Results 61 to 70 of about 20,666 (164)

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication

eLife, 2019
The antiviral activity of host factor apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G (APOBEC3G, A3G) and its degradation mediated by human immunodeficiency virus type 1 (HIV-1) Vif protein are important topics.
Ting Pan, Zheng Song, Liyang Wu, Guangyan Liu, Xiancai Ma, Zhilin Peng, Mo Zhou, Liting Liang, Bingfeng Liu, Jun Liu, Junsong Zhang, Xuanhong Zhang, Ryan Huang, Jiacong Zhao, Yonghong Li, Xuemei Ling, Yuewen Luo, Xiaoping Tang, Weiping Cai, Kai Deng, Linghua Li, Hui Zhang   +21 more
doaj   +1 more source

YTHDF2 in hepatocellular carcinoma: Bridging m6A modification and cancer progression

VIEW, EarlyView.
Abstract YTH N6‐methyladenosine RNAbinding protein F2 (YTHDF2) is an N6‐methyladenosine (m6A) reader protein that mainly regulates the stability of methylated transcripts through mRNA decay. In the liver, YTHDF2 is involved in metabolic homeostasis, oxidative stress responses, and immune regulation.
Sijie Zang, Dongxue Ge, Wanqi Yang, Haobin Shen, Weihong Ge, Li Li, Dayu Chen, Jinglin Wang   +7 more
wiley   +1 more source

USP13 regulates ferroptosis in chicken follicle granulosa cells by deubiquitinating ATG7

Poultry Science
: The development and maturation of follicles are intricately linked to egg production and reproductive performance of chickens. Granulosa cells death directly affects the development and maturation of follicles, thereby impacting the reproductive ...
Shunshun Han, Chunlin Yu, Mohan Qiu, Xia Xiong, Han Peng, Xiaoyan Song, Chenming Hu, Zengrong Zhang, Bo Xia, Li Yang, Jialei Chen, Shiliang Zhu, Wen Li, Chaowu Yang   +13 more
doaj   +1 more source

PABPC1 in Cancer: From a Translational Housekeeper to a Stress‐Responsive Regulatory Hub

Cancer Science, EarlyView.
PABPC1 shifts from a translational housekeeper to a stress‐responsive oncogenic hub via phase separation, PTMs, and non‐coding RNA crosstalk, selectively driving oncogene translation and therapy resistance in cancer. ABSTRACT PABPC1, long recognized as a constitutive translational housekeeper, has emerged as a stress‐responsive translational ...
Cuiwei Zhang, Ye Zhu, Wenbo Long
wiley   +1 more source

An insight into the roles of ubiquitin-specific proteases in plants: development and growth, morphogenesis, and stress response

Frontiers in Plant Science
Ubiquitination is a highly conserved and dynamic post-translational modification in which protein substrates are modified by ubiquitin to influence their activity, localization, or stability. Deubiquitination enzymes (DUBs) counter ubiquitin signaling by
Xiuwen Wang, Xiuwen Wang, Xuan Liu, Xuan Liu, Kaixuan Song, Kaixuan Song, Liang Du, Liang Du   +7 more
doaj   +1 more source

Reactive oxygen species, antioxidants and the regulation of plant development

The FEBS Journal, EarlyView.
The regulation of axillary bud outgrowth by the interplay between phytohormone and redox signals. Axillary bud outgrowth is regulated by cellular energy status and the balance between phytohormones, notably abscisic acid (ABA) and gibberellic acid (GA).
Juwita R. Dewi, Christine H. Foyer, Michael J. Considine   +2 more
wiley   +1 more source

RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms

The FEBS Journal, EarlyView.
RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon, Kyra Swildens, Vera M. Kalscheuer, Cristina Gontan, Francisco Bustos   +4 more
wiley   +1 more source

NMB promotes the progression of colorectal cancer by regulating the NF-κB/P65 signaling pathway

Frontiers in Immunology
BackgroundColorectal carcinoma (CRC) ranks as the fourth most prevalent malignancy globally. Neuromedin B (NMB) and its corresponding receptor have been implicated in the pathogenesis of multiple neoplastic conditions.
Jiaxin Fan, Jiaxin Fan, Yuming Liu, Jiajia Wang, Tian Yao, Shaoxiong Bai, Xiaole Ma, Hao Chen, Yuhao Chen, Huiyang Gao, Yuntong Guo, He Huang   +11 more
doaj   +1 more source

The role of ubiquitination and deubiquitination in the regulation of cell junctions

Protein & Cell, 2017
Maintenance of cell junctions plays a crucial role in the regulation of cellular functions including cell proliferation, permeability, and cell death.
Junting Cai, Miranda K. Culley, Yutong Zhao, Jing Zhao   +3 more
doaj   +1 more source