Results 41 to 50 of about 22,435 (241)

The roles of protein ubiquitination in tumorigenesis and targeted drug discovery in lung cancer

Frontiers in Endocrinology, 2023
The malignant lung cancer has a high morbidity rate and very poor 5-year survival rate. About 80% - 90% of protein degradation in human cells is occurred through the ubiquitination enzyme pathway.
Zhen Ye, Zhen Ye, Jingru Yang, Hanming Jiang, Xianquan Zhan   +4 more
doaj   +1 more source

Deubiquitinating Function of Adenovirus Proteinase [PDF]

Journal of Virology, 2002
ABSTRACT The invasion strategy of many viruses involves the synthesis of viral gene products that mimic the functions of the cellular proteins and thus interfere with the key cellular processes. Here we show that adenovirus infection is accompanied by an increased ubiquitin-cleaving (deubiquitinating) activity in the host cells.
Maxim Y, Balakirev, Michel, Jaquinod, Arthur L, Haas, Jadwiga, Chroboczek   +3 more
openaire   +2 more sources

DNA methylation in chromatin - complexes and mechanisms [PDF]

, 2010
The DNA in the eukaryotic genome is packaged into chromatin whose basic repeating unit is the nucleosome consisting of 147bp of DNA wrapped around an octameric histone core.
Felle, Max
core   +1 more source

Emerging role of deubiquitination modifications of programmed death-ligand 1 in cancer immunotherapy

Frontiers in Immunology, 2023
Immune evasion is essential for carcinogenesis and cancer progression. Programmed death-ligand 1 (PD-L1), a critical immune checkpoint molecule, interacts with programmed death receptor-1 (PD-1) on immune cells to suppress anti-tumor immune responses. In
Yao Jiang, Yao Jiang, Kai Hong, Yingchao Zhao, Yingchao Zhao, Kai Xu   +5 more
doaj   +1 more source

A plague of deubiquitination [PDF]

The Journal of Experimental Medicine, 2005
Plague bacteria inject infected host cells with a ubiquitin-chopping enzyme, according to Zhou and colleagues in a study on [page 1327][1]. The group shows that the virulence factor YopJ operates as a deubiquitinase to shut down multiple signaling pathways that would otherwise help trigger ...
openaire   +1 more source

Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actions

Fundamental Research
Post-transcriptional epigenetic modifications provide numerous implications for tumor progression, metastasis and recurrence, which also pose resistances to reactive oxygen species (ROS)-based anti-tumor.
Yan Zhang, Dou Du, Chao Fang, Xin Yu, Yujia Fang, Xinyu Liu, Di Ou, Haohao Yin, Hui Liu, Taixia Wang, Lu Lu, Xiaolong Li, Kun Zhang   +12 more
doaj   +1 more source

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones.

, 2019
peer reviewedUbiquitination is a post-translational modification that plays important roles in various signaling pathways and is notably involved in the coordination of chromatin function and DNA-associated processes.
Boubekeur, Amina, Masclef, Louis, Barbour, Haithem, Iannantuono, Nicholas V G, Uriarte, Maxime, Ahmed, Oumaima, Daou, Salima, Sen Nkwe, Nadine, Affar, El Bachir   +8 more
core   +1 more source

USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination

Frontiers in Genetics, 2020
Snail is a prominent epithelial–mesenchymal transition (EMT) transcription factor and promotes metastasis. However, Snail protein is unstable and is quickly degraded through ubiquitination-mediated proteasome pathway.
Jiali Cai, Mengying Li, Xiang Wang, Lei Li, Qi Li, Zhaoyuan Hou, Zhaoyuan Hou, Zhaoyuan Hou, Hao Jia, Hao Jia, Shiyuan Liu   +10 more
doaj   +1 more source

A Novel Type of Deubiquitinating Enzyme [PDF]

Journal of Biological Chemistry, 2003
A previous report from this laboratory described two novel proteins that have sequence similarity to A20, a negative regulator of NF-kappaB (Evans, P. C., Taylor, E. R., Coadwell, J., Heyninck, K., Beyaert, R., and Kilshaw, P. J. (2001) Biochem. J. 357, 617-623).
Paul C, Evans, Trevor S, Smith, Meng-Jiun, Lai, Mark G, Williams, David F, Burke, Karen, Heyninck, Marja M, Kreike, Rudi, Beyaert, Tom L, Blundell, Peter J, Kilshaw   +9 more
openaire   +2 more sources

Deubiquitinase USP38 Stabilizes PLK1 Expression to Boost DNA Damage Repair in Ovarian Cancer. [PDF]

Kaohsiung J Med Sci
ABSTRACT Ovarian cancer (OC) is one of the most prevalent and severe gynecological malignant tumors. DNA damage repair (DDR) is essential in maintaining genome stability. This study aims to investigate the effects and mechanisms of USP38 and PLK1 on DNA damage repair and malignant behavior in OC cells.
Ma Y, Li Y, Li KL.
europepmc   +2 more sources