Results 31 to 40 of about 22,435 (241)
Histone Deubiquitination Assay in Nicotiana benthamiana
, 2018 Histone modifications are a group of post-translational modifications on histones which can alter chromatin structure and affect gene expression. Histone ubiquitination is a histone modification found in particular on histone H2A and H2B.
Sveriges lantbruksuniversitet. +2 more
core +2 more sources
The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming [PDF]
, 2016 Ubiquitination of core stem cell transcription factors can directly affect stem cell maintenance and differentiation. Ubiquitination and deubiquitination must occur in a timely and well-coordinated manner to regulate the protein turnover of several ...
이준원
core +3 more sources
TRIM25 facilitates mitochondrial dysfunction and extracellular matrix degradation by enhancing USP7-driven ENO1 deubiquitination during intervertebral disc degeneration. [PDF]
Clin Transl MedUnder conditions of low TRIM25 expression, the ubiquitination fate of ENO1 shifts to K48‐linked ubiquitination and degradation. TRIM25 enhances the deubiquitination of ENO1 by recruiting USP7, effectively inhibiting its proteasomal degradation and significantly increasing ENO1 stabilization.
Liu X +10 more
europepmc +2 more sources
Navigating the Deubiquitinating Proteome with a ComPASS [PDF]
Cell, 2009 Deubiquitinating enzymes (DUBs) act on ubiquitinated substrates to regulate their modification and stability. In this issue, Sowa et al. (2009) present a comprehensive proteomic analysis of DUB interacting proteins in humans and a new quantitative scoring system for hits (CompPASS), providing a resource that links DUBs to biological pathways.
openaire +3 more sources
Deubiquitinating Enzymes and Bone Remodeling [PDF]
Stem Cells International, 2018 Bone remodeling, which is essential for bone homeostasis, is controlled by multiple factors and mechanisms. In the past few years, studies have emphasized the role of the ubiquitin-dependent proteolysis system in regulating bone remodeling. Deubiquitinases, which are grouped into five families, remove ubiquitin from target proteins and are involved in ...
Yu-chen Guo, Shi-wen Zhang, Quan Yuan
openaire +3 more sources
Deubiquitination and Activation of AMPK by USP10 [PDF]
Molecular Cell, 2016 The AMP-activated protein kinase (AMPK) is the master regulator of metabolic homeostasis by sensing cellular energy status. When intracellular ATP levels decrease during energy stress, AMPK is initially activated through AMP or ADP binding and phosphorylation of a threonine residue (Thr-172) within the activation loop of its kinase domain.
Deng, Min +11 more
openaire +2 more sources
Deciphering histone 2A deubiquitination [PDF]
Genome Biology, 2008 Three recent papers have identified distinct enzymes that can remove ubiquitin from mammalian histone 2A (H2A). Functions in transcriptional activation, DNA repair and control of the cell cycle have been proposed for these enzymes.
Michael J, Clague +2 more
openaire +2 more sources
eLife, 2020 Protein ubiquitination is a very diverse post-translational modification leading to protein degradation or delocalization, or altering protein activity. In Arabidopsis thaliana, two E3 ligases, BIG BROTHER (BB) and DA2, activate the latent peptidases DA1,
Hannes Vanhaeren +10 more
doaj +1 more source
Nature Communications, 2019 In the Fanconi anemia pathway, deubiquitination of FANCD2 is a fundamental regulatory step. Here, the authors have developed a set of biochemical tools to reconstitute FANCD2 deubiquitination by recombinant USP1-UAF1-RAD51AP1 and reveal critical ...
Fengshan Liang +9 more
doaj +1 more source
USP7: Novel Drug Target in Cancer Therapy
Frontiers in Pharmacology, 2019 Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiquitin and protects substrate protein from degradation.
Zhiru Wang +15 more
doaj +1 more source