Results 11 to 20 of about 1,107,740 (262)

Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication

Cell Reports, 2020
Summary: It has been long assumed that normally leading strand synthesis must proceed coordinated with the lagging strand to prevent strand uncoupling and the pathological accumulation of single-stranded DNA (ssDNA) in the cell, a dogma recently ...
Amaia Ercilla, Jan Benada, Sampath Amitash, Gijs Zonderland, Giorgio Baldi, Kumar Somyajit, Fena Ochs, Vincenzo Costanzo, Jiri Lukas, Luis Toledo   +9 more
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Maintaining protein stability of ∆Np63 via USP28 is required by squamous cancer cells

EMBO Molecular Medicine, 2020
The transcription factor ∆Np63 is a master regulator of epithelial cell identity and essential for the survival of squamous cell carcinoma (SCC) of lung, head and neck, oesophagus, cervix and skin. Here, we report that the deubiquitylase USP28 stabilizes
Cristian Prieto‐Garcia, Oliver Hartmann, Michaela Reissland, Fabian Braun, Thomas Fischer, Susanne Walz, Christina Schülein‐Völk, Ursula Eilers, Carsten P Ade, Marco A Calzado, Amir Orian, Hans M Maric, Christian Münch, Mathias Rosenfeldt, Martin Eilers, Markus E Diefenbacher   +15 more
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The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis

Nature Communications, 2022
Heparan sulphate (HS)—a common cell surface decoration—is a carbohydrate of alternating sugars assembled by bi-domain enzymes such as EXTL3. Here, authors present the structure of EXTL3, explain EXTL3 lost activity, and propose that HS extension is ...
L. F. L. Wilson, T. Dendooven, S. W. Hardwick, A. Echevarría-Poza, T. Tryfona, K. B. R. M. Krogh, D. Y. Chirgadze, B. F. Luisi, D. T. Logan, K. Mani, P. Dupree   +10 more
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Multi-Environmental Evaluation of Protein Content and Yield Stability among Tropical Soybean Genotypes Using GGE Biplot Analysis

Agronomy, 2021
The yield and protein performance in a soybean genotype result from its interaction with the prevailing environmental conditions. This makes selecting the best genotypes under varied target production environments more complex.
Tonny Obua, Julius Pyton Sserumaga, Bruno Awio, Fredrick Nganga, Thomas L. Odong, Phinehas Tukamuhabwa, Geoffrey Tusiime, Settumba B. Mukasa, Margaret Nabasirye   +8 more
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The Effects of SARS CoV-2 nsp13 Mutations on the Structure and Stability of Helicase in Chinese Isolates

European Journal of Biology, 2022
Objective: Coronavirus Disease 2019 (COVID19) is a viral disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2). The high mutation propensity of the SARS CoV-2 genome is one of the biggest threats to the long-term validity of ...
Ekrem Akbulut
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RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival

Cell Death and Disease, 2022
Molecular understanding of osteogenic differentiation (OD) of human bone marrow-derived mesenchymal stem cells (hBMSCs) is important for regenerative medicine and has direct implications for cancer.
Rostislav Novak, Yamen Abu Ahmad, Michael Timaner, Eliya Bitman-Lotan, Avital Oknin-Vaisman, Roi Horwitz, Oliver Hartmann, Michaela Reissland, Viktoria Buck, Mathias Rosenfeldt, David Nikomarov, Markus Elmar Diefenbacher, Yuval Shaked, Amir Orian   +13 more
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The Impact of Redox, Hydrolysis and Dehydration Chemistry on the Structural and Magnetic Properties of Magnetoferritin Prepared in Variable Thermal Conditions

Molecules, 2021
Ferritin, a spherically shaped protein complex, is responsible for iron storage in bacteria, plants, animals, and humans. Various ferritin iron core compositions in organisms are associated with specific living requirements, health state, and different ...
Lucia Balejčíková, Karel Saksl, Jozef Kováč, Anne Martel, Vasil M. Garamus, Mikhail V. Avdeev, Viktor I. Petrenko, László Almásy, Peter Kopčanský   +8 more
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TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

eLife, 2019
The faithful segregation of eukaryotic chromosomes in mitosis requires that the genome be duplicated completely prior to anaphase. However, cells with large genomes sometimes fail to complete replication during interphase and instead enter mitosis with ...
Remi Sonneville, Rahul Bhowmick, Saskia Hoffmann, Niels Mailand, Ian D Hickson, Karim Labib   +5 more
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Lessons Learned in Protein Precipitation Using a Membrane Emulsification Technique to Produce Reversible and Uniform Microbeads

Pharmaceutics, 2021
The effects of the manufacturing process and the regeneration of Shirasu porous glass (SPG) membranes were investigated on the reproducibility of protein precipitants, termed protein microbeads.
Sang-Koo Park, Ga Yeon Noh, Hyun Woo Yu, Eun Chae Lee, Junoh Jeong, Young-Min Park, Hyo-Kyung Han, Seong Hoon Jeong, Nam Ah Kim   +8 more
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SGK1, a Serine/Threonine Kinase, Inhibits Prototype Foamy Virus Replication

Microbiology Spectrum, 2022
Foamy viruses (FVs) are complex retroviruses belonging to the Spumaretrovirinae subfamily of the Retroviridae family. In contrast to human immunodeficiency virus (HIV), another member of the Retroviridae family, FVs are nonpathogenic in their natural ...
Junshi Zhang, Chunhua Han, Zhenjie Xiong, Manman Qiu, Xiaopeng Tuo, Chenchen Wang, Wentao Qiao, Juan Tan   +7 more
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