Results 11 to 20 of about 33,030 (228)

Ubiquitin-specific proteases are differentially expressed throughout the Schistosoma mansoni life cycle [PDF]

Parasites & Vectors, 2015
Background The ubiquitination process can be reversed by deubiquitinating enzymes (DUBs). These proteases are involved in ubiquitin processing, in the recovery of modified ubiquitin trapped in inactive forms, and in the recycling of ubiquitin monomers ...
Roberta V. Pereira, Matheus de S Gomes, Roenick P. Olmo, Daniel M. Souza, Fernanda J. Cabral, Liana K. Jannotti-Passos, Elio H. Baba, Andressa B. P. Andreolli, Vanderlei Rodrigues, William Castro-Borges, Renata Guerra-Sá   +10 more
doaj   +2 more sources

Identification and Validation of Ubiquitin-Specific Proteases as a Novel Prognostic Signature for Hepatocellular Carcinoma [PDF]

Frontiers in Oncology, 2021
PurposeUbiquitin-specific proteases (USPs), as a sub-family of deubiquitinating enzymes (DUBs), are responsible for the elimination of ubiquitin-triggered modification. USPs are recently correlated with various malignancies.
Wenkai Ni, Wenkai Ni, Saiyan Bian, Saiyan Bian, Mengqi Zhu, Qianqian Song, Jianping Zhang, Mingbing Xiao, Wenjie Zheng   +8 more
doaj   +2 more sources

An insight into the roles of ubiquitin-specific proteases in plants: development and growth, morphogenesis, and stress response [PDF]

Frontiers in Plant Science
Ubiquitination is a highly conserved and dynamic post-translational modification in which protein substrates are modified by ubiquitin to influence their activity, localization, or stability. Deubiquitination enzymes (DUBs) counter ubiquitin signaling by
Xiuwen Wang, Xiuwen Wang, Xuan Liu, Xuan Liu, Kaixuan Song, Kaixuan Song, Liang Du, Liang Du   +7 more
doaj   +2 more sources

Ubiquitin-specific proteases as key regulators in the malignant progression and therapy resistance of colorectal cancer: current insights and future perspectives [PDF]

Discover Oncology
As a member of the DUBs (deubiquitinating enzymes) family, USPs (ubiquitin-specific peptidases) play a crucial regulatory role in the occurrence and progression of various malignancies.
Junyan Li, Shifan Deng, Wei Yu, Qian Ye, Dongxing Liu, Zhiling Yi, Chuanjian Liu, Jixiang Huang, Jinghua Zhong, Xiangcai Wang   +9 more
doaj   +2 more sources

Molecular Mechanisms of the Ubiquitin-Specific Proteases (USPs) Family in Biliary Tract Cancer and Targeted Intervention Strategies [PDF]

Biomedicines
Biliary tract carcinoma (BTC) is a group of highly heterogeneous malignancies arising from the biliary epithelium. Anatomically, BTC is categorized into gallbladder cancer (GBC) and cholangiocarcinoma (CCA), with the latter further subdivided into ...
Qian Cheng, Delin Ma, Shengmin Zheng, Jialing Hao, Gang Wang, Yanbin Ni, Jiye Zhu   +6 more
doaj   +2 more sources

Role of ubiquitin-specific proteases in programmed cell death of breast cancer cells [PDF]

Genes and Diseases
Breast cancer (BC) is the most common malignant tumor and the leading cause of cancer-related deaths among women worldwide. Great progress has been recently achieved in controlling breast cancer; however, mortality from breast cancer remains a ...
Wen Yan, Shasha Xiang, Jianbo Feng, Xuyu Zu   +3 more
doaj   +2 more sources

Drug resistance mechanisms and treatment strategies mediated by Ubiquitin-Specific Proteases (USPs) in cancers: new directions and therapeutic options [PDF]

Molecular Cancer
Drug resistance represents a significant obstacle in cancer treatment, underscoring the need for the discovery of novel therapeutic targets. Ubiquitin-specific proteases (USPs), a subclass of deubiquitinating enzymes, play a pivotal role in protein ...
Hongli Gao, Zhuo Xi, Jingwei Dai, Jinqi Xue, Xin Guan, Liang Zhao, Zhiguang Chen, Fei Xing   +7 more
doaj   +2 more sources

Regulation of neuronal morphogenesis and positioning by ubiquitin-specific proteases in the cerebellum. [PDF]

PLoS ONE, 2015
Ubiquitin signaling mechanisms play fundamental roles in the cell-intrinsic control of neuronal morphogenesis and connectivity in the brain. However, whereas specific ubiquitin ligases have been implicated in key steps of neural circuit assembly, the ...
Julius Anckar, Azad Bonni
doaj   +2 more sources

Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling. [PDF]

PLoS ONE, 2013
Ubiquitination and deubiquitination have emerged as critical regulatory processes in the virus-triggered type I interferon (IFN) induction pathway.
Huijuan Zhong, Dang Wang, Liurong Fang, Huan Zhang, Rui Luo, Min Shang, Chao Ouyang, Haiping Ouyang, Huanchun Chen, Shaobo Xiao   +9 more
doaj   +2 more sources

Emerging potential of ubiquitin-specific proteases and ubiquitin-specific proteases inhibitors in breast cancer treatment. [PDF]

World J Clin Cases, 2022
Breast cancer is the most frequently diagnosed cancer in women, accounting for 30% of new diagnosing female cancers. Emerging evidence suggests that ubiquitin and ubiquitination played a role in a number of breast cancer etiology and progression processes. As the primary deubiquitinases in the family, ubiquitin-specific peptidases (USPs) are thought to
Huang ML, Shen GT, Li NL.
europepmc   +3 more sources