Drug resistance mechanisms and treatment strategies mediated by Ubiquitin-Specific Proteases (USPs) in cancers: new directions and therapeutic options [PDF]
Molecular CancerDrug resistance represents a significant obstacle in cancer treatment, underscoring the need for the discovery of novel therapeutic targets. Ubiquitin-specific proteases (USPs), a subclass of deubiquitinating enzymes, play a pivotal role in protein ...
Hongli Gao +7 more
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Regulation of neuronal morphogenesis and positioning by ubiquitin-specific proteases in the cerebellum. [PDF]
PLoS ONE, 2015 Ubiquitin signaling mechanisms play fundamental roles in the cell-intrinsic control of neuronal morphogenesis and connectivity in the brain. However, whereas specific ubiquitin ligases have been implicated in key steps of neural circuit assembly, the ...
Julius Anckar, Azad Bonni
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Emerging potential of ubiquitin-specific proteases and ubiquitin-specific proteases inhibitors in breast cancer treatment. [PDF]
World J Clin Cases, 2022 Breast cancer is the most frequently diagnosed cancer in women, accounting for 30% of new diagnosing female cancers. Emerging evidence suggests that ubiquitin and ubiquitination played a role in a number of breast cancer etiology and progression processes. As the primary deubiquitinases in the family, ubiquitin-specific peptidases (USPs) are thought to
Huang ML, Shen GT, Li NL.
europepmc +3 more sources
Corrigendum: Roles of ubiquitin-specific proteases in inflammatory diseases [PDF]
Frontiers in ImmunologyRui Chen +18 more
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Correction: Ubiquitin-specific proteases (USPs) in leukemia: a systematic review [PDF]
BMC CancerAlireza Zangooie +9 more
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Ubiquitin specific peptidases and prostate cancer [PDF]
PeerJ, 2023 Protein ubiquitination is an important post-translational modification mechanism, which regulates protein stability and activity. The ubiquitination of proteins can be reversed by deubiquitinating enzymes (DUBs).
Yunfei Guo +4 more
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Screen for ISG15-crossreactive deubiquitinases. [PDF]
PLoS ONE, 2007 The family of ubiquitin-like molecules (UbLs) comprises several members, each of which has sequence, structural, or functional similarity to ubiquitin. ISG15 is a homolog of ubiquitin in vertebrates and is strongly upregulated following induction by type
André Catic +5 more
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ElaD, a Deubiquitinating protease expressed by E. coli. [PDF]
PLoS ONE, 2007 BACKGROUND: Ubiquitin and ubiquitin-like proteins (Ubl) are designed to modify polypeptides in eukaryotes. Covalent binding of ubiquitin or Ubls to substrate proteins can be reversed by specific hydrolases.
André Catic +3 more
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, 2020 Plant proteases are involved in most aspects of plant physiology and development, playing key roles in the generation of signaling molecules and as regulators of essential cellular processes such as cell division and metabolism.
Guiamet, J +4 more
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Research progress on ubiquitin-specific proteases in regulation of bone remodeling
口腔疾病防治, 2022 Maintaining bone homeostasis relies on the balance between bone remodeling involving bone resorption by osteoclasts and bone formation by osteoblasts under physiological conditions. An increasing number of studies have shown that the ubiquitin-proteasome
ZHANG Guorui, WU Yingying, XIONG Yi
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