Results 41 to 50 of about 3,826 (176)

The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling [PDF]

Human Molecular Genetics, 2018
Primary cilia are hair-like organelles that play crucial roles in vertebrate development, organogenesis and when dysfunctional result in pleiotropic human genetic disorders called ciliopathies, characterized by overlapping phenotypes, such as renal and hepatic cysts, skeletal defects, retinal degeneration and central nervous system malformations ...
MASSA, FILOMENA, TAMMARO, ROBERTA, Prado, Miguel A, Marcella, Cesana, Byung-Hoon, Lee, Daniel, Finley, Brunella, Franco, MORLEO, MANUELA ANNA   +7 more
openaire   +5 more sources

USP14 deficiency inhibits neointima formation following vascular injury via degradation of Skp2 protein

Cell Death Discovery
Ubiquitin-proteasome system (UPS) is involved in vascular smooth muscle cell (VSMC) proliferation. Deubiquitinating enzymes (DUBs) have an essential role in the UPS-regulated stability of the substrate; however, the function of DUBs in intimal ...
Xiaohong Xia, Xiaolin Liu, Qiong Xu, Jielei Gu, Sisi Ling, Yajing Liu, Rongxue Li, Min Zou, Siqin Jiang, Zhiwei Gao, Canshan Chen, Shiming Liu, Ningning Liu   +12 more
doaj   +2 more sources

PSMC3 promotes RNAi by maintaining AGO2 stability through USP14

Cellular & Molecular Biology Letters, 2022
Abstract Background Argonaute 2 (AGO2), the only protein with catalytic activity in the human Argonaute family, is considered as a key component of RNA interference (RNAi) pathway. Here we performed a yeast two-hybrid screen using the human Argonaute 2 PIWI domain as bait to screen for new AGO2-interacting proteins and ...
Yan Jia, Jianing Zhao, Tao Yu, Xue Zhang, Xiaozhen Qi, Tongxin Hao, Zeyuan Jin, Xiaoqing Zhao   +7 more
openaire   +3 more sources

USP14 maintains HIF1-α stabilization via its deubiquitination activity in hepatocellular carcinoma

Cell Death and Disease, 2021
Hepatocellular carcinoma (HCC) is the most common visceral neoplasms with its heterogeneity and high rate of recurrence. HCC is characterized to be delayed diagnosis and the development of resistant disease.
Chi Lv, Shengli Wang, Lin Lin, Chunyu Wang, Kai Zeng, Yiming Meng, Ge Sun, Shan Wei, Yefu Liu, Yue Zhao   +9 more
doaj   +1 more source

Structure and mechanisms of the proteasome‐associated deubiquitinating enzyme USP14 [PDF]

The EMBO Journal, 2005
The ubiquitin-specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. Mammalian USP14 (Ubp6 in yeast) is unique among known UBP enzymes in that it is activated catalytically upon specific association with the 26S proteasome.
Min, Hu, Pingwei, Li, Ling, Song, Philip D, Jeffrey, Tatiana A, Chenova, Keith D, Wilkinson, Robert E, Cohen, Yigong, Shi   +7 more
openaire   +2 more sources

The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice [PDF]

, 2009
Ataxia represents a pathological coordination failure that often involves functional disturbances in cerebellar circuits. Purkinje cells (PCs) characterize the only output neurons of the cerebellar cortex and critically participate in regulating motor ...
Kneussel Matthias, Loebrich, S, Sven Loebrich, Hevers, Wulf, Michaela Schweizer, Eilers, Jens, Đikić, Ivan, Corinna Lappe-Siefke, Wilson, Scott M., Scott M Wilson, Waidmann Oliver B., Fehr Susanne, Schweizer, M, Kneussel, Matthias, Oliver B Waidmann, Fritschy Jean-Marc, Jean-Marc Fritschy, Wilson, S M, Schweizer Michaela, Jens Eilers, Eilers, J, Fritschy, Jean-Marc, Ivan Dikic, Fritschy, J M, Dikic, I, Schweizer, Michaela, Eilers Jens, Susanne Fehr, Waidmann, O B, Wilson Scott M., Fehr, Susanne, Matthias Kneussel, Fehr, S, Lappe-Siefke, Corinna, Waidmann, Oliver, Dikic Ivan, Loebrich Sven, Hevers Wulf, Lappe-Siefke, C, Hevers, W, Kneussel, M, Löbrich, Sven, Wulf Hevers, Lappe-Siefke Corinna   +43 more
core   +1 more source

Inhibiting USP14 ameliorates inflammatory responses in trophoblast cells by suppressing MAPK/NF‐κB signaling

Immunity, Inflammation and Disease, 2021
Background Preeclampsia can cause severe consequences for pregnant women and infants, and developing effective medicine or methods to prevent or treat patients with preeclampsia is urgently needed.
Yingzi Zhao, Fang Zong
doaj   +1 more source

USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites [PDF]

Nature, 2016
USP14 is a major regulator of the proteasome and one of three proteasome-associated deubiquitinating enzymes. Its effects on protein turnover are substrate-specific, for unknown reasons. We report that USP14 shows a marked preference for ubiquitin-cyclin B conjugates that carry more than one ubiquitin modification or chain.
Lee, Byung-Hoon, Lu, Ying, Prado, Miguel A., Shi, Yuan, Tian, Geng, Sun, Shuangwu, Elsasser, Suzanne, Gygi, Steven, King, Randall, Finley, Daniel   +9 more
openaire   +4 more sources

USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1

Cell Death and Disease, 2023
Nonalcoholic fatty liver disease (NAFLD) begins with excessive triglyceride accumulation in the liver, and overly severe hepatic steatosis progresses to nonalcoholic steatohepatitis (NASH), which is characterized by lipid peroxidation, inflammation, and ...
Dongqin Wei, Xin Tian, Longbo Zhu, Han Wang, Chao Sun   +4 more
doaj   +1 more source

USP14 promotes pyroptosis of human annulus fibrosus cells derived from patients with intervertebral disc degeneration through deubiquitination of NLRP3

Acta Biochimica et Biophysica Sinica, 2022
Intervertebral disc degeneration (IVDD) is a general disorder that results in low back pain and disability among many affected individuals. However, the current treatments for IVDD are limited to relieving the symptoms but do not solve the fundamental ...
Hai Bao, Mao Tianli, Du Chuanchao, Jia Fei, Liu Yu, Song Qingpeng, Pan Xiaoyu, Liu Xiaoguang, Zhu Bin   +8 more
doaj   +1 more source