Results 21 to 30 of about 1,107,740 (262)

Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

eLife, 2019
Defective mismatch repair leads to increased mutation rates, and germline loss-of-function variants in the repair component MLH1 cause the hereditary cancer predisposition disorder known as Lynch syndrome. Early diagnosis is important, but complicated by
Amanda B Abildgaard, Amelie Stein, Sofie V Nielsen, Katrine Schultz-Knudsen, Elena Papaleo, Amruta Shrikhande, Eva R Hoffmann, Inge Bernstein, Anne-Marie Gerdes, Masanobu Takahashi, Chikashi Ishioka, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen   +12 more
doaj   +1 more source

DCMC as a Promising Alternative to Bentonite in White Wine Stabilization. Impact on Protein Stability and Wine Aromatic Fraction

Molecules, 2021
Protein haze in white wine is one of the most common non-microbial defects of commercial wines, with bentonite being the main solution utilized by the winemaking industry to tackle this problem.
Francesco Saracino, João Brinco, Diana Gago, Marco Gomes da Silva, Ricardo Boavida Ferreira, Jorge Ricardo-da-Silva, Ricardo Chagas, Luísa Maria Ferreira   +7 more
doaj   +1 more source

Acetylation of a fungal effector that translocates host PR1 facilitates virulence

eLife, 2022
Pathogens utilize a panoply of effectors to manipulate plant defense. However, despite their importance, relatively little is actually known about regulation of these virulence factors.
Jingtao Li, Xiaoying Ma, Chenyang Wang, Sihui Liu, Gang Yu, Mingming Gao, Hengwei Qian, Mengjie Liu, Ben F Luisi, Dean W Gabriel, Wenxing Liang   +10 more
doaj   +1 more source

Evaluation of AlphaFold structure-based protein stability prediction on missense variations in cancer

Frontiers in Genetics, 2023
Identifying pathogenic missense variants in hereditary cancer is critical to the efforts of patient surveillance and risk-reduction strategies. For this purpose, many different gene panels consisting of different number and/or set of genes are available ...
Hilal Keskin Karakoyun, Şirin K. Yüksel, Ilayda Amanoglu, Lara Naserikhojasteh, Ahmet Yeşilyurt, Cengiz Yakıcıer, Emel Timuçin, Cemaliye B. Akyerli   +7 more
doaj   +1 more source

Impaired local hydrophobicity, structural stability and conformational flexibility due to point mutations in SULT1 family of enzymes [PDF]

Journal of the Serbian Chemical Society, 2023
Sulfotransferases (SULTs) are enzymes involved in phase II of the metabolism of xenobiotics. Single nucleotide polymorphisms were identified for genes encoding the SULTs leading to allozymes with modified sulfating activity.
Ceauranu Silvana, Ostafe Vasile, Isvoran Adriana   +2 more
doaj   +1 more source

Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress

Cell Reports, 2017
Summary: The mechanisms that protect eukaryotic DNA during the cumbersome task of replication depend on the precise coordination of several post-translational modification (PTM)-based signaling networks.
Stephanie Munk, Jón Otti Sigurðsson, Zhenyu Xiao, Tanveer Singh Batth, Giulia Franciosa, Louise von Stechow, Andres Joaquin Lopez-Contreras, Alfred Cornelis Otto Vertegaal, Jesper Velgaard Olsen   +8 more
doaj   +1 more source

A Trans-Omics Comparison Reveals Common Gene Expression Strategies in Four Model Organisms and Exposes Similarities and Differences between Them

Cells, 2021
The ultimate goal of gene expression regulation is on the protein level. However, because the amounts of mRNAs and proteins are controlled by their synthesis and degradation rates, the cellular amount of a given protein can be attained by following ...
Jaume Forés-Martos, Anabel Forte, José García-Martínez, José E. Pérez-Ortín   +3 more
doaj   +1 more source

Forces stabilizing proteins [PDF]

FEBS Letters, 2014
The goal of this article is to summarize what has been learned about the major forces stabilizing proteins since the late 1980s when site‐directed mutagenesis became possible. The following conclusions are derived from experimental studies of hydrophobic and hydrogen bonding variants.
Nick Pace, C., Scholtz, J. Martin, Grimsley, Gerald R.   +2 more
openaire   +2 more sources

Enhancing Immunogenicity of a Thermostable, Efficacious SARS-CoV-2 Vaccine Formulation through Oligomerization and Adjuvant Choice

Pharmaceutics, 2023
Currently deployed SARS-CoV-2 vaccines all require storage at refrigerated or sub-zero temperatures. We demonstrate that after month-long incubation at 37 °C, solubilization, and formulation with squalene-in-water emulsion adjuvant, a stabilized receptor
Mohammad Suhail Khan, Virginie Jakob, Randhir Singh, Raju S. Rajmani, Sahil Kumar, Céline Lemoine, Harry Kleanthous, Rajesh P. Ringe, Patrice M. Dubois, Raghavan Varadarajan   +9 more
doaj   +1 more source

Removal of glucuronic acid from xylan is a strategy to improve the conversion of plant biomass to sugars for bioenergy

Biotechnology for Biofuels, 2017
Background Plant lignocellulosic biomass can be a source of fermentable sugars for the production of second generation biofuels and biochemicals. The recalcitrance of this plant material is one of the major obstacles in its conversion into sugars ...
Jan J. Lyczakowski, Krzysztof B. Wicher, Oliver M. Terrett, Nuno Faria-Blanc, Xiaolan Yu, David Brown, Kristian B. R. M. Krogh, Paul Dupree, Marta Busse-Wicher   +8 more
doaj   +1 more source