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Protein stability: a crystallographer's perspective [PDF]
Acta Crystallographica Section F, Structural Biology Communications, 2016 Protein stability is a topic of major interest for the biotechnology, pharmaceutical and food industries, in addition to being a daily consideration for academic researchers studying proteins. An understanding of protein stability is essential for optimizing the expression, purification, formulation, storage and structural studies of proteins.
Marc C Deller +2 more
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Performance of protein stability predictors [PDF]
Human Mutation, 2010 Stability is a fundamental property affecting function, activity, and regulation of biomolecules. Stability changes are often found for mutated proteins involved in diseases. Stability predictors computationally predict protein-stability changes caused by mutations.
Sofia Khan, Mauno Vihinen
exaly +4 more sources
Molecular Oncology, 2022 Oncogenic transformation of lung epithelial cells is a multistep process, frequently starting with the inactivation of tumour suppressors and subsequent development of activating mutations in proto‐oncogenes, such as members of the PI3K or MAPK families.
Cristian Prieto‐Garcia +14 more
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USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell Carcinoma
Cells, 2021 Squamous cell carcinomas are therapeutically challenging tumor entities. Low response rates to radiotherapy and chemotherapy are commonly observed in squamous patients and, accordingly, the mortality rate is relatively high compared to other tumor ...
Cristian Prieto-Garcia +4 more
doaj +1 more source
Protein Stability in Ice [PDF]
Biophysical Journal, 2007 This study presents an experimental approach, based on the change of Trp fluorescence between native and denatured states of proteins, which permits to monitor unfolding equilibria and the thermodynamic stability (DeltaG degrees ) of these macromolecules in frozen aqueous solutions.
Strambini GB, Gonnelli M
openaire +4 more sources
Cell & Bioscience, 2022 Background Despite advances in treatment of patients with non-small cell lung cancer, carriers of certain genetic alterations are prone to failure. One such factor frequently mutated, is the tumor suppressor PTEN.
Thomas Fischer +16 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Lung cancer is the most common cancer worldwide and the leading cause of cancer-related deaths in both men and women. Despite the development of novel therapeutic interventions, the 5-year survival rate for non-small cell lung cancer (NSCLC) patients ...
Oliver Hartmann +30 more
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Enhancement of The Stability of Human Growth Hormone by Using Tris(hydroxymethyl)aminomethane: Molecular Docking and Experimental Analysis [PDF]
Cell Journal, 2021 Objective: It is so difficult to formulate human growth hormone (hGH) in a solution with high stability and new drug delivery system (NDDs) due to physiochemical instability. The purpose of this study was to investigate the possibility of using Tris as
Siyavash Mirzaei +6 more
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Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes
Nature Communications, 2022 For several decades the MCM2-7 proteins, the core of the DNA replicative helicase, eluded detection at DNA replication sites. Here, the authors solve this conundrum by gene editing, which enables visualization of replication dynamics in living cells.
Hana Polasek-Sedlackova +4 more
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Pharmaceutics, 2020 Clinical symptoms of Alzheimer’s Disease (AD) include behavioral alterations and cognitive impairment. These functional phenotypes early occur in triple-transgenic (3xTg-AD) mice.
Alejandro R. Roda +3 more
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