Results 91 to 100 of about 3,826 (176)

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source

Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14

American Journal of Physiology-Cell Physiology, 2012
Homozygous ataxic mice ( ax J) express reduced levels of the deubiquitinating enzyme Usp14. They develop severe tremors by 2–3 wk of age, followed by hindlimb paralysis, and death by 6–8 wk. While changes in the ubiquitin proteasome system often result in the accumulation of ubiquitin protein aggregates and neuronal loss, these pathological markers ...
Bula J, Bhattacharyya, Scott M, Wilson, Hosung, Jung, Richard J, Miller   +3 more
openaire   +3 more sources

Drosophila ubiquitin-specific peptidase 14 stabilizes the PERIOD protein by regulating a ubiquitin ligase SLIMB

Communications Biology
The circadian clock orchestrates behavior and physiology through the oscillation of key clock proteins like PERIOD (PER). Here, we investigate the role of ubiquitin-specific peptidase 14 (USP14) in modulating PER stability and circadian rhythms in ...
So Who Kang, Jung-Eun Park, Soonhyuck Ok, Minhui Um, Hyeonjeong Son, Seunghee Byun, Nayoung Park, Su Jin Lee, Thị Xuân Thùy Trần, Gyeongmin Kim, Jeonghun Yeom, Kyunggon Kim, Eun Young Kim, Min-Ji Kang   +13 more
doaj   +1 more source

Mitochondria Pathway Signature Predicts Prognosis and Therapeutic Response and Identifies REXO2 as a Crucial Regulator in Breast Cancer

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Mitochondrial‐related pathways (MRPs) play a crucial role in cancer metabolism and progression; however, their prognostic value in breast cancer (BC) is still poorly understood. Methods We integrated multiomics data to investigate the landscape of MRPs in BC.
Zizhao Guo, Heng Cao, Chuqi Lei, Dongxu Ma, Jiang Wu, Zeyu Xing, Chenyu Zhao, Xiang Wang, Jianxiu Cui, Liu Jinhui   +9 more
wiley   +1 more source

Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma

Journal of Translational Medicine
Aberrant upregulation of the ubiquitin-specific protease 14 (USP14) has been found in some malignant tumors, including oral squamous cell carcinoma (OSCC).
Xingming Zhang, Lou Geng, Yi Tang, Yingying Wang, Youping Zhang, Chujiao Zhu, Hu Lei, Hanzhang Xu, Qi Zhu, Yingli Wu, Wenli Gu   +10 more
doaj   +1 more source

ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This study identifies ADP‐ribosylation factor‐like protein 3 (ARL3) as a novel chaperone that stabilizes estrogen receptor α (ERα) in breast cancer. ARL3 promotes tumor growth by recruiting USP10 to remove ubiquitin chains from ERα, preventing its degradation.
Han Li, Yang Liu, Zehao Cai, Kang Li, Shun Gao, Ailin Lan, Dan Shu, Kuan He, Xin Liu, Yang Peng, Shipeng Guo, Haochen Yu, Aishun Jin, Meiying Shen, Shengchun Liu   +14 more
wiley   +1 more source

Targeting Metabolic Reprogramming in Tumor: From Mechanisms to Precision Immunotherapies

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Cancer metabolic reprogramming is a key hallmark of tumorigenesis and antitumor immunity. It boosts tumor progression by enhancing cancer cell fitness in hostile microenvironments and facilitates immune evasion by evading natural and therapy‐driven antitumor immune responses.
Tong Zhang, Ping Gao, Linchong Sun
wiley   +1 more source

WP1130 inhibits the host deubiquitinase USP14 in murine macrophages.

, 2012
(A) WP1130 treatment inhibits the activity of multiple DUBs in murine macrophages. RAW cells were treated with DMSO (D, V+D) or 5 µM WP1130 (V+WP) for 30 minutes prior to infection.
Christiane E. Wobus (125963), Mohammad Ahmed (153607), Jeffrey W. Perry (153605), Kyeong-Ok Chang (5282), Hollis D. Showalter (153611), Nicholas J. Donato (153609)   +5 more
core   +1 more source

Ubiquitinated proteins accumulated in the cells expressing USP14 C114A.

, 2019
Ubiquitinated proteins accumulated in the cells expressing USP14 C114A.
Chandler A. Walker (2185126), Peter Doig (1550449), Victoria Korboukh (1330497), Nicholas J. Brandon (1701649), Jayashree Chadchankar (7840889), Leslie C. Conway (7023941), Steve J. Jacobsen (7840892), Stephen J. Moss (2794006), Qi Wang (22418), Heike J. Wobst (4028465)   +9 more
core   +1 more source

去泛素化酶USP14对炎症性肺部疾病模型中炎症反应因子的影响

Zhongguo shiyan zhenduanxue, 2021
目的研究去泛素化酶USP14在炎症性肺部疾病中对炎性细胞因子的调节作用及探索USP14的小分子抑制剂IU1对炎性反应细胞的炎性消退作用。方法 MLE12细胞过表达USP14或抑制USP14的表达后,通过LPS或TNF-α刺激细胞的方法产生炎症反应细胞模型,采用Western blot法检测IκB和USP14蛋白表达的变化情况,采用ELISA法检测炎性因子IL-6或KC及TNF-α的水平。结果与Vector相比,过表达USP14显著抑制了IκB蛋白水平表达 ...
王丹, 马奔卉, 李聪, 李超
doaj