2006
Hongying Zhou, Shishan Deng, Zhou Hongying   +2 more
exaly