Results 51 to 60 of about 4,153 (179)

Characterization And Functional Analysis Of USP14 [PDF]

, 2007
The ubiquitin proteasome system (UPS) is essential for regulated protein degrada-tion, a requirement for numerous neuronal process, including vesicle cycling, neuro-transmitter release, spine morphology, and synaptic plasticity.
Crimmins, Stephen Lewis
core   +1 more source

USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1 [PDF]

Genes & Development, 2016
The ubiquitin–proteasome system (UPS) and autophagy are two major intracellular degradative mechanisms that mediate the turnover of complementary repertoires of intracellular proteomes. Simultaneously activating both UPS and autophagy might provide a powerful strategy for the clearance of misfolded proteins.
Xu, Daichao, Shan, Bing, Sun, Huawang, Xiao, Juan, Zhu, Kezhou, Xie, Xingxing, Li, Xingyan, Liang, Wei, Lu, Xiaojuan, Qian, Lihui, Yuan, Junying   +10 more
openaire   +4 more sources

USP14 activation promotes tumor progression in hepatocellular carcinoma

Oncology Reports, 2015
To elucidate the molecular mechanisms underlying the pathogenesis and treatment of human primary hepatocellular carcinoma (HCC), it is important to explore novel HCC-associated genes. In the present study, we examined the expression of ubiquitin-specific peptidase 14 (USP14) in patients with HCC using quantitative PCR and immunohistochemical techniques.
Gang, Huang, Limei, Li, Weiping, Zhou
openaire   +3 more sources

Stimulating proteasomal degradation in human proteinopathies. [PDF]

FEBS J
The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Gierisch ME, Barchi E, Dantuma NP.
europepmc   +2 more sources

Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity [PDF]

Scientific Reports, 2015
AbstractThe ubiquitin-proteasome system (UPS) is the primary mechanism by which intracellular proteins, transcription factors and many proteotoxic proteins with aggregation-prone structures are degraded. The UPS is reportedly downregulated in various neurodegenerative disorders, with increased proteasome activity shown to be beneficial in many related ...
Lee, Jung Hoon, Shin, Seung Kyun, Jiang, Yanxialei, Choi, Won Hoon, Hong, Chaesun, Kim, Dong-Eun, Lee, Min Jae   +6 more
openaire   +3 more sources

Reactivity of USP14 toward ISG15VS is augmented by proteasomal association.

, 2013
USP14 and USP5 were generated by IVT. Their activity toward ISG15VS and UbVME was analyzed in the presence of increasing concentrations of purified human 26S proteasomes.
Daniël Blom (32523), Paul J. Galardy (32524), André Catic (32520), Hidde L. Ploegh (32525), Edda Fiebiger (32521), Gregory A. Korbel (32522)   +5 more
core   +1 more source

Exploring the Role of USP14 in CXCR4‐Mediated Neurodegeneration

The FASEB Journal, 2008
Alzheimer's disease (AD) is one of the most common dementias in today's society. While the cause is unknown, the accumulation of amyloid‐beta protein has been identified as the major factor promoting pathological changes in patients. Chemokine receptor expression, specifically CXCR4, has also been found to be upregulated in various regions in the ...
Marjelo Amia Mines, Yun Ding, J. Shawn Goodwin, Guo‐Huang Fan   +3 more
openaire   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

MFG-E8 stabilized by deubiquitinase USP14 suppresses cigarette smoke-induced ferroptosis in bronchial epithelial cells

Cell Death and Disease, 2023
Milk fat globule epidermal growth factor 8 (MFG-E8) participates in a range of cellular processes, including reducing apoptosis and oxidative stress. However, its protective activity against cigarette smoke-induced ferroptosis in the pathogenesis of the ...
Yanan Cui, Lijuan Luo, Zihang Zeng, Xiangming Liu, Tiao Li, Xue He, Yiming Ma, Weiwei Meng, Huihui Zeng, Yingjiao Long, Dandan Zong, Yan Chen   +11 more
doaj   +1 more source

Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice [PDF]

Journal of Neurochemistry, 2005
AbstractThe ataxia (axJ) mutation is a spontaneous recessive mutation that results in reduced expression of ubiquitin‐specific protease 14, Usp14. Mice homozygous for the axJ mutation are retarded for growth and exhibit several behavioral disorders, including a resting tremor and hindlimb paralysis. Although pathological defects appear to be limited to
Christopher, Anderson, Stephen, Crimmins, Julie A, Wilson, Greg A, Korbel, Hidde L, Ploegh, Scott M, Wilson   +5 more
openaire   +2 more sources