Results 11 to 20 of about 3,826 (176)

A kinetic model for USP14 regulated substrate degradation in 26S proteasome. [PDF]

PLoS Computational Biology
Despite high-resolution structural studies on the USP14-proteasome-substrate complexes, time-resolved cryo-electron microscopy (cryo-EM) results on USP14-regulated allostery of the 26S proteasome are still very limited and a quantitative understanding of
Di Wu, Qi Ouyang, Hongli Wang, Youdong Mao   +3 more
doaj   +5 more sources

Structural Dynamics Analysis of USP14 Activation by AKT-Mediated Phosphorylation [PDF]

Cells
Ubiquitin-specific protease 14 (USP14), one of the three major proteasome-associated deubiquitinating enzymes (DUBs), is known to be activated by the AKT-mediated phosphorylation at Ser432.
Raju Dash, Non-Nuoc Tran, Sung Bae Lee, Byung-Hoon Lee   +3 more
doaj   +5 more sources

USP14 inhibition enhances Parkin-independent mitophagy in iNeurons [PDF]

Pharmacological Research
Loss of proteostasis is well documented during physiological aging and depends on the progressive decline in the activity of two major degradative mechanisms: the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway.
Greta Bernardo, Miguel A. Prado, Anna Roshani Dashtmian, Mariavittoria Favaro, Sofia Mauri, Alice Borsetto, Elena Marchesan, Joao A. Paulo, Steve P. Gygi, Daniel J. Finley, Elena Ziviani   +10 more
doaj   +4 more sources

Function of Deubiquitinating Enzyme USP14 as Oncogene in Different Types of Cancer [PDF]

Cellular Physiology and Biochemistry, 2016
Background/Aims: Non-small cell lung cancer (NSCLC) tissues overexpress USP14, which promotes tumor cell proliferation and is associated with shorter overall survival time. Methods: The expression of USP14 was assayed in many types of cancers.
Ying Zhu, Chaoxiong Zhang, Changxin Gu, Qiang Li, Ning Wu   +4 more
doaj   +4 more sources

Dynamic Interaction of USP14 with the Chaperone HSC70 Mediates Crosstalk between the Proteasome, ER Signaling, and Autophagy [PDF]

iScience, 2020
Summary: USP14 is a deubiquitinating enzyme associated with the proteasome important for protein degradation. Here we show that upon proteasome inhibition or expression of the mutant W58A-USP14, association of USP14 with the 19S regulatory particle is ...
Vignesh Srinivasan, Celine Bruelle, Enzo Scifo, Dan Duc Pham, Rabah Soliymani, Maciej Lalowski, Dan Lindholm   +6 more
doaj   +2 more sources

USP14 promotes colorectal cancer progression by targeting JNK for stabilization

Cell Death and Disease, 2023
MAPK/JNK signaling is pivotal in carcinogenesis. However, ubiquitin-mediated homeostasis of JNK remains to be verified. Here, with results from RNA sequencing (RNA-seq) and luciferase reporter pathway identification, we show that USP14 orchestrates MAPK ...
Xue-Hua Du, Shao-Bo Ke, Xin-Yi Liang, Jie Gao, Xiao-Xiao Xie, Lin-Zhi Qi, Xue-Yi Liu, Guo-Yuan Xu, Xiao-Dong Zhang, Run-Lei Du, Shang-Ze Li   +10 more
doaj   +3 more sources

USP14: Structure, Function, and Target Inhibition [PDF]

Frontiers in Pharmacology, 2022
Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated with proteasomes and exerts a dual function in regulating protein degradation.
Feng Wang, Shuo Ning, Beiming Yu, Yanfeng Wang   +3 more
doaj   +3 more sources

Enhancement of proteasome activity by a small-molecule inhibitor of USP14 [PDF]

Nature, 2010
Proteasomes, the primary mediators of ubiquitin-protein conjugate degradation, are regulated through complex and poorly understood mechanisms. Here we show that USP14, a proteasome-associated deubiquitinating enzyme, can inhibit the degradation of ubiquitin-protein conjugates both in vitro and in cells.
Lee, Byung-Hoon, Lee, Min Jae, Park, Soyeon, Oh, Dong-Chan, Elsasser, Suzanne, Chen, Ping-Chung, Gartner, Carlos, Dimova, Nevena, Hanna, John, Gygi, Steven P., Wilson, Scott M., King, Randall W., Finley, Daniel   +12 more
openaire   +3 more sources

USP14 regulates cell cycle progression through deubiquitinating CDK1 in breast cancer

Acta Biochimica et Biophysica Sinica, 2022
Abnormal proliferation and cell cycle perturbation are the main hallmarks of breast cancer. Cyclin-dependent kinase 1 (CDK1) is one of the key kinases for cell transition from the G2 phase to M phase during the cell cycle progression.
Liu Yuhan, Xu Jing, Wang Yanan, Gan Mingxi, Hu Qifan, Wang Jianbin, Han Tianyu   +6 more
doaj   +4 more sources

Targeted therapy for cisplatin‐resistant lung cancer via aptamer‐guided nano‐zinc carriers containing USP14 siRNA

MedComm, 2023
Cisplatin (DDP) is a common therapeutic option for non‐small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important.
Xinmin Zhao, Xianghua Wu, Huijie Wang, Songtao Lai, Jialei Wang   +4 more
doaj   +2 more sources