USP7 Inhibition Alleviates H2O2-Induced Injury in Chondrocytes via Inhibiting NOX4/NLRP3 Pathway
Frontiers in Pharmacology, 2021 Osteoarthritis (OA), the most common form of arthritis, is a very common joint disease that often affects middle-aged to elderly people. However, current treatment options for OA are predominantly palliative.
Gang Liu +5 more
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Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling. [PDF]
PLoS ONE, 2013 Ubiquitination and deubiquitination have emerged as critical regulatory processes in the virus-triggered type I interferon (IFN) induction pathway.
Huijuan Zhong +9 more
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SUMO-specific Isopeptidases Tuning Cardiac SUMOylation in Health and Disease
Frontiers in Molecular Biosciences, 2021 SUMOylation is a transient posttranslational modification with small-ubiquitin like modifiers (SUMO1, SUMO2 and SUMO3) covalently attached to their target-proteins via a multi-step enzymatic cascade.
Paul W. Hotz +2 more
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Family C1 cysteine proteases: Biological diversity or redundancy? [PDF]
, 2003 Recent progress in the identification and partial characterization of novel genes encoding cysteine proteases of the papain family has considerably increased our knowledge of this family of enzymes.
Nägler, D. K. +3 more
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Rsp5 Ubiquitin Ligase Is Required for Protein Trafficking in Saccharomyces cerevisiae COPI Mutants [PDF]
, 2012 Retrograde trafficking from the Golgi to the endoplasmic reticulum (ER) depends on the formation of vesicles coated with the multiprotein complex COPI.
Joanna Kaminska +7 more
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Varions Mechanisms of Deubiquitinating Enzyme USP22 in Cancer
Zhongliu Fangzhi Yanjiu, 2020 Ubiquitin specific proteases 22 (USP22) is a highly conserved ubiquitin hydrolase in mammals. It mainly prevents proteins degradation by deubiquitinating substrate proteins and regulates life processes such as genetic transcription, DNA damage repair and
SUN Yue, HAN Bing, ZHEN Fang, HU Jing
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Emerging Roles of Ubiquitin-Specific Protease 25 in Diseases [PDF]
Frontiers in Cell and Developmental Biology, 2021 The balance of ubiquitination and deubiquitination plays diverse roles in regulating protein stability and cellular homeostasis. Deubiquitinating enzymes catalyze the hydrolysis and removal of ubiquitin chains from target proteins and play critical roles in various disease processes, including cancer, immune responses to viral infections and ...
Wenjing Zhu +6 more
openaire +3 more sources
Small ubiquitin-like modifier protein SUMO enables plants to control growth independently of the phytohormone gibberellin [PDF]
, 2014 Plants survive adverse conditions by modulating their growth in response to a changing environment. Gibberellins (GAs) play a key role in these adaptive responses by stimulating the degradation of growth-repressing DELLA proteins.
Bennett, M. +33 more
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A ubiquitin-specific protease that efficiently cleaves the ubiquitin-proline bond.
, 2022 Ubiquitin is a small eukaryotic protein that is synthesized naturally as one of several fusion proteins, which are processed by ubiquitin-specific proteases to release free ubiquitin.
Gilchrist, CA, Gray, DA, Baker, RT
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SUMO chain-induced dimerization activates RNF4 [PDF]
, 2014 Dimeric RING E3 ligases interact with protein substrates and conformationally restrain the ubiquitin-E2-conjugating enzyme thioester complex such that it is primed for catalysis.
Hay, Ronald T +5 more
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