Results 71 to 80 of about 3,826 (176)

A High‐Throughput Assay for Monitoring and Quantifying Amyloid‐β Accumulation and Clearance in Alzheimer's Disease Cell Models

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Alzheimer's disease (AD) is primarily caused by the aggregation and clearance of amyloid‐β (Aβ), but there are currently few tools available to track intracellular Aβ dynamics in living cells. Here, we develop a scalable fluorescence assay to identify and measure Aβ aggregation in living neuronal cells using the luminescent conjugated oligothiophene ...
Ajish Ariyath, Fraulein Denise Arigo, Anna Fyfe, W. M. A. D. Binosha Fernando, Ralph Martins, Prashant Bharadwaj   +5 more
wiley   +1 more source

Curcumin modulates β-catenin stabilization via targeting proteasomal deubiquitinating enzyme USP14☆

Pharmacological Research
Loss of β-catenin homeostasis is tightly associated with human malignancies, modulation of β-catenin stabilization could be an attractive strategy for cancer therapy. In the present study, we demonstrated that an ancient drug curcumin was associated with
Mengzhen Shen, Lizhe Chen, Jie Jiang, Ziye Wang, Qing Gong, Xue Zhang, Xisong Ke, Yi Qu   +7 more
doaj   +1 more source

Genetic background alters the severity and onset of neuromuscular disease caused by the loss of ubiquitin-specific protease 14 (usp14). [PDF]

PLoS ONE, 2013
In this study, we identified and characterized an N-ethyl-N-nitrosourea (ENU) induced mutation in Usp14 (nmf375) that leads to adult-onset neurological disease.
Andrea G Marshall, Jennifer A Watson, Jada J Hallengren, Brandon J Walters, Lynn E Dobrunz, Ludwig Francillon, Julie A Wilson, Scott E Phillips, Scott M Wilson   +8 more
doaj   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, Volume 13, Issue 24, 27 April 2026.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

Characterization And Functional Analysis Of USP14

, 2007
The ubiquitin proteasome system (UPS) is essential for regulated protein degrada-tion, a requirement for numerous neuronal process, including vesicle cycling, neuro-transmitter release, spine morphology, and synaptic plasticity.
Crimmins, Stephen Lewis
core   +1 more source

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, Volume 13, Issue 22, 17 April 2026.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

A High‐Throughput Screening Method for Identification of Inhibitors of the Deubiquitinating Enzyme USP14 [PDF]

Current Protocols in Chemical Biology, 2012
AbstractDeubiquitinating enzymes (DUBs) reverse the process of ubiquitination, and number nearly 100 in humans. In principle, DUBs represent promising drug targets, as several of the enzymes have been implicated in human diseases. The isopeptidase activity of DUBs can be selectively inhibited by targeting the catalytic site with drug‐like compounds ...
Byung-Hoon, Lee, Daniel, Finley, Randall W, King   +2 more
openaire   +2 more sources

Inibizione di USP14 incrementa la mitofagia Parkin-indipendente in iNeurons

, 2023
La perdita di proteostasi è ben documentata durante l'invecchiamento e dipende dal progressivo declino patologico dell'attività di due principali meccanismi degradativi: il sistema ubiquitina-proteasoma (UPS) e la via autofagico-lisosomiale.
BERNARDO, GRETA
core  

Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukaemia

Clinical and Translational Medicine, 2022
Background Chronic myeloid leukaemia (CML) is a haematological cancer featured by the presence of BCR‐ABL fusion protein with abnormal tyrosine kinase activation.
Liling Jiang, Qingyan He, Xin Chen, Aochu Liu, Wa Ding, Haichuan Zhang, Xinmei Chen, Huan Zhou, Yi Meng, Bingyuan Liu, Guanjie Peng, Chunyan Wang, Jinbao Liu, Xianping Shi   +13 more
doaj   +1 more source

Osteoarthritis: Epidemiology, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Osteoarthritis is a prevalent degenerative joint disease with a growing global burden. Its development involves complex interactions among epidemiological factors, pathological changes, molecular signaling, and epigenetic regulation. Understanding these mechanisms provides insights into disease progression and supports the development of therapeutic ...
Tianrui Chen, Wenlong Chen, Tianpeng Xu, Hong Wang, Yuheng Zhang, Li Wang, Sijie Zhu, Huaqiang Tao, Xing Yang   +8 more
wiley   +1 more source