Structural Dynamics Analysis of USP14 Activation by AKT-Mediated Phosphorylation [PDF]
CellsUbiquitin-specific protease 14 (USP14), one of the three major proteasome-associated deubiquitinating enzymes (DUBs), is known to be activated by the AKT-mediated phosphorylation at Ser432.
Byung-Hoon Lee, Sung Bae Lee, Raju Dash
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Dual Function of USP14 Deubiquitinase in Cellular Proteasomal Activity and Autophagic Flux [PDF]
Cell Reports, 2018 Summary: The ubiquitin-proteasome system and the autophagy-lysosome system are two major intracellular proteolytic pathways in eukaryotes. Although several biochemical mechanisms underlying the crosstalk between them have been suggested, little is known ...
Seoyoung Park, Jeeyoung Lee, Min Jae Lee
exaly +5 more sources
USP14 promotes head and neck squamous cell carcinoma progression via deubiquitinating and stabilizing CFL2 [PDF]
Future Science OAAim To identify novel substrates of USP14 and elucidate the molecular mechanisms by which USP14 promotes head and neck squamous cell carcinoma (HNSCC) progression.Materials and methods USP14 expression patterns were examined in HNSCC tissues and cell ...
Yue Liu +6 more
doaj +2 more sources
Emerging regulatory model of Ubiquitin-Specific Proteases 14 in cancer: from canonical oncogenesis to TME modulation, therapeutic resistance, and non-canonical activities [PDF]
Journal of Translational MedicineBackground Ubiquitin-Specific Protease 14 (USP14) is a proteasome-associated deubiquitinase historically viewed as a pro-tumorigenic driver of the ubiquitin–proteasome system (UPS) by stabilizing oncoproteins.
RuoFeng Wang +9 more
doaj +2 more sources
Targeting ubiquitin-specific protease 14 reduces metastatic potential and metabolic activity in cervical cancer via direct modulation of monocarboxylate transporter-4 [PDF]
Journal of Translational MedicineBackground Cervical cancer (CC) remains a major health burden in low- and middle-income countries, where HPV vaccination coverage is suboptimal. Ubiquitin-specific peptidase 14 (USP14), a proteasome-associated deubiquitinase, has emerged as a potential ...
Ravi Chauhan +20 more
doaj +2 more sources
USP14 promotes epithelial-mesenchymal transition and functions as a multifaceted biomarker in lung adenocarcinoma [PDF]
Discover OncologyUbiquitin-specific protease 14 (USP14) is highly expressed in various tumors and functions as a critical regulator of proteasomal protein degradation.
Chenzhuo Wu +10 more
doaj +2 more sources
Cancer Medicine, 2018 Gastric cancer (GC) ranks the third leading cause of global cancer mortality. Despite recent progress in surgery combined with chemotherapy, the outcomes of GC patients have barely improved.
Liren Liu, Xishan Hao
exaly +2 more sources
Targeting USP14 enhances immunotherapy response by reprogramming tumor-associated macrophages in colon cancer [PDF]
iScienceSummary: Combining immunotherapy with other treatments improves survival in colorectal cancer (CRC), yet some patients remain unresponsive. Tumor-associated macrophages (TAMs) are a key immune cell population driving this immunotherapy resistance and ...
Dan Xiao, Jun Fang, Hui Jian, Yang Yu
doaj +2 more sources
The deubiquitination enzyme USP14 promotes the tumourigenesis of gastric cancer by enhancing c-MYC nuclear translocation through deubiquitination of KPNA2 [PDF]
Cell Death and DiseaseThe deubiquitinating enzyme USP14, which belongs to the ubiquitin-specific protease family, is highly expressed in various malignant tumors. The regulatory mechanisms in tumors are complex and diverse, encompassing a range of cellular processes such as ...
Jia Li +5 more
doaj +2 more sources
Ubiquitin-specific protease 14 inhibition promotes mitophagy and attenuates neural apoptosis after spinal cord injury [PDF]
Scientific ReportsSpinal cord injury (SCI) is a devastating condition characterized by severe neurological deficits and limited recovery, primarily due to the intricate cascade of secondary injury mechanisms.
Dingwei Wu +12 more
doaj +2 more sources