Results 21 to 30 of about 4,153 (179)

USP14 is crucial for proteostasis regulation and α-synuclein degradation in human SH-SY5Y dopaminergic cells

Heliyon
Ubiquitin specific protease-14 (USP14) is critical for controlling proteostasis disturbed in human disorders, including Parkinson's disease (PD). Here we investigated USP14 in the regulation of α-synuclein (α-syn) degradation via the proteasome and ...
Vignesh Srinivasan, Rabah Soliymani, Larisa Ivanova, Ove Eriksson, Nina Peitsaro, Maciej Lalowski, Mati Karelson, Dan Lindholm   +7 more
doaj   +2 more sources

USP14 regulates cell cycle progression through deubiquitinating CDK1 in breast cancer

Acta Biochimica et Biophysica Sinica, 2022
Abnormal proliferation and cell cycle perturbation are the main hallmarks of breast cancer. Cyclin-dependent kinase 1 (CDK1) is one of the key kinases for cell transition from the G2 phase to M phase during the cell cycle progression.
Liu Yuhan, Xu Jing, Wang Yanan, Gan Mingxi, Hu Qifan, Wang Jianbin, Han Tianyu   +6 more
doaj   +2 more sources

USP14 as a Therapeutic Target Against Neurodegeneration: A Rat Brain Perspective [PDF]

Frontiers in Cell and Developmental Biology, 2020
In the recent past, many of the deubiquitinases (DUB) were found to modulate mitochondrial clearance or mitophagy and thus they are currently projected as therapeutic targets against neurodegeneration.
Chayan Banerjee, Chayan Banerjee, Moumita Roy, Moumita Roy, Moumita Roy, Rupsha Mondal, Rupsha Mondal, Joy Chakraborty, Joy Chakraborty   +8 more
doaj   +3 more sources

Usp14 is required for spermatogenesis and ubiquitin stress responses in Drosophila melanogaster [PDF]

Journal of Cell Science, 2020
Deubiquitylating (DUB) enzymes free covalently linked ubiquitin moieties from ubiquitin-ubiquitin and ubiquitin-protein conjugates, and thereby maintain the equilibrium between free and conjugated ubiquitin moieties and regulate ubiquitin-mediated ...
Deák Péter, Pál Margit, Kovács Levente, Nagy Ágota   +3 more
core   +6 more sources

Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide [PDF]

Journal of Experimental & Clinical Cancer Research, 2019
Background Androgen receptor (AR) is expressed in approximately 70% of breast tumors. Recent studies increasingly support AR as a potential therapeutic target of AR-positive breast cancer.
Xiaohong Xia, Chuyi Huang, Yuning Liao, Yuan Liu, Jinchan He, Zhiqiang Guo, Lili Jiang, Xuejun Wang, Jinbao Liu, Hongbiao Huang   +9 more
doaj   +3 more sources

Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (usp14). [PDF]

PLoS ONE, 2013
In this study, we identified and characterized an N-ethyl-N-nitrosourea (ENU) induced mutation in Usp14 (nmf375) that leads to adult-onset neurological disease.
Andrea G Marshall, Jennifer A Watson, Jada J Hallengren, Brandon J Walters, Lynn E Dobrunz, Ludwig Francillon, Julie A Wilson, Scott E Phillips, Scott M Wilson   +8 more
doaj   +2 more sources

USP14 exhibits high expression levels in hepatocellular carcinoma and plays a crucial role in promoting the growth of liver cancer cells through the HK2/AKT/P62 axis

BMC Cancer
Background Hepatocellular carcinoma (HCC) is a common malignant tumor with strong invasiveness and poor prognosis. Previous studies have demonstrated the significant role of USP14 in various solid tumors.
Nannan Zhang, Hui Zhang, Xiaobing Yang, Qiang Xue, Quhui Wang, Renan Chang, Lirong Zhu, Zhong Chen, Xiancheng Liu   +8 more
doaj   +2 more sources

miR-4782-3p Inhibited Non-Small Cell Lung Cancer growth via USP14

Cellular Physiology and Biochemistry, 2014
Background: Lung cancer is the leading cause of cancer-related mortality worldwide, with near 1.4 million deaths each year. NSCLC accounts for nearly 85% of all case of lung cancer. MiRNAs play important roles in regulation of gene expression at the post-
Ning Wu, Chaoxiong Zhang, Chong Bai, Yi Pang Han, Qiang Li   +4 more
doaj   +2 more sources

USP14 Inhibition Regulates Tumorigenesis by Inducing Autophagy in Lung Cancer In Vitro

International Journal of Molecular Sciences, 2019
The ubiquitin–proteasome system is an essential regulator of several cellular pathways involving oncogenes. Deubiquitination negatively regulates target proteins or substrates linked to both hereditary and sporadic forms of cancer.
Min Ji Kim, In-ho Jeong, Minseok Kwak, Jun-O Jin, Kyung Ho Han, Tae Hyeong Lee, Peter Chang-Whan Lee, Min-soo Park   +7 more
core   +3 more sources

Transient interdomain interactions in free USP14 shape its conformational ensemble

Protein Science
The deubiquitinase (DUB) ubiquitin-specific protease 14 (USP14) is a dual domain protein that plays a regulatory role in proteasomal degradation and has been identified as a promising therapeutic target.
Sjöstrand, Linda, D´arcy, Padraig,, Salomonsson, Johannes,, Wallner, Björn,, Wallner, Björn, Ahlner, Alexandra,, Sunnerhagen, Maria, D´arcy, Padraig, Salomonsson, Johannes, Ahlner, Alexandra, Sjöstrand, Linda,, Sunnerhagen, Maria,, D'Arcy, Pádraig   +12 more
core   +5 more sources