Results 41 to 50 of about 4,153 (179)

PSMC3 promotes RNAi by maintaining AGO2 stability through USP14

Cellular & Molecular Biology Letters, 2022
Abstract Background Argonaute 2 (AGO2), the only protein with catalytic activity in the human Argonaute family, is considered as a key component of RNA interference (RNAi) pathway. Here we performed a yeast two-hybrid screen using the human Argonaute 2 PIWI domain as bait to screen for new AGO2-interacting proteins and ...
Yan Jia, Jianing Zhao, Tao Yu, Xue Zhang, Xiaozhen Qi, Tongxin Hao, Zeyuan Jin, Xiaoqing Zhao   +7 more
openaire   +3 more sources

Inhibiting USP14 ameliorates inflammatory responses in trophoblast cells by suppressing MAPK/NF‐κB signaling

Immunity, Inflammation and Disease, 2021
Background Preeclampsia can cause severe consequences for pregnant women and infants, and developing effective medicine or methods to prevent or treat patients with preeclampsia is urgently needed.
Yingzi Zhao, Fang Zong
doaj   +1 more source

USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1

Cell Death and Disease, 2023
Nonalcoholic fatty liver disease (NAFLD) begins with excessive triglyceride accumulation in the liver, and overly severe hepatic steatosis progresses to nonalcoholic steatohepatitis (NASH), which is characterized by lipid peroxidation, inflammation, and ...
Dongqin Wei, Xin Tian, Longbo Zhu, Han Wang, Chao Sun   +4 more
doaj   +1 more source

USP14-mediated stabilization of ACTN1 maintains mesenchymal characteristics in glioblastoma. [PDF]

Commun Biol
Glioblastoma (GBM) is a highly aggressive primary brain tumor with a dismal prognosis, particularly in its mesenchymal (MES) subtype, which correlates strongly with poor survival. Despite this, the mechanisms preserving MES identity remain poorly understood.
Qiu W, Shi X, Wei R, Song J, Ling Y, Hu Y, Song S, Chen Y, Yang H, Luo P, Chu L.   +10 more
europepmc   +3 more sources

USP14 de-ubiquitinates vimentin and miR-320a modulates USP14 and vimentin to contribute to malignancy in gastric cancer cells

Oncotarget, 2016
Vimentin plays important roles in the epithelial-to-mesenchymal transition (EMT). In this study, we found that vimentin was highly expressed in human gastric cancer (GC) tissues and cell lines and significantly promoted cell growth, migration and invasion.
Zhu, Ying, Zhang, Yan, Sui, Zhenhua, Zhang, Yi, Liu, Min, Tang, Hua   +5 more
openaire   +3 more sources

USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites [PDF]

Nature, 2016
USP14 is a major regulator of the proteasome and one of three proteasome-associated deubiquitinating enzymes. Its effects on protein turnover are substrate-specific, for unknown reasons. We report that USP14 shows a marked preference for ubiquitin-cyclin B conjugates that carry more than one ubiquitin modification or chain.
Lee, Byung-Hoon, Lu, Ying, Prado, Miguel A., Shi, Yuan, Tian, Geng, Sun, Shuangwu, Elsasser, Suzanne, Gygi, Steven, King, Randall, Finley, Daniel   +9 more
openaire   +4 more sources

USP14 promotes pyroptosis of human annulus fibrosus cells derived from patients with intervertebral disc degeneration through deubiquitination of NLRP3

Acta Biochimica et Biophysica Sinica, 2022
Intervertebral disc degeneration (IVDD) is a general disorder that results in low back pain and disability among many affected individuals. However, the current treatments for IVDD are limited to relieving the symptoms but do not solve the fundamental ...
Hai Bao, Mao Tianli, Du Chuanchao, Jia Fei, Liu Yu, Song Qingpeng, Pan Xiaoyu, Liu Xiaoguang, Zhu Bin   +8 more
doaj   +1 more source

Inhibition of USP14 suppresses the formation of foam cell by promoting CD36 degradation [PDF]

Journal of Cellular and Molecular Medicine, 2020
AbstractAtherosclerosis is regarded as a chronic progressive inflammatory disease and is a basic pathophysiological process in coronary artery disease which is life threatening in clinic. The formation of foam cell plays a key role in the pathogenesis of atherosclerosis. OxLDL is a significant factor in progression of coronary artery disease.
Fangcheng Zhang, Xiaohong Xia, Renjie Chai, Ruqin Xu, Qiong Xu, Mingke Liu, Xuke Chen, Bin Liu, Shiming Liu, Ningning Liu   +9 more
openaire   +2 more sources

Structural, Dynamic and Functional Studies of USP14 [Elektronisk resurs] : A Proteasome-Associated Deubiquitinating Enzyme Regulating Protein Degradation

, 2023
Ubiquitin-Specific Protease 14 (USP14) is a proteasome-associated deubiquitinating enzyme (DUB) involved in regulation of protein degradation and recycling of ubiquitin. USP14 consists of a Ubl domain connected to a USP domain via a flexible linker.
Bernadó, Pau,, Salomonsson, Johannes,, Sunnerhagen, Maria,, von Castelmur, Eleonore,, Ahlner, Alexandra,   +4 more
core   +2 more sources

Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.

PLoS ONE, 2019
USP14 is a cysteine protease deubiquitinase associated with the proteasome and plays important catalytic and allosteric roles in proteasomal degradation.
Jayashree Chadchankar, Victoria Korboukh, Leslie C Conway, Heike J Wobst, Chandler A Walker, Peter Doig, Steve J Jacobsen, Nicholas J Brandon, Stephen J Moss, Qi Wang   +9 more
doaj   +1 more source