Results 101 to 110 of about 7,309,904 (153)

Correction: Correction: Regulation of Neuronal Morphogenesis and Positioning by Ubiquitin-Specific Proteases in the Cerebellum

, 2015
Correction: Correction: Regulation of Neuronal Morphogenesis and Positioning by Ubiquitin-Specific Proteases in the ...
PLOS ONE (2189197)
core   +1 more source

Functional study of ubiquitin C-terminal hydrolase-L1 gene promoter haplotypes

, 2007
The Ubiquitin Conjugating System (UCS) describes a system in which the 96-amino acid residue Ubiquitin can be selectively covalently linked to intracellular proteins.
Sanassy, Shane
core   +1 more source

Analysis of substrate selectivity determinants in Ubiquitin Specific Proteases 11 and 15 [PDF]

Ubiquitin Specific Proteases (USPs) have long been studied for various physiological effects, being involved in many cellular processes as well as many different cancers. The variety of the USP family as well as the large variation in substrates has made
Mayer, Matthias
core   +2 more sources

Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders

Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders
journal article Ubiquitination and deubiquitination are reversible processes that modify the characteristics of target proteins, including stability, intracellular localization, and enzymatic activity. Ubiquitin-specific proteases (USPs) constitute the largest deubiquitinating enzyme family.
openaire   +1 more source

USP11 promotes colorectal cancer progression by stabilizing EGFR and TRAF6: a potential therapeutic target in EGFR- and TLR-driven tumorigenesis

Cell Death and Disease
Ubiquitin-specific proteases (USPs) are key regulators of protein homeostasis and have been implicated in various aspects of cancer development, including colorectal cancer (CRC). In this study, we investigated the role of USP11 in CRC pathogenesis.
Ji Hye Shin, Ji Young Kim, Seo Hyun Kim, Yeeun Kang, Ha-Jeong Lee, Mi-Jeong Kim, Jimin Choi, Soo-Kyung Jeong, Si-on Park, Yong Beom Cho, Kyeong Kyu Kim, Jae-Hyuck Shim, Eunyoung Chun, Ki-Young Lee   +13 more
doaj   +1 more source

Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases.

, 2005
There's always a catch. The post-translational modification of proteins with ubiquitin (Ub) or ubiquitin-like (Ubl) modifiers is an important signal in the regulation of a variety of biological processes, such as degradation and regulation of gene ...
Ploegh, HL, Meester, WJ, Overkleeft, HS, Ovaa, H, Hekking, BG, Kessler, BM, Venanzi, ES, Borodovsky, A, Bogyo, MS   +8 more
core   +1 more source

USP45 Represses Melanoma Development by Deubiquitinating and Stabilizing Tumor Suppressor MRGPRF

Advanced Science
Melanoma, a highly malignant skin cancer, has seen a rising incidence and death toll. MRGPRF is a novel melanoma suppressor that inhibits the PI3K/AKT pathway. However, the regulation of MRGPRF in melanoma remains unclear.
Wancong Zhang, Liyun Chen, Jing Zhao, Aiwei Ma, Wenqi Shi, Yiwen Zhang, Zixuan Tang, Jiarui Guo, Zaihua Xu, Jianda Zhou, Shijie Tang   +10 more
doaj   +1 more source

Hypermethylated USP44 deubiquitinates SENP2: a critical mechanism in esophageal cancer progression and a new target for intervention

Clinical Epigenetics
Background Ubiquitin-specific proteases (USPs) play a critical role in the development of various cancers. The study aimed to elucidated the pathogenic molecular mechanisms and analyze its clinical significance in esophageal squamous cell carcinoma (ESCC)
Haibo Wu, Xinke Zhang, Zhengyi Zhou, Keming Chen, Jierong Chen, Chao Ma, Jinling Duan, Yingqing Li, Jiewei Chen   +8 more
doaj   +1 more source

The Ubiquitin-Specific Protease Family: Master Regulators of Renal Fibrosis Pathogenesis and Therapeutic Targets. [PDF]

Int J Mol Sci
Wang Y, Ren D, Zhao W, Zhang Y, Zhang X.
europepmc   +1 more source

Structural insights into ubiquitin recognition by USP15 revealed through a covalent activity-based probe. [PDF]

Commun Biol
Liu B, Wang T, Luo H, Lang L, Liu X, Gong Z, Wang T, Cheng W, Xie L, Zhang X, Fang X, Xu X.   +11 more
europepmc   +1 more source