Results 31 to 40 of about 33,030 (228)
SUMO Takes Control of a Ubiquitin-Specific Protease [PDF]
Molecular Cell, 2008 In this issue of Molecular Cell, Meulmeester et al. (2008) identify USP25 as a SUMO2/3-interacting protein and substrate. A USP25 SUMO interaction motif directs SUMO2/3 specificity, and SUMO modification diminishes USP25's ability to bind and degrade polyubiquitin chains.
Mohideen, Firaz, Lima, Christopher D.
openaire +2 more sources
Correction: Correction: Regulation of Neuronal Morphogenesis and Positioning by Ubiquitin-Specific Proteases in the Cerebellum. [PDF]
PLoS ONE, 2015 PLOS ONE Staff
doaj +2 more sources
USP7 Inhibition Alleviates H2O2-Induced Injury in Chondrocytes via Inhibiting NOX4/NLRP3 Pathway
Frontiers in Pharmacology, 2021 Osteoarthritis (OA), the most common form of arthritis, is a very common joint disease that often affects middle-aged to elderly people. However, current treatment options for OA are predominantly palliative.
Gang Liu +5 more
doaj +1 more source
SUMO-specific Isopeptidases Tuning Cardiac SUMOylation in Health and Disease
Frontiers in Molecular Biosciences, 2021 SUMOylation is a transient posttranslational modification with small-ubiquitin like modifiers (SUMO1, SUMO2 and SUMO3) covalently attached to their target-proteins via a multi-step enzymatic cascade.
Paul W. Hotz +2 more
doaj +1 more source
Varions Mechanisms of Deubiquitinating Enzyme USP22 in Cancer
Zhongliu Fangzhi Yanjiu, 2020 Ubiquitin specific proteases 22 (USP22) is a highly conserved ubiquitin hydrolase in mammals. It mainly prevents proteins degradation by deubiquitinating substrate proteins and regulates life processes such as genetic transcription, DNA damage repair and
SUN Yue, HAN Bing, ZHEN Fang, HU Jing
doaj +1 more source
Frontiers in Bioscience-Landmark, 2022 Background: Ubiquitination is one of the most common post-translational modifications in cells and dysregulation is closely associated with the development of cancer.
Weijie Sun +5 more
doaj +1 more source
Emerging Roles of Ubiquitin-Specific Protease 25 in Diseases [PDF]
Frontiers in Cell and Developmental Biology, 2021 The balance of ubiquitination and deubiquitination plays diverse roles in regulating protein stability and cellular homeostasis. Deubiquitinating enzymes catalyze the hydrolysis and removal of ubiquitin chains from target proteins and play critical roles in various disease processes, including cancer, immune responses to viral infections and ...
Wenjing Zhu +6 more
openaire +3 more sources
Research advances in the role of ubiquitin-specific protease 25 in different malignant tumors [PDF]
精准医学杂志Ubiquitin-specific protease 25 (USP25) is an important member of the seven major families of deubiquitinating enzymes (DUBs), and it can exert a deubiquitinating effect on substrate proteins and activate different signaling pathways, thereby regulating ...
FENG Na, ZHANG Qing, FANG Haotian, LI Qingshan, XU Fan
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source