Results 31 to 40 of about 19,734 (206)
eLife, 2020 Protein ubiquitination is a very diverse post-translational modification leading to protein degradation or delocalization, or altering protein activity. In Arabidopsis thaliana, two E3 ligases, BIG BROTHER (BB) and DA2, activate the latent peptidases DA1,
Hannes Vanhaeren +10 more
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Nature Communications, 2019 In the Fanconi anemia pathway, deubiquitination of FANCD2 is a fundamental regulatory step. Here, the authors have developed a set of biochemical tools to reconstitute FANCD2 deubiquitination by recombinant USP1-UAF1-RAD51AP1 and reveal critical ...
Fengshan Liang +9 more
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USP7: Novel Drug Target in Cancer Therapy
Frontiers in Pharmacology, 2019 Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiquitin and protects substrate protein from degradation.
Zhiru Wang +15 more
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The roles of protein ubiquitination in tumorigenesis and targeted drug discovery in lung cancer
Frontiers in Endocrinology, 2023 The malignant lung cancer has a high morbidity rate and very poor 5-year survival rate. About 80% - 90% of protein degradation in human cells is occurred through the ubiquitination enzyme pathway.
Zhen Ye +4 more
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Emerging role of deubiquitination modifications of programmed death-ligand 1 in cancer immunotherapy
Frontiers in Immunology, 2023 Immune evasion is essential for carcinogenesis and cancer progression. Programmed death-ligand 1 (PD-L1), a critical immune checkpoint molecule, interacts with programmed death receptor-1 (PD-1) on immune cells to suppress anti-tumor immune responses. In
Yao Jiang +5 more
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Fundamental ResearchPost-transcriptional epigenetic modifications provide numerous implications for tumor progression, metastasis and recurrence, which also pose resistances to reactive oxygen species (ROS)-based anti-tumor.
Yan Zhang +12 more
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A plague of deubiquitination [PDF]
The Journal of Experimental Medicine, 2005 Plague bacteria inject infected host cells with a ubiquitin-chopping enzyme, according to Zhou and colleagues in a study on [page 1327][1]. The group shows that the virulence factor YopJ operates as a deubiquitinase to shut down multiple signaling pathways that would otherwise help trigger ...
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USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination
Frontiers in Genetics, 2020 Snail is a prominent epithelial–mesenchymal transition (EMT) transcription factor and promotes metastasis. However, Snail protein is unstable and is quickly degraded through ubiquitination-mediated proteasome pathway.
Jiali Cai +10 more
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The role of deubiquitinating enzymes in spermatogenesis
Cellular and Molecular Life Sciences, 2015 Spermatogenesis is a complex process through which spermatogonial stem cells undergo mitosis, meiosis, and cell differentiation to generate mature spermatozoa. During this process, male germ cells experience several translational modifications. One of the major post-translational modifications in eukaryotes is the ubiquitination of proteins, which ...
Bharathi, Suresh +4 more
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Deubiquitinating Enzymes and Bone Remodeling [PDF]
Stem Cells International, 2018 Bone remodeling, which is essential for bone homeostasis, is controlled by multiple factors and mechanisms. In the past few years, studies have emphasized the role of the ubiquitin-dependent proteolysis system in regulating bone remodeling. Deubiquitinases, which are grouped into five families, remove ubiquitin from target proteins and are involved in ...
Yu-chen Guo, Shi-wen Zhang, Quan Yuan
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