Results 31 to 40 of about 6,635,393 (306)
Impaired local hydrophobicity, structural stability and conformational flexibility due to point mutations in SULT1 family of enzymes [PDF]
Journal of the Serbian Chemical Society, 2023 Sulfotransferases (SULTs) are enzymes involved in phase II of the metabolism of xenobiotics. Single nucleotide polymorphisms were identified for genes encoding the SULTs leading to allozymes with modified sulfating activity.
Ceauranu Silvana +2 more
doaj +1 more source
Cells, 2021 The ultimate goal of gene expression regulation is on the protein level. However, because the amounts of mRNAs and proteins are controlled by their synthesis and degradation rates, the cellular amount of a given protein can be attained by following ...
Jaume Forés-Martos +3 more
doaj +1 more source
Statistical Models of the Protein Fitness Landscape: Applications to Protein Evolution and Engineering [PDF]
, 2012 Understanding the protein fitness landscape is important for describing how natural proteins evolve and for engineering new proteins with useful properties.
Romero, Philip Anthony
core +1 more source
Protein GB1 folding and assembly from structural elements. [PDF]
, 2009 Folding of the Protein G B1 domain (PGB1) shifts with increasing salt concentration from a cooperative assembly of inherently unstructured subdomains to an assembly of partly pre-folded structures.
Xue, Wei-Feng +6 more
core +1 more source
Pharmaceutics, 2023 Currently deployed SARS-CoV-2 vaccines all require storage at refrigerated or sub-zero temperatures. We demonstrate that after month-long incubation at 37 °C, solubilization, and formulation with squalene-in-water emulsion adjuvant, a stabilized receptor
Mohammad Suhail Khan +9 more
doaj +1 more source
A Computational Model of the LGI1 Protein Suggests a Common Binding Site for ADAM Proteins [PDF]
, 2011 Mutations of human leucine-rich glioma inactivated (LGI1) gene encoding the epitempin protein cause autosomal dominant temporal lateral epilepsy (ADTLE), a rare familial partial epileptic syndrome.
Leonardi, Emanuela +23 more
core +1 more source
Biotechnology for Biofuels, 2017 Background Plant lignocellulosic biomass can be a source of fermentable sugars for the production of second generation biofuels and biochemicals. The recalcitrance of this plant material is one of the major obstacles in its conversion into sugars ...
Jan J. Lyczakowski +8 more
doaj +1 more source
Biomolecules, 2021 Signal amplification in biomolecular networks converts a linear input to a steeply sigmoid output and is central to a number of cellular functions including proliferation, differentiation, homeostasis, adaptation, and biological rhythms.
Carla M. Kumbale +2 more
doaj +1 more source
Development and Validation of Optimization Methods for the Design of Protein Sequences and Combinatorial Libraries [PDF]
, 2009 To facilitate the design of protein sequences with desired properties, simulation techniques have been developed to allow large portions of amino acid sequence space to be evaluated by computer.
Allen, Benjamin Daniel
core +1 more source
4D Visualization of replication foci in mammalian cells corresponding to individual replicons
Nature Communications, 2016 Whether replication happens at individual replicons or in replication factories is a controversial debate. Here the authors use super-resolution microscopy and analysis of replication fork speed to present evidence in favour of replicons.
V. O. Chagin +12 more
doaj +1 more source