Results 81 to 90 of about 4,153 (179)

Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukaemia

Clinical and Translational Medicine, 2022
Background Chronic myeloid leukaemia (CML) is a haematological cancer featured by the presence of BCR‐ABL fusion protein with abnormal tyrosine kinase activation.
Liling Jiang, Qingyan He, Xin Chen, Aochu Liu, Wa Ding, Haichuan Zhang, Xinmei Chen, Huan Zhou, Yi Meng, Bingyuan Liu, Guanjie Peng, Chunyan Wang, Jinbao Liu, Xianping Shi   +13 more
doaj   +1 more source

PSMD8 cooperates with USP14 to promote bladder cancer progression by inhibiting ferroptosis. [PDF]

iScience
The ubiquitin-proteasome system (UPS) is crucial for regulating protein stability and essential cellular functions, including cell survival and proliferation. Dysregulation of UPS components contributes directly to malignant tumor development. This study investigates the significance of the proteasome subunit PSMD8 in bladder cancer (BLCA) pathogenesis.
Wang X, Liu B, Tang Y, Wang J, Ren J, Hu R, Chen W, Fu D, Wu Y, Gui T, Wang J, Han P, Wei X, Li H, Bai Y.   +14 more
europepmc   +4 more sources

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

USP14 Positively Modulates Head and Neck Squamous Carcinoma Tumorigenesis and Potentiates Heat Shock Pathway through HSF1 Stabilization

, 2023
The ubiquitin-proteasome system is a pivotal intracellular proteolysis process in posttranslational modification. It regulates multiple cellular processes.
Rui Zhao, Jie Wang, Feng Zeng, Zhanghong Xie, Mengqi Fan, Yuandi Xiang, Qingquan Hua, Shizhen Fang, Huanzhi Wan   +8 more
core   +1 more source

Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14

American Journal of Physiology-Cell Physiology, 2012
Homozygous ataxic mice ( ax J) express reduced levels of the deubiquitinating enzyme Usp14. They develop severe tremors by 2–3 wk of age, followed by hindlimb paralysis, and death by 6–8 wk. While changes in the ubiquitin proteasome system often result in the accumulation of ubiquitin protein aggregates and neuronal loss, these pathological markers ...
Bula J, Bhattacharyya, Scott M, Wilson, Hosung, Jung, Richard J, Miller   +3 more
openaire   +3 more sources

USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer

Molecular Medicine
Background Mitophagy, essential for cellular homeostasis, is involved in eliminating damaged mitochondria and is associated with cancer progression and chemoresistance.
Zhiyong Wang, Cheng Yu, Gengchen Xie, Kaixiong Tao, Zhijie Yin, Qing Lv   +5 more
doaj   +1 more source

USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites [PDF]

, 2017
USP14 is a major regulator of the proteasome and one of three proteasome-associated deubiquitinating enzymes1-9. Its effects on protein turnover are substrate specific, for unknown reasons.
Sun, Shuangwu, Lu, Ying, Elsasser, Suzanne, Gygi, Steven, Tian, Geng, King, Randall, Shi, Yuan, Finley, Daniel, Lee, Byung-Hoon, Prado, Miguel A.   +9 more
core   +1 more source

TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14 [PDF]

Nature Communications, 2018
AbstractThe proteasome is a complex protease critical for protein quality control and cell regulation, and its dysfunction is associated with cancer and other diseases. However, the mechanisms that control proteasome activity  in normal and malignant cells remain unclear. Here we report that TRIM11 enhances degradation of aberrant and normal regulatory
Liang Chen, Guixin Zhu, Eleanor M. Johns, Xiaolu Yang   +3 more
openaire   +3 more sources

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, Volume 13, Issue 48, 28 August 2026.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Drosophila ubiquitin-specific peptidase 14 stabilizes the PERIOD protein by regulating a ubiquitin ligase SLIMB

Communications Biology
The circadian clock orchestrates behavior and physiology through the oscillation of key clock proteins like PERIOD (PER). Here, we investigate the role of ubiquitin-specific peptidase 14 (USP14) in modulating PER stability and circadian rhythms in ...
So Who Kang, Jung-Eun Park, Soonhyuck Ok, Minhui Um, Hyeonjeong Son, Seunghee Byun, Nayoung Park, Su Jin Lee, Thị Xuân Thùy Trần, Gyeongmin Kim, Jeonghun Yeom, Kyunggon Kim, Eun Young Kim, Min-Ji Kang   +13 more
doaj   +1 more source