Results 91 to 100 of about 4,153 (179)

The Deubiquitinating Enzyme USP14 Regulates Leukemic Chemotherapy Drugs-Induced Cell Apoptosis by Suppressing Ubiquitination of Aurora Kinase B

Cellular Physiology and Biochemistry, 2017
Background/Aims: Aurora kinase B is a mitotic checkpoint kinase that plays a pivotal role in mitosis by ensuring correct chromosome segregation and normal progression through mitosis.
Chunge Song, Ruojin Ma, Xiaoyu Yang, Sulei Pang   +3 more
doaj   +1 more source

USP43‐mediated deubiquitination of SLC7A11 protects against LPS‐induced acute lung injury by inhibiting ferroptosis

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Ubiquitin‐specific protease 43 (USP43) in up‐regulated during lipopolysaccharide (LPS)‐induced acute lung injury (ALI). USP43 interacts and inhibits the degradation of solute carrier family 7 member 11 (SLC7A11) by removing the K48‐linked ubiquitination of it, thereby suppressing ferroptosis.
Li Zhang, Jutong He, Ming Xu, Bamawa Mwengendi Joël, Guiomar Correia, Xuefeng Zhou, Xinyi Li, Hexiao Tang   +7 more
wiley   +1 more source

WP1130 inhibits the host deubiquitinase USP14 in murine macrophages.

, 2012
(A) WP1130 treatment inhibits the activity of multiple DUBs in murine macrophages. RAW cells were treated with DMSO (D, V+D) or 5 µM WP1130 (V+WP) for 30 minutes prior to infection.
Christiane E. Wobus (125963), Mohammad Ahmed (153607), Jeffrey W. Perry (153605), Kyeong-Ok Chang (5282), Hollis D. Showalter (153611), Nicholas J. Donato (153609)   +5 more
core   +1 more source

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, Volume 4, Issue 2, Page 91-107, June 2026.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source

Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma

Journal of Translational Medicine
Aberrant upregulation of the ubiquitin-specific protease 14 (USP14) has been found in some malignant tumors, including oral squamous cell carcinoma (OSCC).
Xingming Zhang, Lou Geng, Yi Tang, Yingying Wang, Youping Zhang, Chujiao Zhu, Hu Lei, Hanzhang Xu, Qi Zhu, Yingli Wu, Wenli Gu   +10 more
doaj   +1 more source

Gastric Cancer: Pathobiology and Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu, Miao Zhang, Yan Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meihang Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou   +16 more
wiley   +1 more source

The Role and Importance of Deubiquitinase Usp14 in MHC Class I Antigen Presentation

Major histocompatibility complex class I (MHC I) molecules are essential for antigen presentation and immune surveillance, and their expression is tightly regulated by multiple cellular pathways.
Badger, Cassie
core   +3 more sources

An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons [PDF]

, 2017
The ubiquitin-proteasome system (UPS) is responsible for most selective protein degradation in eukaryotes and regulates numerous cellular processes, including cell cycle control and protein quality control.
Suzanne Elsasser, Cheng, Chialin, Miguel A. Prado, Silva, M. Catarina, Haggarty, Stephen J, Gan, Li, Gahman, Timothy C, Seong, Changhyun, Sang-Won Min, Randall W. King, Changhyun Seong, Steven P. Gygi, Chialin Cheng, Silva, M Catarina, Elsasser, Suzanne, Hatle, Ketki M, Ketki M. Hatle, Min, Sang-Won, Finley, Daniel, Byung-Hoon Lee, Daniel Finley, M. Catarina Silva, Timothy C. Gahman, Haggarty, Stephen J., Jessica Robert, Gahman, Timothy C., Stephen J. Haggarty, King, Randall W., Monica Boselli, Lee, Byung-Hoon, Gygi, Steven P., Prado, Miguel A, Gygi, Steven P, King, Randall W, Lee, Byung Hoon, Li Gan, Hatle, Ketki M., Prado, Miguel A., Boselli, Monica, Robert, Jessica   +39 more
core   +1 more source

去泛素化酶USP14对炎症性肺部疾病模型中炎症反应因子的影响

Zhongguo shiyan zhenduanxue, 2021
目的研究去泛素化酶USP14在炎症性肺部疾病中对炎性细胞因子的调节作用及探索USP14的小分子抑制剂IU1对炎性反应细胞的炎性消退作用。方法 MLE12细胞过表达USP14或抑制USP14的表达后,通过LPS或TNF-α刺激细胞的方法产生炎症反应细胞模型,采用Western blot法检测IκB和USP14蛋白表达的变化情况,采用ELISA法检测炎性因子IL-6或KC及TNF-α的水平。结果与Vector相比,过表达USP14显著抑制了IκB蛋白水平表达 ...
王丹, 马奔卉, 李聪, 李超
doaj  

The Phenotypic Expression Of Usp14 Deficiency Is Dependent Upon Genetic Background [PDF]

, 2013
The ubiquitin proteasome system (UPS) plays a critical role in regulating a diversity of cellular processes that are essential to neuronal function, such as synaptic transmission, axon guidance, and neurite outgrowth.
Marshall, Andrea Gail
core