Results 31 to 40 of about 1,107,740 (262)
Biomolecules, 2021 Signal amplification in biomolecular networks converts a linear input to a steeply sigmoid output and is central to a number of cellular functions including proliferation, differentiation, homeostasis, adaptation, and biological rhythms.
Carla M. Kumbale +2 more
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Foods, 2021 In this work, the effect of pre-fermentative skin maceration (PFSM) on the chemical composition of the macromolecular fraction, polysaccharides and proteins, phenolic compounds, chromatic characteristics, and protein stability of Albariño monovarietal ...
Inma Arenas +7 more
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4D Visualization of replication foci in mammalian cells corresponding to individual replicons
Nature Communications, 2016 Whether replication happens at individual replicons or in replication factories is a controversial debate. Here the authors use super-resolution microscopy and analysis of replication fork speed to present evidence in favour of replicons.
V. O. Chagin +12 more
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Biomolecules, 2019 Methylation is a widespread modification occurring in DNA, RNA and proteins. The N6AMT1 (HEMK2) protein has DNA N6-methyladenine as well as the protein glutamine and histone lysine methyltransferase activities.
Lilian Leetsi +3 more
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Cross-Talk between Overlap Interactions in Biomolecules: A Case Study of the β-Turn Motif
Molecules, 2021 Noncovalent interactions play a pivotal role in regulating protein conformation, stability and dynamics. Among the quantum mechanical (QM) overlap-based noncovalent interactions, n→π* is the best understood with studies ranging from small molecules to β ...
Jayashree Nagesh
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The Stabilities of Protein Crystals [PDF]
The Journal of Physical Chemistry B, 2010 We describe a model for protein crystallization equilibria. The model includes four terms, (1) protein translational entropy opposes crystallization, (2) proteins are attracted to each other by a nonelectrostatic contact free energy favoring crystallization, (3) proteins in the crystal repel each other but, to a greater extent, attract counterions ...
Jeremy D, Schmit, Ken A, Dill
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Molecular Context-Dependent Effects Induced by Rett Syndrome-Associated Mutations in MeCP2
Biomolecules, 2020 Methyl-CpG binding protein 2 (MeCP2) is a transcriptional regulator and a chromatin-binding protein involved in neuronal development and maturation. Loss-of-function mutations in MeCP2 result in Rett syndrome (RTT), a neurodevelopmental disorder that is ...
David Ortega-Alarcon +6 more
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Influence of Subcellular Localization and Functional State on Protein Turnover
Cells, 2021 Protein homeostasis is an equilibrium of paramount importance that maintains cellular performance by preserving an efficient proteome. This equilibrium avoids the accumulation of potentially toxic proteins, which could lead to cellular stress and death ...
Roya Yousefi +4 more
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The Impact of Glycerol on an Affibody Conformation and Its Correlation to Chemical Degradation
Pharmaceutics, 2021 The addition of glycerol to protein solutions is often used to hinder the aggregation and denaturation of proteins. However, it is not a generalised practice against chemical degradation reactions.
Ingrid Ramm +7 more
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The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli +3 more
wiley +1 more source