Results 51 to 60 of about 3,826 (176)

USP14 de-ubiquitinates vimentin and miR-320a modulates USP14 and vimentin to contribute to malignancy in gastric cancer cells

Oncotarget, 2016
Vimentin plays important roles in the epithelial-to-mesenchymal transition (EMT). In this study, we found that vimentin was highly expressed in human gastric cancer (GC) tissues and cell lines and significantly promoted cell growth, migration and invasion.
Zhu, Ying, Zhang, Yan, Sui, Zhenhua, Zhang, Yi, Liu, Min, Tang, Hua   +5 more
openaire   +3 more sources

USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1 [PDF]

Genes & Development, 2016
The ubiquitin–proteasome system (UPS) and autophagy are two major intracellular degradative mechanisms that mediate the turnover of complementary repertoires of intracellular proteomes. Simultaneously activating both UPS and autophagy might provide a powerful strategy for the clearance of misfolded proteins.
Xu, Daichao, Shan, Bing, Sun, Huawang, Xiao, Juan, Zhu, Kezhou, Xie, Xingxing, Li, Xingyan, Liang, Wei, Lu, Xiaojuan, Qian, Lihui, Yuan, Junying   +10 more
openaire   +4 more sources

USP14 activation promotes tumor progression in hepatocellular carcinoma

Oncology Reports, 2015
To elucidate the molecular mechanisms underlying the pathogenesis and treatment of human primary hepatocellular carcinoma (HCC), it is important to explore novel HCC-associated genes. In the present study, we examined the expression of ubiquitin-specific peptidase 14 (USP14) in patients with HCC using quantitative PCR and immunohistochemical techniques.
Gang, Huang, Limei, Li, Weiping, Zhou
openaire   +3 more sources

Facilitated Tau Degradation by USP14 Aptamers via Enhanced Proteasome Activity [PDF]

Scientific Reports, 2015
AbstractThe ubiquitin-proteasome system (UPS) is the primary mechanism by which intracellular proteins, transcription factors and many proteotoxic proteins with aggregation-prone structures are degraded. The UPS is reportedly downregulated in various neurodegenerative disorders, with increased proteasome activity shown to be beneficial in many related ...
Lee, Jung Hoon, Shin, Seung Kyun, Jiang, Yanxialei, Choi, Won Hoon, Hong, Chaesun, Kim, Dong-Eun, Lee, Min Jae   +6 more
openaire   +3 more sources

USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer

, 2022
Indoleamine 2,3 dioxygenase 1 (IDO1) is an attractive target for cancer immunotherapy. However, IDO1 inhibitors have shown disappointing therapeutic efficacy in clinical trials, mainly because of the activation of the aryl hydrocarbon receptor (AhR ...
Wu, Xianqiu, Mo, Shuang, Shi, Dongni, Liao, Wenting, Wang, Y. Alan, Jian, Yunting, Chen, Xin, Huang, Chengmei, Zhang, Chao, Zhang, Huizhong, Huang, Huilin, Liu, Guozhen, Zhang, Dongsheng, Li, Yue, Wang, Junye, Song, Libing, Li, Fengtian, Lin, Chuyong   +17 more
core   +1 more source

Structural, Dynamic and Functional Studies of USP14 : A Proteasome-Associated Deubiquitinating Enzyme Regulating Protein Degradation

, 2023
Ubiquitin-Specific Protease 14 (USP14) is a proteasome-associated deubiquitinating enzyme (DUB) involved in regulation of protein degradation and recycling of ubiquitin. USP14 consists of a Ubl domain connected to a USP domain via a flexible linker.
Salomonsson, Johannes
core   +2 more sources

MFG-E8 stabilized by deubiquitinase USP14 suppresses cigarette smoke-induced ferroptosis in bronchial epithelial cells

Cell Death and Disease, 2023
Milk fat globule epidermal growth factor 8 (MFG-E8) participates in a range of cellular processes, including reducing apoptosis and oxidative stress. However, its protective activity against cigarette smoke-induced ferroptosis in the pathogenesis of the ...
Yanan Cui, Lijuan Luo, Zihang Zeng, Xiangming Liu, Tiao Li, Xue He, Yiming Ma, Weiwei Meng, Huihui Zeng, Yingjiao Long, Dandan Zong, Yan Chen   +11 more
doaj   +1 more source

PSMD8 cooperates with USP14 to promote bladder cancer progression by inhibiting ferroptosis. [PDF]

iScience
The ubiquitin-proteasome system (UPS) is crucial for regulating protein stability and essential cellular functions, including cell survival and proliferation. Dysregulation of UPS components contributes directly to malignant tumor development. This study investigates the significance of the proteasome subunit PSMD8 in bladder cancer (BLCA) pathogenesis.
Wang X, Liu B, Tang Y, Wang J, Ren J, Hu R, Chen W, Fu D, Wu Y, Gui T, Wang J, Han P, Wei X, Li H, Bai Y.   +14 more
europepmc   +4 more sources

Exploring the Role of USP14 in CXCR4‐Mediated Neurodegeneration

The FASEB Journal, 2008
Alzheimer's disease (AD) is one of the most common dementias in today's society. While the cause is unknown, the accumulation of amyloid‐beta protein has been identified as the major factor promoting pathological changes in patients. Chemokine receptor expression, specifically CXCR4, has also been found to be upregulated in various regions in the ...
Marjelo Amia Mines, Yun Ding, J. Shawn Goodwin, Guo‐Huang Fan   +3 more
openaire   +1 more source

Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice [PDF]

Journal of Neurochemistry, 2005
AbstractThe ataxia (axJ) mutation is a spontaneous recessive mutation that results in reduced expression of ubiquitin‐specific protease 14, Usp14. Mice homozygous for the axJ mutation are retarded for growth and exhibit several behavioral disorders, including a resting tremor and hindlimb paralysis. Although pathological defects appear to be limited to
Christopher, Anderson, Stephen, Crimmins, Julie A, Wilson, Greg A, Korbel, Hidde L, Ploegh, Scott M, Wilson   +5 more
openaire   +2 more sources