Results 71 to 80 of about 4,153 (179)

Loss of the proteasomal deubiquitinase USP14 induces growth defects and a senescence phenotype in colorectal cancer cells

Scientific Reports
The proteasome-associated deubiquitinase USP14 is a potential drug target. Using an inducible USP14 knockout system in colon cancer cells, we found that USP14 depletion impedes cellular proliferation, induces cell cycle arrest, and leads to a senescence ...
Johannes Gubat, Linda Sjöstrand, Karthik Selvaraju, Kübra Telli, Pádraig D’Arcy   +4 more
doaj   +1 more source

USP25 stabilises GLI1 through K48‐linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
GLI1‐centred USP25‐GLI1 reciprocal regulation in OA‐relevant models. Hedgehog/GLI1 signalling transcriptionally reinforces USP25 expression, while USP25 deubiquitinates and stabilises GLI1. This reciprocal circuit is associated with inflammatory and cartilage‐catabolic changes in the tested models.
Qian Zhang, Yinyan Ye, Yijie Huang, Jun Li, Dongfeng Huang   +4 more
wiley   +1 more source

Ubiquitinated proteins accumulated in the cells expressing USP14 C114A.

, 2019
Ubiquitinated proteins accumulated in the cells expressing USP14 C114A.
Chandler A. Walker (2185126), Peter Doig (1550449), Victoria Korboukh (1330497), Nicholas J. Brandon (1701649), Jayashree Chadchankar (7840889), Leslie C. Conway (7023941), Steve J. Jacobsen (7840892), Stephen J. Moss (2794006), Qi Wang (22418), Heike J. Wobst (4028465)   +9 more
core   +1 more source

Biallelic USP14 variants cause a syndromic neurodevelopmental disorder

Genetics in Medicine
Imbalances in protein homeostasis affect human brain development, with the ubiquitin-proteasome system (UPS) and autophagy playing crucial roles in neurodevelopmental disorders (NDD). This study explores the impact of biallelic USP14 variants on neurodevelopment, focusing on its role as a key hub connecting UPS and autophagy.Here, we identified ...
Ebstein, Frédéric, Latypova, Xenia, Sharon Hung, Ka, Prado, Miguel, Lee, Byung-Hoon, Möller, Sophie, Wendlandt, Martin, Zieba, Barbara, Florenceau, Laëtitia, Vignard, Virginie, Poirier, Léa, Toutain, Bérénice, Moroni, Isabella, Dubucs, Charlotte, Chassaing, Nicolas, Horvath, Judit, Prokisch, Holger, Küry, Sébastien, Bézieau, Stéphane, Paulo, Joao, Finley, Daniel, Krüger, Elke, Ghezzi, Daniele, Isidor, Bertrand   +23 more
openaire   +5 more sources

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

Ubiquitinated Proteins Activate the Proteasomal ATPases by Binding to Usp14 or Uch37 Homologs [PDF]

Journal of Biological Chemistry, 2013
Degradation of ubiquitinated proteins by 26 S proteasomes requires ATP hydrolysis, but it is unclear how the proteasomal ATPases are regulated and how proteolysis, substrate deubiquitination, degradation, and ATP hydrolysis are coordinated. Polyubiquitinated proteins were shown to stimulate ATP hydrolysis by purified proteasomes, but only if the ...
Andreas, Peth, Nikolay, Kukushkin, Marc, Bossé, Alfred L, Goldberg   +3 more
openaire   +2 more sources

Osteomyelitis: Epidemiology, Classification, Pathophysiology, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
The immunosuppressive in OM Staphylococcus aureus employs multiple physical barriers to evade host immunity during skeletal infection, including biofilm formation on implant surfaces and necrotic bone tissues, invasion into the osteocyte lacuno‐canalicular network (OLCN), intracellular persistence within osteoblasts, osteoclasts, and osteocytes, and ...
Qingqiang Lei, Liangbin Lin, Peidong Pu, Jie Chen, Xianchao Su, Shubao Liu, Yanli Tong, Hui Yu   +7 more
wiley   +1 more source

Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang, Wenke Shen, Ping Yang, Dongxue Yang, Yuepeng Cao, Yuping Zhou   +5 more
wiley   +1 more source

METTL14‐Mediated N6‐Methyladenosine Exacerbates Acute Lung Injury via USP30/NCOA4‐Dependent Ferroptosis

MedComm, Volume 7, Issue 9, September 2026.
METTL14‐mediated N6‐methyladenosine aggravates ischemia/reperfusion‐induced acute lung injury by enhancing YTHDF1‐dependent USP30 expression. USP30 stabilizes NCOA4 through deubiquitination, thereby promoting ferritinophagy, iron accumulation, lipid peroxidation, and ferroptosis in lung epithelial cells.
Aming Sang, Qiongyue Zhang, Xianwu Zhou, Xiaohua Wang, Jin Wang, Xuemin Song, Li Li, Ling Li, Xinyi Li   +8 more
wiley   +1 more source

A High‐Throughput Screening Method for Identification of Inhibitors of the Deubiquitinating Enzyme USP14 [PDF]

Current Protocols in Chemical Biology, 2012
AbstractDeubiquitinating enzymes (DUBs) reverse the process of ubiquitination, and number nearly 100 in humans. In principle, DUBs represent promising drug targets, as several of the enzymes have been implicated in human diseases. The isopeptidase activity of DUBs can be selectively inhibited by targeting the catalytic site with drug‐like compounds ...
Byung-Hoon, Lee, Daniel, Finley, Randall W, King   +2 more
openaire   +2 more sources