Results 61 to 70 of about 22,435 (241)

Role of ubiquitin specific proteases in the immune microenvironment of prostate cancer: A new direction

Frontiers in Oncology, 2022
Regulation of ubiquitination is associated with multiple processes of tumorigenesis and development, including regulation of the tumor immune microenvironment.
Jinhui Guo, Jinhui Guo, Jie Zhao, Litao Sun, Chen Yang   +4 more
doaj   +1 more source

VHL protein‐interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF‐1α [PDF]

The EMBO Reports, 2005
Hypoxia-inducible factor (HIF)-1alpha is a short-lived protein and is ubiquitinated and degraded through the von Hippel-Lindau protein (pVHL)-E3 ubiquitin ligase pathway at normoxia. Deubiquitination, by reversing ubiquitination, has been recognized as an important regulatory step in ubiquitination-related processes. Here, we show that pVHL-interacting
Zaibo, Li, Dakun, Wang, Edward M, Messing, Guan, Wu   +3 more
openaire   +2 more sources

The Tightly Controlled Deubiquitination Activity of the Human SAGA Complex Differentially Modifies Distinct Gene Regulatory Elements. Molecular and Cellular Biology 31

, 2011
The multisubunit SAGA coactivator complex facilitates access of general transcription factors to DNA through histone acetylation mediated by GCN5. USP22 (ubiquitin-specific protease 22) was recently described as a subunit of the human SAGA complex that ...
Didier Devys, Devys, Didier, Jacques Bonnet, Lang, Guillaume, Jennifer Koffler, Umlauf, David, Bonnet, Jacques, László Tora, David Umlauf, Karmodiya, Krishanpal, Tora, László, Matthieu Stierle, Krishanpal Karmodiya, Koffler, Jennifer, Stierle, Matthieu, Guillaume Lang   +15 more
core   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Epidermal Growth Factor‐Like Repeats and Discoidin I‐Like Domains 3 Deficiency Attenuates Dilated Cardiomyopathy by Inhibiting Ubiquitin Specific Peptidase 10 Dependent Smad4 Deubiquitination

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Dilated cardiomyopathy (DCM) is the leading cause of heart failure with a poor prognosis. Recent studies suggest that endothelial to mesenchymal transition (EndMT) may be involved in the pathogenesis and cardiac remodeling during DCM ...
Mengmeng Zhao, Zihui Zheng, Shanshan Peng, Yao Xu, Jishou Zhang, Jianfang Liu, Wei Pan, Zheng Yin, Shuwan Xu, Cheng Wei, Menglong Wang, Jun Wan, Juan‐Juan Qin   +12 more
doaj   +1 more source

Cellular functions and molecular mechanisms of ubiquitination in osteosarcoma

Frontiers in Oncology, 2022
Although some advances have been made in the treatment of osteosarcoma in recent years, surgical resection remains the mainstream treatment. Initial and early diagnosis of osteosarcoma could be very difficult to achieve due to the insufficient ...
Jiaxun Song, Xiaofeng Yuan, Lianhua Piao, Jiawen Wang, Pu Wang, Ming Zhuang, Jie Liu, Zhiwei Liu, Zhiwei Liu   +8 more
doaj   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Ectopic USP15 expression inhibits HIV-1 transcription involving changes in YY1 deubiquitination and stability

Frontiers in Cellular and Infection Microbiology
IntroductionProtein homeostasis is maintained by the opposing action of ubiquitin ligase and deubiquitinase, two important components of the ubiquitin-proteasome pathway, and contributes to both normal physiological and pathophysiological processes.
Sahar Rezaei, Sahar Rezaei, Sahar Rezaei, Khalid A. Timani, Khalid A. Timani, Khalid A. Timani, Ying Liu, Ying Liu, Ying Liu, Johnny J. He, Johnny J. He, Johnny J. He   +11 more
doaj   +1 more source

Deubiquitinase DUB3 Regulates Cell Cycle Progression via Stabilizing Cyclin A for Proliferation of Non-Small Cell Lung Cancer Cells

Cells, 2019
The deubiquitinase DUB3 is frequently overexpressed in non-small cell lung cancer (NSCLC) and contributes to its malignant phenotype. However, the underlying molecular mechanism of DUB3 in NSCLC is largely unknown.
Bin Hu, Tanggang Deng, Hongchang Ma, Yan Liu, Peifu Feng, Dong Wei, Neng Ling, Ling Li, Siyuan Qiu, Lin Zhang, Bo Peng, Jing Liu, Mao Ye   +12 more
doaj   +1 more source

USP14 regulates cell cycle progression through deubiquitinating CDK1 in breast cancer

Acta Biochimica et Biophysica Sinica, 2022
Abnormal proliferation and cell cycle perturbation are the main hallmarks of breast cancer. Cyclin-dependent kinase 1 (CDK1) is one of the key kinases for cell transition from the G2 phase to M phase during the cell cycle progression.
Liu Yuhan, Xu Jing, Wang Yanan, Gan Mingxi, Hu Qifan, Wang Jianbin, Han Tianyu   +6 more
doaj   +1 more source