Results 51 to 60 of about 22,435 (241)
The role of deubiquitinating enzymes in spermatogenesis
Cellular and Molecular Life Sciences, 2015 Spermatogenesis is a complex process through which spermatogonial stem cells undergo mitosis, meiosis, and cell differentiation to generate mature spermatozoa. During this process, male germ cells experience several translational modifications. One of the major post-translational modifications in eukaryotes is the ubiquitination of proteins, which ...
Bharathi, Suresh +4 more
openaire +3 more sources
Acta Pharmaceutica Sinica B, 2023 Deubiquitinating enzymes (DUBs) or deubiquitinases facilitate the escape of multiple proteins from ubiquitin‒proteasome degradation and are critical for regulating protein expression levels in vivo. Therefore, dissecting the underlying mechanism of DUB recognition is needed to advance the development of drugs related to DUB signaling pathways. To data,
Yi-Zheng Fang +4 more
openaire +3 more sources
Endocytosis: Why not wait to deubiquitinate? [PDF]
Current Biology, 2000 Deubiquitination by the Fat facets protein - a regulator of photoreceptor differentiation during Drosophila eye development - has been found to activate endocytosis, while ubiquitination inhibits endocytosis. Surprisingly, this is the opposite effect that ubiquitination has on endocytosis of many plasma membrane proteins.
Carthew, Richard W., Xu, Chunyan
openaire +2 more sources
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Microbiology Spectrum, 2023 The Aedes aegypti mosquito transmits devastating flaviviruses, such as Zika, dengue, and yellow fever viruses. For more effective control of the vector, the pathogenicity of Beauveria bassiana, a fungus commonly used for biological control of pest ...
Yanhong Wang +6 more
doaj +1 more source
Working model for activation of BRIT1 deubiquitination by BRUCE UBC.
, 2015 Following exposure to IR, the E2/E3 activity of BRUCE increases and catalyzes ubiquitination of its substrate(s), yet to be identified, towards deubiquitination of BRIT1 and enhancement of DNA repair.
Chunmin Ge (838812) +2 more
core +1 more source
Advanced Science, EarlyView.. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li +15 more
wiley +1 more source
The role of USP36 in ribosome biogenesis and other pathophysiological processes
Frontiers in Molecular BiosciencesUbiquitination and deubiquitination are common forms of protein post-translational modifications that play crucial roles in the regulation of intracellular homeostasis.
Linxin Shao +5 more
doaj +1 more source
Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers
, 2020 The Wnt signaling pathway plays important roles in embryonic development, homeostatic processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β-catenin binding of Wnt target genes.
Hong-Beom Park +2 more
core +1 more source
TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes
Advanced Science, EarlyView.In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang +11 more
wiley +1 more source