Results 21 to 30 of about 6,635,393 (306)

Lessons Learned in Protein Precipitation Using a Membrane Emulsification Technique to Produce Reversible and Uniform Microbeads

open access: yesPharmaceutics, 2021
The effects of the manufacturing process and the regeneration of Shirasu porous glass (SPG) membranes were investigated on the reproducibility of protein precipitants, termed protein microbeads.
Sang-Koo Park   +8 more
doaj   +1 more source

Non-Contiguous Protein Recombination [PDF]

open access: yes, 2013
Swapping sequence elements among related proteins can produce chimeric proteins with novel behaviors and improved properties such as enhanced stability. Although homologous mutations are much more conservative than random mutations, chimeras of distantly-
Smith, Matthew Alexander
core   +1 more source

Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

open access: yeseLife, 2019
Defective mismatch repair leads to increased mutation rates, and germline loss-of-function variants in the repair component MLH1 cause the hereditary cancer predisposition disorder known as Lynch syndrome. Early diagnosis is important, but complicated by
Amanda B Abildgaard   +12 more
doaj   +1 more source

SGK1, a Serine/Threonine Kinase, Inhibits Prototype Foamy Virus Replication

open access: yesMicrobiology Spectrum, 2022
Foamy viruses (FVs) are complex retroviruses belonging to the Spumaretrovirinae subfamily of the Retroviridae family. In contrast to human immunodeficiency virus (HIV), another member of the Retroviridae family, FVs are nonpathogenic in their natural ...
Junshi Zhang   +7 more
doaj   +1 more source

Studying protein-protein interactions using peptide arrays [PDF]

open access: yes, 2010
Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T.   +7 more
core   +1 more source

DCMC as a Promising Alternative to Bentonite in White Wine Stabilization. Impact on Protein Stability and Wine Aromatic Fraction

open access: yesMolecules, 2021
Protein haze in white wine is one of the most common non-microbial defects of commercial wines, with bentonite being the main solution utilized by the winemaking industry to tackle this problem.
Francesco Saracino   +7 more
doaj   +1 more source

Acetylation of a fungal effector that translocates host PR1 facilitates virulence

open access: yeseLife, 2022
Pathogens utilize a panoply of effectors to manipulate plant defense. However, despite their importance, relatively little is actually known about regulation of these virulence factors.
Jingtao Li   +10 more
doaj   +1 more source

Exploring Protein Sequence Space Using Computationally Directed Recombination [PDF]

open access: yes, 2006
Evolution has provided us with many protein sequences. However, these sequences represent a very small fraction of the possible sequences. In the laboratory, scientists have explored areas of sequence space not represented by natural proteins both to ...
Meyer, Michelle Margaret
core   +1 more source

Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress

open access: yesCell Reports, 2017
Summary: The mechanisms that protect eukaryotic DNA during the cumbersome task of replication depend on the precise coordination of several post-translational modification (PTM)-based signaling networks.
Stephanie Munk   +8 more
doaj   +1 more source

Evaluation of AlphaFold structure-based protein stability prediction on missense variations in cancer

open access: yesFrontiers in Genetics, 2023
Identifying pathogenic missense variants in hereditary cancer is critical to the efforts of patient surveillance and risk-reduction strategies. For this purpose, many different gene panels consisting of different number and/or set of genes are available ...
Hilal Keskin Karakoyun   +7 more
doaj   +1 more source

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