Results 1 to 10 of about 3,826 (176)

Dual Function of USP14 Deubiquitinase in Cellular Proteasomal Activity and Autophagic Flux [PDF]

Cell Reports, 2018
Summary: The ubiquitin-proteasome system and the autophagy-lysosome system are two major intracellular proteolytic pathways in eukaryotes. Although several biochemical mechanisms underlying the crosstalk between them have been suggested, little is known ...
Eunkyoung Kim, Seoyoung Park, Jung Hoon Lee   +2 more
exaly   +5 more sources

Targeting ubiquitin-specific protease 14 reduces metastatic potential and metabolic activity in cervical cancer via direct modulation of monocarboxylate transporter-4 [PDF]

Journal of Translational Medicine
Background Cervical cancer (CC) remains a major health burden in low- and middle-income countries, where HPV vaccination coverage is suboptimal. Ubiquitin-specific peptidase 14 (USP14), a proteasome-associated deubiquitinase, has emerged as a potential ...
Ravi Chauhan, Gunjan Dagar, Lakshay Malhotra, Ashna Gupta, Anju Surendranath, Harshul Kapoor, Hemant Yadav, Rajat Ujjainiya, Suraja Kumar Das, Sameer Mirza, Mukesh Tanwar, Pranay Tanwar, Abdul S. Ethayathulla, Archana Singh, Muzafar A. Macha, Shahab Uddin, Ammira S. Al-Shabeeb Akil, Sandeep Mathur, Tej K. Pandita, Ajaz A. Bhat, Mayank Singh   +20 more
doaj   +2 more sources

USP14 promotes epithelial-mesenchymal transition and functions as a multifaceted biomarker in lung adenocarcinoma [PDF]

Discover Oncology
Ubiquitin-specific protease 14 (USP14) is highly expressed in various tumors and functions as a critical regulator of proteasomal protein degradation.
Chenzhuo Wu, Zhimeng Chen, Jian Yang, Hao Shi, Yuxuan Xing, Haoran Liu, Ziqing Shen, Chun Xu, Cheng Ding, Hao Ding, Jun Zhao   +10 more
doaj   +2 more sources

The deubiquitination enzyme USP14 promotes the tumourigenesis of gastric cancer by enhancing c-MYC nuclear translocation through deubiquitination of KPNA2 [PDF]

Cell Death and Disease
The deubiquitinating enzyme USP14, which belongs to the ubiquitin-specific protease family, is highly expressed in various malignant tumors. The regulatory mechanisms in tumors are complex and diverse, encompassing a range of cellular processes such as ...
Jia Li, Houyi Tang, Hongbo Chang, Yi Du, Liang Du, Erhu Zhao   +5 more
doaj   +2 more sources

Breaking Barriers in Alzheimer’s: Next‐Gen Small Molecules Targeting USP14 for Neuroprotection and Protein Homeostasis [PDF]

Alzheimers Dement
Abstract Background In Alzheimer's disease (AD) brains, autophagy is over activated, however emerging research suggests that the ubiquitin‐proteasome system might clear aggregation proteins and be a therapeutic target for AD and protein misfolding diseases.
Ariyath A, Bharadwaj P, Fernando W, Martins R.   +3 more
europepmc   +2 more sources

USP14 as a novel prognostic marker promotes cisplatin resistance via Akt/ERK signaling pathways in gastric cancer

Cancer Medicine, 2018
Gastric cancer (GC) ranks the third leading cause of global cancer mortality. Despite recent progress in surgery combined with chemotherapy, the outcomes of GC patients have barely improved.
Gang Ma, Guolong Liu, Xishan Hao
exaly   +2 more sources

Targeting USP14 enhances immunotherapy response by reprogramming tumor-associated macrophages in colon cancer [PDF]

iScience
Summary: Combining immunotherapy with other treatments improves survival in colorectal cancer (CRC), yet some patients remain unresponsive. Tumor-associated macrophages (TAMs) are a key immune cell population driving this immunotherapy resistance and ...
Dan Xiao, Jun Fang, Hui Jian, Yang Yu
doaj   +2 more sources

Ubiquitin-specific protease 14 inhibition promotes mitophagy and attenuates neural apoptosis after spinal cord injury [PDF]

Scientific Reports
Spinal cord injury (SCI) is a devastating condition characterized by severe neurological deficits and limited recovery, primarily due to the intricate cascade of secondary injury mechanisms.
Dingwei Wu, Dehui Chen, Huina Chen, Zhengxi Yu, Hao Feng, Linquan Zhou, Zhi Chen, Tengbin Shi, Rongcan Wu, Yelei Zhang, Lei Sun, Zhenyu Wang, Wenge Liu   +12 more
doaj   +2 more sources

USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer [PDF]

Molecular Medicine
Background Mitophagy, essential for cellular homeostasis, is involved in eliminating damaged mitochondria and is associated with cancer progression and chemoresistance.
Zhiyong Wang, Cheng Yu, Gengchen Xie, Kaixiong Tao, Zhijie Yin, Qing Lv   +5 more
doaj   +2 more sources

Targeting the TRIM14/USP14 axis enhances radiotherapy efficacy by inducing GPX4 degradation and disrupting ferroptotic defense in HCC [PDF]

Cell Death and Disease
Radiation resistance constitutes a formidable impediment in the treatment paradigm for hepatocellular carcinoma (HCC). Deubiquitinases (DUBs) exhibit notable efficacy in modulating cellular responses to stress and exogenous interventions, endowed with ...
Xin Yue, Zhen Xiang, Yang Yi, Xuecen Wang, Weilin Zhou, Weijian Wu, Wenjing Qin, Yuxuan Zhao, Xianzhang Bu, Zhenwei Peng   +9 more
doaj   +2 more sources