Results 11 to 20 of about 6,635,393 (306)

Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells

EMBO Molecular Medicine, 2020
The transcription factor ∆Np63 is a master regulator of epithelial cell identity and essential for the survival of squamous cell carcinoma (SCC) of lung, head and neck, oesophagus, cervix and skin. Here, we report that the deubiquitylase USP28 stabilizes
Cristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Thomas Fischer, Susanne Walz, Christina Schülein‐Völk, Ursula Eilers, Carsten P Ade, Marco A Calzado, Amir Orian, Hans M Maric, Christian Münch, Mathias Rosenfeldt, Martin Eilers, Markus E Diefenbacher   +15 more
doaj   +1 more source

The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis

Nature Communications, 2022
Heparan sulphate (HS)—a common cell surface decoration—is a carbohydrate of alternating sugars assembled by bi-domain enzymes such as EXTL3. Here, authors present the structure of EXTL3, explain EXTL3 lost activity, and propose that HS extension is ...
L. F. L. Wilson, T. Dendooven, S. W. Hardwick, A. Echevarría-Poza, T. Tryfona, K. B. R. M. Krogh, D. Y. Chirgadze, B. F. Luisi, D. T. Logan, K. Mani, P. Dupree   +10 more
doaj   +1 more source

CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]

, 2018
Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry, Hendershot, Linda M., Feige, Matthias J., Ineke Braakman, Matthias J. Feige, Braakman, Ineke, Cellular Protein Chemistry, Linda M. Hendershot   +7 more
core   +1 more source

Multi-Environmental Evaluation of Protein Content and Yield Stability among Tropical Soybean Genotypes Using GGE Biplot Analysis

Agronomy, 2021
The yield and protein performance in a soybean genotype result from its interaction with the prevailing environmental conditions. This makes selecting the best genotypes under varied target production environments more complex.
Tonny Obua, Julius Pyton Sserumaga, Bruno Awio, Fredrick Nganga, Thomas L. Odong, Phinehas Tukamuhabwa, Geoffrey Tusiime, Settumba B. Mukasa, Margaret Nabasirye   +8 more
doaj   +1 more source

The Effects of SARS CoV-2 nsp13 Mutations on the Structure and Stability of Helicase in Chinese Isolates

European Journal of Biology, 2022
Objective: Coronavirus Disease 2019 (COVID19) is a viral disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2). The high mutation propensity of the SARS CoV-2 genome is one of the biggest threats to the long-term validity of ...
Ekrem Akbulut
doaj   +1 more source

RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival

Cell Death and Disease, 2022
Molecular understanding of osteogenic differentiation (OD) of human bone marrow-derived mesenchymal stem cells (hBMSCs) is important for regenerative medicine and has direct implications for cancer.
Rostislav Novak, Yamen Abu Ahmad, Michael Timaner, Eliya Bitman-Lotan, Avital Oknin-Vaisman, Roi Horwitz, Oliver Hartmann, Michaela Reissland, Viktoria Buck, Mathias Rosenfeldt, David Nikomarov, Markus Elmar Diefenbacher, Yuval Shaked, Amir Orian   +13 more
doaj   +1 more source

Salting the charged surface: pH and salt dependence of protein G B1 stability. [PDF]

, 2006
This study shows significant effects of protein surface charges on stability and these effects are not eliminated by salt screening. The stability for a variant of protein G B1 domain was studied in the pH-range of 1.5-11 at low, 0.15 M, and 2 M salt ...
Xue, Wei-Feng, Linse, Sara,, Bauer, Mikael C., Szczepankiewicz, Olga, Bauer, Mikael,, Lindman, Stina, Wei-Feng Xue, Xue, Wei-Feng,, Nilsson, Hanna,, Szczepankiewicz, Olga,, Stina Lindman, Olga Szczepankiewicz, Mikael C. Bauer, Hanna Nilsson, Lindman, Stina,, Nilsson, Hanna, Bauer, Mikael, Sara Linse, Linse, Sara, Lund University.   +19 more
core   +1 more source

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

eLife, 2019
The faithful segregation of eukaryotic chromosomes in mitosis requires that the genome be duplicated completely prior to anaphase. However, cells with large genomes sometimes fail to complete replication during interphase and instead enter mitosis with ...
Remi Sonneville, Rahul Bhowmick, Saskia Hoffmann, Niels Mailand, Ian D Hickson, Karim Labib   +5 more
doaj   +1 more source

The Impact of Redox, Hydrolysis and Dehydration Chemistry on the Structural and Magnetic Properties of Magnetoferritin Prepared in Variable Thermal Conditions

Molecules, 2021
Ferritin, a spherically shaped protein complex, is responsible for iron storage in bacteria, plants, animals, and humans. Various ferritin iron core compositions in organisms are associated with specific living requirements, health state, and different ...
Lucia Balejčíková, Karel Saksl, Jozef Kováč, Anne Martel, Vasil M. Garamus, Mikhail V. Avdeev, Viktor I. Petrenko, László Almásy, Peter Kopčanský   +8 more
doaj   +1 more source

Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTpp. [PDF]

, 2012
The biophysical stability is an important parameter for protein activity both in vivo and in vitro. Here we propose a method to analyse thermal melting of protein domains in lysates: Fast parallel proteolysis (FASTpp).
Rüdiger, Stefan G. D., Stefan G D Rüdiger, Maurice, Madelon M., David P Minde, Sub Cellular Protein Chemistry, Stefan G. D. Rüdiger, Madelon M Maurice, Minde, David P., Cellular Protein Chemistry, David P. Minde, Madelon M. Maurice   +10 more
core   +3 more sources