Results 51 to 60 of about 28,234 (247)

A new map to understand deubiquitination

Biochemical Society Transactions, 2010
Deubiquitination is a crucial mechanism in ubiquitin-mediated signalling networks. The importance of Dubs (deubiquitinating enzymes) as regulators of diverse cellular processes is becoming ever clearer as new roles are elucidated and new pathways are shown to be affected by this mechanism.
Katz, Elijah J., Isasa, Marta, Crosas, Bernat   +2 more
openaire   +3 more sources

VHL protein‐interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF‐1α [PDF]

EMBO reports, 2005
Hypoxia‐inducible factor (HIF)‐1α is a short‐lived protein and is ubiquitinated and degraded through the von Hippel–Lindau protein (pVHL)–E3 ubiquitin ligase pathway at normoxia. Deubiquitination, by reversing ubiquitination, has been recognized as an important regulatory step in ubiquitination‐related processes.
Zaibo, Li, Dakun, Wang, Edward M, Messing, Guan, Wu   +3 more
openaire   +2 more sources

The role of USP36 in ribosome biogenesis and other pathophysiological processes

Frontiers in Molecular Biosciences
Ubiquitination and deubiquitination are common forms of protein post-translational modifications that play crucial roles in the regulation of intracellular homeostasis.
Linxin Shao, Mengqi Guo, Qianrui Kou, Ya Guo, Xin Li, Fang Li   +5 more
doaj   +1 more source

Role of ubiquitin specific proteases in the immune microenvironment of prostate cancer: A new direction

Frontiers in Oncology, 2022
Regulation of ubiquitination is associated with multiple processes of tumorigenesis and development, including regulation of the tumor immune microenvironment.
Jinhui Guo, Jinhui Guo, Jie Zhao, Litao Sun, Chen Yang   +4 more
doaj   +1 more source

Opposite effects of two zinc(II) dithiocarbamates on NF-kB pathway [PDF]

Inhibiting nuclear factor-kappaB (NF-kB) activation in anticancer and antiinflammatory therapy is of topical interest. Current research in molecular biology has dramatically advanced in the understanding of the cellular events involved in NF-kB induction.
Boris Cvek, Jan Taraba, Jitka Ulrichova, Lukas Muller, Radim Vrzal, Zdenek Dvorak   +5 more
core   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Cellular functions and molecular mechanisms of ubiquitination in osteosarcoma

Frontiers in Oncology, 2022
Although some advances have been made in the treatment of osteosarcoma in recent years, surgical resection remains the mainstream treatment. Initial and early diagnosis of osteosarcoma could be very difficult to achieve due to the insufficient ...
Jiaxun Song, Xiaofeng Yuan, Lianhua Piao, Jiawen Wang, Pu Wang, Ming Zhuang, Jie Liu, Zhiwei Liu, Zhiwei Liu   +8 more
doaj   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Epidermal Growth Factor‐Like Repeats and Discoidin I‐Like Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Dilated cardiomyopathy (DCM) is the leading cause of heart failure with a poor prognosis. Recent studies suggest that endothelial to mesenchymal transition (EndMT) may be involved in the pathogenesis and cardiac remodeling during DCM ...
Mengmeng Zhao, Zihui Zheng, Shanshan Peng, Yao Xu, Jishou Zhang, Jianfang Liu, Wei Pan, Zheng Yin, Shuwan Xu, Cheng Wei, Menglong Wang, Jun Wan, Juan‐Juan Qin   +12 more
doaj   +1 more source

USP14 regulates cell cycle progression through deubiquitinating CDK1 in breast cancer

Acta Biochimica et Biophysica Sinica, 2022
Abnormal proliferation and cell cycle perturbation are the main hallmarks of breast cancer. Cyclin-dependent kinase 1 (CDK1) is one of the key kinases for cell transition from the G2 phase to M phase during the cell cycle progression.
Liu Yuhan, Xu Jing, Wang Yanan, Gan Mingxi, Hu Qifan, Wang Jianbin, Han Tianyu   +6 more
doaj   +1 more source