Results 31 to 40 of about 7,340,584 (263)

Correction: Regulation of Neuronal Morphogenesis and Positioning by Ubiquitin-Specific Proteases in the Cerebellum. [PDF]

PLoS ONE, 2015
PLOS ONE Staff
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Divergent ubiquitin interactions among ubiquitin specific proteases and development of small molecule DUB inhibitors

, 2022
Zhuang, ZhihaoDeubiquitinating enzymes (DUBs) are responsible for reversing mono- and poly-ubiquitination of proteins and play essential roles in numerous cellular processes.
Tencer, Adam
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Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation [PDF]

, 2012
Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately ...
Amanda Denuc, Marfany Gemma, Denuc Isern, Amanda, Todi, S. V., Burr, A. A., Gemma Marfany, Blount Jessica R., Sokol V Todi, Todi Sokol V., Marfany i Nadal, Gemma, Jessica R Blount, Denuc Amanda, Blount, J. R., Aaron A Burr, Burr Aaron A.   +14 more
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BRCA1 is a histone-H2A-specific ubiquitin ligase [PDF]

, 2014
The RING domain proteins BRCA1 and BARD1 comprise a heterodimeric ubiquitin (E3) ligase that is required for the accumulation of ubiquitin conjugates at sites of DNA damage and for silencing at DNA satellite repeat regions. Despite its links to chromatin,
Donna L. Mallery, Mallery, D., Conor Larkin, Huang, Jeffrey T.J., Kalb, R., Kevin Hiom, Kalb, Reinhard, Reinhard Kalb, Huang, Jeffrey T. J.; id_orcid, Hiom, Kevin, Hiom, K., Jeffrey T.J. Huang, Larkin, C., Mallery, Donna L., Larkin, Conor, Huang, J.   +15 more
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Systematic characterization of the ubiquitin-specific proteases in Magnaporthe oryzae

Phytopathology Research, 2020
Ubiquitin-specific protease (UBP) family is the largest group of deubiquitinases, which plays important roles in eukaryotic organisms. Comprehensive analysis of UBP genes has not been conducted in the plant pathogenic fungi.
Xuan Cai, Zhao Wang, Yuxi Hou, Caiyun Liu, Ahmed Hendy, Junjie Xing, Xiao-Lin Chen   +6 more
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SUMO Takes Control of a Ubiquitin-Specific Protease [PDF]

Molecular Cell, 2008
In this issue of Molecular Cell, Meulmeester et al. (2008) identify USP25 as a SUMO2/3-interacting protein and substrate. A USP25 SUMO interaction motif directs SUMO2/3 specificity, and SUMO modification diminishes USP25's ability to bind and degrade polyubiquitin chains.
Mohideen, Firaz, Lima, Christopher D.
openaire   +2 more sources

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry [PDF]

, 2014
Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive
Virdee, Satpal; id_orcid, Gray, Nathanael, Trost, Matthias, Ritorto, Maria Stella, Gray, Nathanael S., Alessi, Dario R., Perez-Oliva, Ana B., Wood, Nicola T., Alessi, Dario R.; id_orcid, Knebel, Axel, Buhrlage, Sara J., Ewan, Richard, Wightman, Melanie, Morrice, Nicholas A., Virdee, Satpal, Kelly, Sharon M.   +15 more
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Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1 [PDF]

Cell Discovery, 2015
AbstractThe elevated level of CCNB1 indicates more aggressive cancer and poor prognosis. However, the factors that cause CCNB1 upregulation remain enigmatic. Herein, we identify USP22 as a CCNB1 interactor and discover that both USP22 and CCNB1 are dramatically elevated with a strong positive correlation in colon cancer tissues.
Lin, Zhenghong, Tan, Can, Qiu, Quan, Kong, Sinyi, Yang, Heeyoung, Zhao, Fang, Liu, Zhaojian, Li, Jinping, Kong, Qingfei, Gao, Beixue, Barrett, Terry, Yang, Guang-Yu, Zhang, Jianing, Fang, Deyu   +13 more
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The regulatory complex of Drosophila melanogaster 26S proteasomes : subunit composition and localization of a deubiquitylating enzyme [PDF]

, 2000
Drosophila melanogaster embryos are a source for homogeneous and stable 26S proteasomes suitable for structural studies. For biochemical characterization, purified 26S proteasomes were resolved by two- dimensional (2D) gel electrophoresis and subunits ...
Harald Hölzl, Kapelari, B., Müller, S., Sperling, J., Wolfgang Baumeister, Medalia, O., Erika Seemüller, Holzl, H., Seemuller, E., Baumeister, W., Udvardy, A., Andor Udvardy, Engel, A., Kellermann, J., Joseph Sperling, Josef Kellermann, Sumegi, M., Müller, S. A., Máté Sümegi, Ohad Medalia, Andreas Engel, Barbara Kapelari, Shirley A. Müller   +22 more
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Generation and physiological roles of linear ubiquitin chains [PDF]

, 2012
Ubiquitination now ranks with phosphorylation as one of the best-studied post-translational modifications of proteins with broad regulatory roles across all of biology.
Iwai Kazuhiro, Walczak, H, Walczak, Henning, Kazuhiro Iwai, Walczak Henning, Đikić, Ivan, Ivan Dikic, Iwai, Kazuhiro, Iwai, K, Dikic, I, Dikic Ivan, Henning Walczak   +11 more
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